Výsledky vyhledávání - "Martin Tomanik"

Development of an Enantioselective Synthesis of (−)-Euonyminol

Autor: Victor S. Batista, Zechun Wang, Martin Tomanik, Facheng Guo, Zhi Xu, Ke R. Yang, Seth B. Herzon

Publikováno v: The Journal of Organic Chemistry. 86:17011-17035

We detail the development of the first enantioselective synthetic route to euonyminol (1), the most heavily oxidized member of the dihydro-β-agarofuran sesquiterpenes and the nucleus of the macrocyclic alkaloids known as the cathedulins. Key steps i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37150f73d1cca78f48e841cb7a6927f1
https://doi.org/10.1021/acs.joc.1c02167

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β- and γ-C(sp3)-H Heteroarylation of Free Carboxylic Acids: A Modular Synthetic Platform for Diverse Quaternary Carbon Centers

Autor: Guangrong Meng, Liang Hu, Martin Tomanik, Jin‐Quan Yu

Publikováno v: Angewandte Chemie (International ed. in English).

Pd(II)-catalyzed C(sp3)-H activation of free carboxylic acids represents a significant advance from conventional cyclopalladation initiated reactions. However, developing a modular synthetic platform for diverse quaternary and tertiary carbon centers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d6d7c33682d5b2ba2f5ff49a7f626f
https://pubmed.ncbi.nlm.nih.gov/36307373

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Metric-Based Analysis of Convergence in Complex Molecule Synthesis

Autor: Ian Tingyung Hsu, Martin Tomanik, Seth B. Herzon

Publikováno v: Accounts of Chemical Research. 54:903-916

ConspectusConvergent syntheses are characterized by the coupling of two or more synthetic intermediates of similar complexity, often late in a pathway. At its limit, a fully convergent synthesis is achieved when commercial or otherwise readily availa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd187a5bcdf9842e5fe74967bf87a417
https://doi.org/10.1021/acs.accounts.0c00817

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Enantioselective Synthesis of Euonyminol

Autor: Seth B. Herzon, Zhi Xu, Martin Tomanik

Publikováno v: Journal of the American Chemical Society. 143:699-704

We describe an enantioselective total synthesis of the nonahydroxylated sesquiterpenoid euonyminol, the dihydro-β-agarofuran nucleus of the macrocyclic terpenoid alkaloids known as the cathedulins. Key features of the synthetic sequence include a hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078aeaf9a2ba9bb89484ea9e804e7d7f
https://doi.org/10.1021/jacs.0c12998

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Pd(II)-Catalyzed Synthesis of Bicyclo[3.2.1] Lactones

Autor: Martin, Tomanik, Shaoqun, Qian, Jin-Quan, Yu

Publikováno v: Journal of the American Chemical Society. 144(27)

Bicyclo[3.2.1] lactones are chemical scaffolds found in numerous bioactive natural products. Herein, we detail the development of a novel palladium(II)-catalyzed tandem intramolecular β-C(sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96f08a0b0bc8aaa04f5162af5d5e8f84
https://pubmed.ncbi.nlm.nih.gov/35763801

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Fragment Coupling Reactions in Total Synthesis That Form Carbon–Carbon Bonds via Carbanionic or Free Radical Intermediates

Autor: Seth B. Herzon, Ian Tingyung Hsu, Martin Tomanik

Publikováno v: Angewandte Chemie International Edition. 60:1116-1150

Fragment coupling reactions that form carbon-carbon bonds are valuable transformations in synthetic design. Advances in metal-catalyzed cross-coupling reactions in the early 2000s brought a high level of predictability and reliability to carbon-carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97eac683c9f2268857c0f34a869d13b
https://doi.org/10.1002/anie.201913645

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Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway

Autor: Bruno Commare, Antonio Togni, Daniel Abegg, Nan Qiu, Martin Tomanik, Dany Pechalrieu, Anton Shuster, Alexander Adibekian, Seth B. Herzon

Publikováno v: Journal of the American Chemical Society. 143(48)

Chemoproteomic profiling of cysteines has emerged as a powerful method for screening the proteome-wide targets of cysteine-reactive fragments, drugs, and natural products. Herein, we report the development and an in-depth evaluation of a tetrafluoroa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965b7ab2138da85b87590796a783d9af
https://pubmed.ncbi.nlm.nih.gov/34817176

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Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G

Autor: Antonio Togni, Bruno Commare, Nan Qiu, Seth B. Herzon, Alexander Adibekian, Dany Pechalrieu, Martin Tomanik, Daniel Abegg, Anton Shuster

Chemoproteomic profiling of cysteines has emerged as a powerful method for screening the proteome-wide targets of cysteine-reactive fragments, drugs and natural products. Herein, we report the development and an in-depth evaluation of a tetrafluoroal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3189a32b5df2e0495e406f835a1f9e1f
https://doi.org/10.33774/chemrxiv-2021-2001z

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