Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Martin Vokurka"'
Autor:
Tereza Brogyanyi, Zdeněk Kejík, Kateřina Veselá, Petr Dytrych, David Hoskovec, Michal Masařik, Petr Babula, Robert Kaplánek, Tomáš Přibyl, Jaroslav Zelenka, Tomáš Ruml, Martin Vokurka, Pavel Martásek, Milan Jakubek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117407- (2024)
Mitochondrial autophagy (mitophagy) is very important process for the maintenance of cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk and progression numerous serious diseases (e.g., oncological, neurod
Externí odkaz:
https://doaj.org/article/6d7479d30edb474cbe369d571a257d63
Autor:
Tereza Brogyányi, Robert Kaplánek, Zdeněk Kejík, Božena Hosnedlová, Veronika Antonyová, Nikita Abramenko, Kateřina Veselá, Pavel Martásek, Martin Vokurka, Des R. Richardson, Milan Jakubek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 155, Iss , Pp 113736- (2022)
Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron chelator, are promising therapeutic methods. In this st
Externí odkaz:
https://doaj.org/article/71ad92161a2345139eca8042ccbca7de
Autor:
Maryam Golshani, Ludmila Maffei Svobodová, Lubomír Štěpánek, Jan Zeman, Petra Nytrová, Helena Posová, Petra Petrásková, Olga Novotná, Michaela Nováková, Viktor Černý, Jiří Beneš, Libuše Kolářová, Martin Vokurka, Jiří Hrdý
Publikováno v:
Vaccines, Vol 10, Iss 12, p 2038 (2022)
Background: COVID-19 pandemic has led to a loss of human life in millions and devastating socio-economic consequences worldwide. So far, vaccination is the most effective long-term strategy to control and prevent severe COVID-19 disease. The aim of t
Externí odkaz:
https://doaj.org/article/6a6b6ff52f59481797d91f4a759fb8f1
Autor:
Betty Berezovsky, Jana Frýdlová, Iuliia Gurieva, Daniel W. Rogalsky, Martin Vokurka, Jan Krijt
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5899 (2022)
The purpose of the study was to investigate the expression of ferroportin protein following treatments that affect systemic hepcidin. Administration of erythropoietin to C57BL/6J mice decreased systemic hepcidin expression; it also increased heart fe
Externí odkaz:
https://doaj.org/article/aade612d0903448a9e8ddc48e6b0f5b0
Autor:
Jana Frydlova, Iveta Zednikova, Veronika Satrapova, Eva Pazourkova, Sarka Santorova, Zdenka Hruskova, Vladimir Tesar, Martin Vokurka, Petr Prikryl, Marie Korabecna
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4344 (2022)
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) represents an autoimmunity disease characterized by high mortality. For successful treatment, the detailed knowledge of its complex pathogenesis and the set of biomarkers for di
Externí odkaz:
https://doaj.org/article/3e8329ac1b2040bf9e95499fdc7484ae
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 964 (2022)
Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affe
Externí odkaz:
https://doaj.org/article/b84f20172f5847319cd1b25fdaf2eeaa
Autor:
Betty Berezovsky, Martin Báječný, Jana Frýdlová, Iuliia Gurieva, Daniel Wayne Rogalsky, Petr Přikryl, Vít Pospíšil, Emanuel Nečas, Martin Vokurka, Jan Krijt
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8209 (2021)
Erythropoietin (EPO) downregulates hepcidin expression to increase the availability of iron; the downregulation of hepcidin is mediated by erythroferrone (ERFE) secreted by erythroblasts. Erythroblasts also express transferrin receptor 2 (TFR2); howe
Externí odkaz:
https://doaj.org/article/572a3dd4dd8340ccafce2a1d128a5e36
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215028 (2019)
Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency. The purpose of the study was to examine the effect of these stimuli, either alone or in com
Externí odkaz:
https://doaj.org/article/41d652ffd7c84526973f3968bbdb36df
Autor:
Jan Krijt, Jana Frýdlová, Iuliia Gurieva, Petr Přikryl, Martin Báječný, Andrea U. Steinbicker, Martin Vokurka, Jaroslav Truksa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2650 (2021)
Matriptase-2, a serine protease expressed in hepatocytes, is a negative regulator of hepcidin expression. The purpose of the study was to investigate the interaction of matriptase-2 with hemojuvelin protein in vivo. Mice lacking the matriptase-2 prot
Externí odkaz:
https://doaj.org/article/0b7d040815df4f9b80b8dcf244771ec5
Autor:
Jana Frýdlová, Zuzana Rychtarčíková, Iuliia Gurieva, Martin Vokurka, Jaroslav Truksa, Jan Krijt
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186844 (2017)
Tmprss6-mutated mask mice display iron deficiency anemia and high expression of hepcidin. The aim of the study was to determine the effect of erythropoietin administration on proteins participating in the control of iron homeostasis in the liver and
Externí odkaz:
https://doaj.org/article/cdea54ec9fe14973bd0c5ad5b4418b04