Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Martin Tulp"'
Autor:
Jan H. van Maarseveen, Martin Tulp, Hans W. Scheeren, Pedro H. H. Hermkens, Chris G. Kruse, Gerard D. H. Dijkstra
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:131-136
The synthesis and the affinities for serotonin and tryptamine receptors of a series of N-oxy derivatives of tryptamine (6–8, 13–14) are reported. It was found that N-hydroxytryptamine (6) is a relatively selective ligand for the 5-HT1C receptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5e01109c274ccd964b866f217b58cf
https://doi.org/10.1002/recl.19931120210
https://doi.org/10.1002/recl.19931120210
Autor:
Berend Olivier, Jan Mos, Theo H. Hijzen, Arnoud H.J. Herremans, Ruud van Oorschot, Martin Tulp, Marlies L. Van Drimmelen
Publikováno v:
Pharmacology Biochemistry and Behavior. 64:421-427
Twelve pigeons were successfully (ED 50 = 2.4 mg/kg PO) trained to discriminate the 5-HT 1A/B receptor agonist eltoprazine (5.0 mg/kg PO) from its vehicle in a fixed-ratio (FR)30 two-key operant drug discrimination procedure. Tests for generalization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2557da0af786244723d68e610d099fb
https://doi.org/10.1016/s0091-3057(99)00073-8
https://doi.org/10.1016/s0091-3057(99)00073-8
Autor:
Hendrik Timmerman, Martin Tulp, Rob Leurs, Martin J.P. Adolfs, Obbe P. Zuiderveld, Wiro M.B.P. Menge
Publikováno v:
British Journal of Pharmacology. 116:2315-2321
1. In the present study we evaluated the receptor selectivity of the potent histamine H3 receptor antagonist, iodophenpropit (IPP) in comparison with the prototype antagonist, thioperamide. 2. IPP proved to be a potent competitive H3 receptor antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4c7c63226decf1487905989a57351f
https://doi.org/10.1111/j.1476-5381.1995.tb15071.x
https://doi.org/10.1111/j.1476-5381.1995.tb15071.x
Autor:
Jan A.M van der Heyden, Feenstra Roelof W, Long Stephen K, W. Kuipers, Janpeter de Moes, Martin Tulp, Chris G. Kruse, Henk Kling, Jos J. Hofma
Publikováno v:
ChemInform. 32
This paper describes the syntheses of several 1-aryl-4-(biarylmethylene)piperazines and the results of the determination of their affinity for D(2) and 5-HT(1A) receptors. A selection of these compounds was evaluated in vivo, resulting in the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2f14f423d737a95aa1483014a46931f
https://doi.org/10.1002/chin.200151159
https://doi.org/10.1002/chin.200151159
Autor:
Jan Mos, Jan A.M van der Heyden, Jef L. Slangen, Martin Tulp, Rian De Jonge, Guus Van Der Poel, Berend Olivier
Publikováno v:
Stress Medicine. 8:117-136
From ancient history to present times, mankind has sought for anxiolytics, and various medications have been found and consequently used, at present culminating in heavy benzodiazepine use. Side-effects such as dependence and tolerance have always in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bdbc51c7f79175c0bae0b28b4ff2e66
https://doi.org/10.1002/smi.2460080211
https://doi.org/10.1002/smi.2460080211
Publikováno v:
Drug discovery today. 11(23-24)
Do certain kinds of food contain pharmacologically active substances in concentrations that are high enough to have druglike effects when consumed? Are biologically active compounds in food indicative of therapeutic value? Is traditional drug develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71055f4cef86672afb74e74d56b1113
https://pubmed.ncbi.nlm.nih.gov/17129831
https://pubmed.ncbi.nlm.nih.gov/17129831
Autor:
Hiskias G. Keizer, Chris G. Kruse, and Arnoud H. J. Herremans, Janpeter de Moes, Herman H. van Stuivenberg, Hein K. A. C. Coolen, Arnold P. den Hartog, Martin Tulp, Rolf van Hes, Leonarda C. Niemann, Andrew C. McCreary, Rob H. Plekkenpol, Mayke B. Hesselink, Cees N. J. Stroomer, Bob Stork, Pieter Smid
Publikováno v:
Journal of medicinal chemistry. 48(22)
A series of novel bicyclic 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines was synthesized and evaluated on binding to dopamine D(2) receptors and serotonin reuptake sites. This class of compounds proved to be potent in vitro dopamine D(2) rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6dfd58fc02e458bbdfc217b38e9ce3
https://pubmed.ncbi.nlm.nih.gov/16250644
https://pubmed.ncbi.nlm.nih.gov/16250644
Autor:
Lars Bohlin, Martin Tulp
Publikováno v:
Bioorganicmedicinal chemistry. 13(17)
Do all natural compounds have a distinct biological activity, or are most of them merely biosynthetic debris? Many natural compounds have important biological functions, and certainly many more of the ample 200,000 currently known will ultimately pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e662270791a725f766b313975637095
https://pubmed.ncbi.nlm.nih.gov/16019216
https://pubmed.ncbi.nlm.nih.gov/16019216
Autor:
Lars Bohlin, Martin Tulp
Publikováno v:
Drug discovery today. 9(10)
‘There are more things between heaven and earth…’ Despite the progress of science during the past four centuries, Shakespeare's words did not lose their actuality. Knowledge about the etiology of diseases is still limited, and for many life-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e8de77c08074a95bb1cf7b60bb3a6e
https://pubmed.ncbi.nlm.nih.gov/15109950
https://pubmed.ncbi.nlm.nih.gov/15109950
Autor:
Martin Tulp, Lars Bohlin
Publikováno v:
Trends in pharmacological sciences. 23(5)
Prospecting the full biodiversity of nature to find leads for new drugs is not necessary. Because finding leads is aimed at identifying biological activity, structure is of secondary importance. Furthermore, although natural chemical diversity might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bac5c113f1b1dea7c7ce6f2b975f99
https://pubmed.ncbi.nlm.nih.gov/12008000
https://pubmed.ncbi.nlm.nih.gov/12008000