Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Martin U, Schuhmann"'
Autor:
David Gorodezki, Jason Chiang, Angela N. Viaene, Philipp Sievers, Simone Schmid, Ursula Holzer, Frank Paulsen, Martin U. Schuhmann, Olaf Witt, Jens Schittenhelm, Martin Ebinger
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Within the past decade, incremental integration of molecular characteristics into the classification of central nervous system neoplasms increasingly facilitated precise diagnosis and advanced stratification, beyond potentially providing the
Externí odkaz:
https://doaj.org/article/9069839a96a349639041ffb7d13e3d51
Autor:
Azadeh Ebrahimi, Andreas Waha, Jens Schittenhelm, Georg Gohla, Martin U Schuhmann, Torsten Pietsch
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-6 (2024)
Abstract Methylation class “CNS tumor with BCOR/BCOR(L1)-fusion” was recently defined based on methylation profiling and tSNE analysis of a series of 21 neuroepithelial tumors with predominant presence of a BCOR fusion and/or characteristic CNV b
Externí odkaz:
https://doaj.org/article/92fcd0a00ff14cf69c66db510b0f1ecd
Autor:
Tibor Kelety, Ulrich‐Wilhelm Thomale, Daniela Kandels, Martin U. Schuhmann, Ahmed El Damaty, Jürgen Krauss, Michael C. Frühwald, Pablo Hernáiz Driever, Olaf Witt, Brigitte Bison, Monika Warmuth‐Metz, Torsten Pietsch, René Schmidt, Astrid K. Gnekow
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Introduction Neurosurgery is considered the mainstay of treatment for pediatric low‐grade glioma (LGG); the extent of resection determines subsequent stratification in current treatment protocols. Yet, surgical radicality must be balanced
Externí odkaz:
https://doaj.org/article/9835247168374d5b92afc12d21e76d00
Autor:
Daniel Feucht, Susanne R. Kerscher, Christer Ruff, Martin U. Schuhmann, Constantin Roder, Julian Zipfel
Publikováno v:
Cancer Medicine, Vol 12, Iss 24, Pp 22047-22055 (2023)
Abstract Introduction Glioblastoma (GBM) is a tumor with rapid growth and a possible relationship to elevated intracranial pressure (ICP). High ICP may not always be associated with clinical signs. A non‐invasive technique for assessment of ICP is
Externí odkaz:
https://doaj.org/article/e48690cc7e084e358a5641ae4661294c
Autor:
Hannes Becker, Antonio Vogelsberg, Daniel Feucht, Arne Estler, Deniz Tafrali, Jens Schittenhelm, Jakob Milla, Sylvia Kurz, Falko Fend, Marcos Tatagiba, Martin U. Schuhmann, Helene Hurth
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundNeoplastic lesions affecting peripheral nerves are rare in the general population and, most often, are benign peripheral nerve sheath tumors. However, a minority of lesions represent high-grade malignancies associated with a poor prognosis,
Externí odkaz:
https://doaj.org/article/4323a9a5e0574df08f29d088e2fe8b00
Publikováno v:
Cells, Vol 13, Iss 14, p 1215 (2024)
Pediatric low-grade gliomas (PLGGs) comprise a heterogeneous set of low-grade glial and glioneuronal tumors, collectively representing the most frequent CNS tumors of childhood and adolescence. Despite excellent overall survival rates, the chronic na
Externí odkaz:
https://doaj.org/article/162838ea0f524b0aadf96adc18bbc27c
Autor:
Romain Sigaud, Thomas K. Albert, Caroline Hess, Thomas Hielscher, Nadine Winkler, Daniela Kocher, Carolin Walter, Daniel Münter, Florian Selt, Diren Usta, Jonas Ecker, Angela Brentrup, Martin Hasselblatt, Christian Thomas, Julian Varghese, David Capper, Ulrich W. Thomale, Pablo Hernáiz Driever, Michèle Simon, Svea Horn, Nina Annika Herz, Arend Koch, Felix Sahm, Stefan Hamelmann, Augusto Faria-Andrade, Nada Jabado, Martin U. Schuhmann, Antoinette Y. N. Schouten-van Meeteren, Eelco Hoving, Tilman Brummer, Cornelis M. van Tilburg, Stefan M. Pfister, Olaf Witt, David T. W. Jones, Kornelius Kerl, Till Milde
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors (MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify patients likely to benefit from MAPKi therapy. Here, we identi
Externí odkaz:
https://doaj.org/article/87e41da8f9f6492d937e992bb05c9817
Autor:
Maximilian Iller, Felix Neunhoeffer, Lukas Heimann, Julian Zipfel, Martin U. Schuhmann, Simon Scherer, Markus Dietzel, Joerg Fuchs, Michael Hofbeck, Stefanie Hieber, Frank Fideler
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionInducing general anesthesia (GA) in children can considerably affect blood pressure, and the rate of severe critical events owing to this remains high. Cerebrovascular autoregulation (CAR) protects the brain against blood-flow-related inj
Externí odkaz:
https://doaj.org/article/66593347078143bab55306c4594656b3
Autor:
Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Martin Sill, Damian Stichel, Gnana Prakash Balasubramanian, Stephan Tippelt, Christof Kramm, Andrew M. Donson, Adam L. Green, Chris Jones, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Barbara C. Jones, Cornelis M. van Tilburg, Andrea Wittmann, Andrey Golanov, Marina Ryzhova, Jonas Ecker, Till Milde, Olaf Witt, Felix Sahm, David Reuss, David Sumerauer, Josef Zamecnik, Andrey Korshunov, Andreas von Deimling, Stefan M. Pfister, David T. W. Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landsca
Externí odkaz:
https://doaj.org/article/d294b00cf8014bf897f67d7d3d39f257
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-8 (2021)
Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) and late-onset idiopathic aqueductal stenosis (LIAS) are two forms of chronic adult hydrocephalus of different aetiology. We analysed overnight intracranial pressure (ICP) monitoring
Externí odkaz:
https://doaj.org/article/fd643e9ccdfd424c990ca8fc4d48c61b