Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Martin Termathe"'
Autor:
Johannes Brägelmann, Marcel A. Dammert, Felix Dietlein, Johannes M. Heuckmann, Axel Choidas, Stefanie Böhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A. French, Martin Peifer, H. Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C. Heukamp, Reinhard Büttner, Daniel Rauh, Bert M. Klebl, Roman K. Thomas, Martin L. Sos
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcin
Externí odkaz:
https://doaj.org/article/65260813004b4d5e8d198b9f59d2baa6
Autor:
Martin Termathe, Sebastian A. Leidel
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 139 (2021)
Urm1 (ubiquitin related modifier 1) is a molecular fossil in the class of ubiquitin-like proteins (UBLs). It encompasses characteristics of classical UBLs, such as ubiquitin or SUMO (small ubiquitin-related modifier), but also of bacterial sulfur-car
Externí odkaz:
https://doaj.org/article/79fb53bacc2d4751ab0245d139b8e9bf
Autor:
Matthäus Getlik, Jeffrey R Simard, Martin Termathe, Christian Grütter, Matthias Rabiller, Willem A L van Otterlo, Daniel Rauh
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39713 (2012)
The vast majority of small molecules known to modulate kinase activity, target the highly conserved ATP-pocket. Consequently, such ligands are often less specific and in case of inhibitors, this leads to the inhibition of multiple kinases. Thus, sele
Externí odkaz:
https://doaj.org/article/87ccca3039fb4ca1a25928d702a9a1d7
Autor:
Urszula Jankowska, Sebastian A. Leidel, Mikołaj Sokołowski, Martin Termathe, Przemyslaw Grudnik, Sebastian Glatt, Rościsław Krutyhołowa, Marta Pabis, Keerthiraju Ethiraju Ravichandran, Sandra D. Kienast
Publikováno v:
The EMBO Journal
Pabis, Marta; Termathe, Martin; Ravichandran, Keerthiraju E; Kienast, Sandra D.; Krutyhołowa, Rościsław; Sokołowski, Mikołaj; Jankowska, Urszula; Grudnik, Przemysław; Leidel, Sebastian A.; Glatt, Sebastian (2020). Molecular basis for the bifunctional Uba4–Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation. The EMBO journal, 39(19) EMBO Press 10.15252/embj.2020105087
Pabis, Marta; Termathe, Martin; Ravichandran, Keerthiraju E; Kienast, Sandra D.; Krutyhołowa, Rościsław; Sokołowski, Mikołaj; Jankowska, Urszula; Grudnik, Przemysław; Leidel, Sebastian A.; Glatt, Sebastian (2020). Molecular basis for the bifunctional Uba4–Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation. The EMBO journal, 39(19) EMBO Press 10.15252/embj.2020105087
The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin‐related modifier 1 (Urm1) pathway is responsible for the synthesis of 2‐thiolated wobble uridine (U34
Autor:
Martin Termathe, Sebastian A. Leidel
Publikováno v:
Nucleic Acids Research
Eukaryotic ubiquitin-like proteins (UBLs) have evolved from prokaryotic sulfur-carrier proteins (SCPs). Ubiquitin related modifier 1 (Urm1) shares biochemical and structural features of UBLs and SCPs and is essential for 2-thiolation of cytoplasmic t
Autor:
Felix Dietlein, Roman K. Thomas, Martin Peifer, Daniel Rauh, Zoltán Varga, Johannes M. Heuckmann, Axel Choidas, Johannes Brägelmann, Jan Eickhoff, Carina Lorenz, Hyatt Balke-Want, György Kéri, Zhizhou Fang, Stefanie Böhm, Zoltán Greff, Muhammad Sallouh, Martin Termathe, Reinhard Büttner, Debjit Basu, Christopher A. French, Uwe Koch, Frauke Leenders, André Richters, Martin L. Sos, Verena Tischler, Bert Klebl, Sascha Ansén, Peter Habenberger, Laszlo Orfi, Matthäus Getlik, Sandra Ortiz-Cuaran, Marcel A. Dammert, Lukas C. Heukamp, H. Christian Reinhardt
Publikováno v:
Cell Reports
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Summary Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midlin
Autor:
Kateryna Shostak, Sebastian A. Leidel, Alain Chariot, Alexandra Florin, Reinhard Büttner, Laurent Nguyen, Iva Klevernic, Lars Tharun, Hadrien Desmecht, Pierre Close, Francesca Rapino, Christophe Desmet, Zhaoli Zhou, Martin Termathe, Sylvain Delaunay, Lukas C. Heukamp, Anne E. Willis
Publikováno v:
The Journal of Experimental Medicine
Delaunay et al. reveal the role of U34 tRNA-modifying enzymes in the regulation of specific mRNA translation to support cell invasion and metastasis.
Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cance
Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cance
Autor:
Roland Klassen, Barbara De Coninck, Sebastian A. Leidel, Geert De Jaeger, Bruno P. A. Cammue, Alain Goossens, Takayuki Tohge, Martin Termathe, Sabine Le Gall, Mieke Van Lijsebettens, Raffael Schaffrath, Kris Gevaert, Alisdair R. Fernie, Rebecca De Clercq, Andrés Ritter, Laurens Pauwels, Sabrina Iñigo, Astrid Nagels Durand, Jelle Van Leene
Publikováno v:
Plant Physiology
PLANT PHYSIOLOGY
PLANT PHYSIOLOGY
Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions. Arabidopsis (Arabidopsis thaliana) has a sole class II c
Autor:
Martin Termathe, René P. Zahedi, Johannes M. Heuckmann, Matthäus Getlik, Daniel Rauh, Stefano Tomassi, Franziska Hoffgaard, Niklas Schaumann, Julian Engel, Verena Tinnefeld, Carsten Schultz-Fademrecht, Jasmin Krüll, Christian Grütter, Martin L. Sos, Simone Eppmann, Stefan M. Kast, Patrick Kibies, Marina Keul, Sascha Menninger, Svenja C. Mayer-Wrangowski, Sandra Ortiz-Cuaran, Roman K. Thomas, Jonas Lategahn, André Richters, Niklas Uhlenbrock, Christian Becker, Jochen Heil
Publikováno v:
Journal of medicinal chemistry. 58(17)
Receptor tyrosine kinases represent one of the prime targets in cancer therapy, as the dysregulation of these elementary transducers of extracellular signals, like the epidermal growth factor receptor (EGFR), contributes to the onset of cancer, such