Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Martin Tepel"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The forkhead box P3 (FOXP3) transcript is essential for tolerance of alloantigens. Here, we describe the expression of FOXP3 mRNA variants in healthy females and males, and in kidney transplant recipients (KTR). We measured FOXP3 in peripher
Externí odkaz:
https://doaj.org/article/f74d64f00e884f41a8d10ad046265dfe
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1124 (2024)
The objective of the present study was to compare principal cell-specific aquaporin-2 (AQP2) abundances in urinary extracellular vesicles (uEVs) on the first postoperative day in deceased-donor kidney transplant recipients without and with acute kidn
Externí odkaz:
https://doaj.org/article/36ec00dbf8494e0d835c2800ec7f1bad
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundProgressive decline of allograft function leads to premature graft loss. Forkhead box P3 (FOXP3), a characteristic gene of T-regulatory cells, is known to be essential for auto-antigen tolerance. We assessed the hypothesis that low FOXP3 mR
Externí odkaz:
https://doaj.org/article/6873d5e1c1ce4074b1c8568343a97524
Autor:
Firas F. Alkaff, MD, Daan Kremer, MD, Olivier Thaunat, MD, PhD, Stefan P. Berger, MD, PhD, Jacob van den Born, PhD, Federica Genovese, PhD, Morten A. Karsdal, PhD, Stephan J. L. Bakker, MD, PhD, Daniel G. K. Rasmussen, PhD, Martin Tepel, MD
Publikováno v:
Transplantation Direct, Vol 10, Iss 3, p e1591 (2024)
Background. Kidney fibrosis is a suggested cause of kidney failure and premature mortality. Because collagen type VI is closely linked to kidney fibrosis, we aimed to evaluate whether urinary endotrophin, a collagen type VI fragment, is associated wi
Externí odkaz:
https://doaj.org/article/c8aa90a7f031435095eeb219f8b3ce33
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1258 (2024)
Peripheral blood mononuclear cells contain secretory granules with Perforin and Granzyme B for defense against pathogens. The objective of the present study was to compare the effects of immunosuppressive induction therapies on Perforin and Granzyme
Externí odkaz:
https://doaj.org/article/6efcbfb34cad4dde8bc34e0421a2763d
Autor:
Emma S. Speedtsberg, Martin Tepel
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Background and aimsOutcome trials using sodium glucose cotransporter type 2 inhibitors have consistently shown their potential to preserve kidney function in diabetic and nondiabetic patients. Several mechanisms have been introduced which may explain
Externí odkaz:
https://doaj.org/article/32ba1bc7c0624eac89059bfb0cce62c8
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Forkhead Box P3 (FOXP3) is crucial for the development and suppressive function of human regulatory T cells (Tregs). There are two predominant FOXP3 splicing isoforms in healthy humans, the full-length isoform and the isoform lacking exon 2, with dif
Externí odkaz:
https://doaj.org/article/2a23b7a6c11344ef87d5330f82ce54b6
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmunosuppressive treatment of kidney transplant recipients is mainly aimed at pro-inflammatory T effector cells, yet they also target the immunosuppressive T regulatory cells. Here, we test the hypothesis that low levels of the master gene
Externí odkaz:
https://doaj.org/article/119986c58a744d219e3f46d6bfa71919
Autor:
Martin Tepel, Firas F. Alkaff, Daan Kremer, Stephan J. L. Bakker, Olivier Thaunat, Subagini Nagarajah, Qais Saleh, Stefan P. Berger, Jacob van den Born, Nicoline V. Krogstrup, Marie B. Nielsen, Rikke Nørregaard, Bente Jespersen, Nadja Sparding, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Delayed graft function after kidney transplantation is common and increases morbidity and health care costs. There is evidence that endotrophin, a specific fragment of pro-collagen type VI, promotes the inflammatory response in kidney diseas
Externí odkaz:
https://doaj.org/article/dc8376e1ebb242f882d7aef601a70e13
Autor:
Martin Tepel, Subagini Nagarajah, Qais Saleh, Olivier Thaunat, Stephan J. L. Bakker, Jacob van den Born, Morten A. Karsdal, Federica Genovese, Daniel G. K. Rasmussen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Better characterization of the potential kidney transplant recipient using novel biomarkers, for example, pretransplant plasma endotrophin, will lead to improved outcome after transplantation. This mini-review will focus on current knowledge about pr
Externí odkaz:
https://doaj.org/article/5a0b8377495340fd9ceeb29ab05d077f