Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Martin Traebert"'
Autor:
Holger Sellner, Emilie Chapeau, Pascal Furet, Markus Voegtle, Bahaa Salem, Mickaël Le Douget, Vincent Bordas, Jean‐Marc Groell, Anne‐Laure Le Goff, Christine Rouzet, Thomas Wietlisbach, Thomas Zimmermann, Joseph McKenna, Cara E. Brocklehurst, Patrick Chène, Markus Wartmann, Clemens Scheufler, Joerg Kallen, Gareth Williams, Stephanie Harlfinger, Martin Traebert, Bérengère M. Dumotier, Tobias Schmelzle, Nicolas Soldermann
Publikováno v:
ChemMedChem.
Autor:
Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
Publikováno v:
Clinical Pharmacology and Therapeutics
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years
Autor:
Gary Gintant, Martin Traebert
Publikováno v:
Expert Opinion on Drug Discovery. 15:719-729
Human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) preparations are increasingly employed inHerein, the authors review the importance of understanding the functional characteristics of the evolving spectrum of simpler (2D) and more
Autor:
Andrea Ghetti, Paul E. Miller, Pierre Jordaan, Najah Abi-Gerges, Martin Traebert, Berengere Dumotier, Laszlo Urban
Publikováno v:
Toxicological Sciences
Substantial efforts have been recently committed to develop coronavirus disease-2019 (COVID-19) medications, and Hydroxychloroquine alone or in combination with Azithromycin has been promoted as a repurposed treatment. Although these drugs may increa
Autor:
Xiaolin Li, Martin Traebert, David McKenney, Dirksen E. Bussiere, Sylvia Ma, Katherine V. Thompson, Nirav Shah, Douglas C. Bauer, Wosenu Mergo, Duncan Armstrong, Richard Zang, Bhavin Kantariya, Jennifer A. Leeds, Bo Zhou, Ashish Patel, John Fuller, Tushar Patel, Alice Rico, William S. Sawyer, Colin Osborne, Heinz E. Moser, Mangesh Fulsunder, Yongjin Xu, Bret Benton, Swapnil Malekar, Shravanthi Madhavan, Jason Vo, Cheng Hu, Daniel Mutnick, Krunal Prajapati, Michael Wang, Katherine R Prosen, Louis E. Metzger, Carl J. Balibar, Darshit Patel, Jogitha Selvarajah, Sarah Williams, Shailesh Satasia, Peichao Lu, Bhavesh Dhumale, Kartik Shanghavi, Alexey Rivkin, Javier de Vicente, Wei Shu, Jonas Noeske, Anand Vala, Mark R. Sanderson, Cornelia Bellamacina, L. Mark Fisher, Lakhan Vala, Qin Yue, Charles R. Dean, Gianfranco De Pascale, Dennis A. Veselkov, Marcella Widya, Folkert Reck, Lauren M. Holder, Guillaume Lapointe, Colin K. Skepper, Daryl L. Richie, Anatoli Lvov
Publikováno v:
Skepper, C K, Armstrong, D, Balibar, C J, Bauer, D, Bellamacina, C, Benton, B M, Bussiere, D, De Pascale, G, De Vicente, J, Dean, C R, Dhumale, B, Fisher, L M, Fuller, J, Fulsunder, M, Holder, L M, Hu, C, Kantariya, B, Lapointe, G, Leeds, J A, Li, X, Lu, P, Lvov, A, Ma, S, Madhavan, S, Malekar, S, Mckenney, D, Mergo, W, Metzger, L, Moser, H E, Mutnick, D, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Rico, A, Sanderson, M R, Satasia, S, Sawyer, W S, Selvarajah, J, Shah, N, Shanghavi, K, Shu, W, Thompson, K V, Veselkov, D A, Williams, S L, Xu, Y, Yue, Q, Zang, R, Zho, B & Rivkin, A 2020, ' Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria ', Journal of Medicinal Chemistry, vol. 63, no. 14, pp. 7773-7816 . https://doi.org/10.1021/acs.jmedchem.0c00347
Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99afdf67109b37c858dc407505690414
https://kclpure.kcl.ac.uk/ws/files/133475695/Topoisomerase_Inhibitors_Addressing_Fluoroquinolone_SKEPPER_Acc16Jun2020E_ub7Jul2020_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/133475695/Topoisomerase_Inhibitors_Addressing_Fluoroquinolone_SKEPPER_Acc16Jun2020E_ub7Jul2020_GREEN_AAM.pdf
Autor:
Alan S. Bass, David Jones, Derek J. Leishman, Siddhartha Bhatt, Martin Traebert, Nils Dragsted, Jean-Pierre Valentin, Theodore J. Baird, Simon Authier, Ninette K. Andersen, Tomas Mow, Carrie Markgraf, Anders B. Lassen, Michael J. Curtis, Morten Laursen
Publikováno v:
Journal of pharmacological and toxicological methods. 105
In nonclinical toxicology the highest dose or exposure without test article-related adverse effects, known as the No Observed Adverse Effect Level (NOAEL), is a variable that may be determined. In safety pharmacology the vast majority of the endpoint
Autor:
Tomoharu Osada, Yama A. Abassi, Hong Shi, Jennifer B. Pierson, Sonja Stoelzle-Feix, Gary Gintant, Qianyu Dang, T.K. Feaster, Emily Pfeiffer Kaushik, Hua Rong Lu, Todd J. Herron, Li Pang, Ksenia Blinova, Godfrey L. Smith, Martin Traebert, Beibei Cai, Yasunari Kanda, Ralf Kettenhofen, Francis L. Burton, Katherine Czysz
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 117
Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the a
Autor:
J.-P. Valentin, William S. Redfern, Hugo M. Vargas, Michael K. Pugsley, Andrea Greiter-Wilke, Maxim Soloviev, Simon Authier, Tiffini Brabham, J.E. Koerner, Derek J. Leishman, Krystle Correll, Mike Engwall, Carrie Markgraf, Tomas Mow, Alfred Botchway, Martin Traebert
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:35-45
Safety Pharmacology studies are conducted to characterize the confidence by which biologically active new chemical entities (NCE) may be anticipated as safe. Non-clinical safety pharmacology studies aim to detect and characterize potentially undesira
Autor:
Klaus-Dieter Söhren, Frederik Flenner, Ingra Mannhardt, Marc D Lemoine, Alexandra Eder, Elisabeth Krämer, Konstantina Stathopoulou, Lucie Carrier, Maksymilian Prondzynski, Thomas Eschenhagen, Torsten Christ, Arne Hansen, Berengere Dumotier, Martin Traebert
Publikováno v:
Toxicological Sciences
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) may serve as a new assay for drug testing in a human context, but their validity particularly for the evaluation of inotropic drug effects remains unclear. In this blinded analysis
Autor:
Andy N. Mead, Pierre Jordaan, Kathryn Chapman, Will S. Redfern, Alessandra Giarola, Jean-Pierre Valentin, Samuel J. Jackson, Lorna Ewart, Philip Jarvis, Hugo M. Vargas, Martin Traebert, Hamid R. Amouzadeh
Publikováno v:
Regulatory Toxicology and Pharmacology. 80:348-357
Central Nervous System (CNS)-related safety concerns are major contributors to delays and failure during the development of new candidate drugs (CDs). CNS-related safety data on 141 small molecule CDs from five pharmaceutical companies were analyzed