Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Martin Stahlhut"'
Autor:
Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dünstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Glucocorticoids (GCs) are commonly used topical treatments for skin diseases but are associated with both local and systemic side effects. In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical
Externí odkaz:
https://doaj.org/article/cfd4a2be093d473793d9d6101bfebe75
Autor:
Mark D. Andrews, Kevin N. Dack, Marcel J. de Groot, Maja Lambert, Carl J. Sennbro, Mogens Larsen, Martin Stahlhut
Publikováno v:
Journal of Medicinal Chemistry. 65:8828-8842
Interleukin 17A (IL-17A) is an interleukin cytokine whose dysregulation is implicated in autoimmune disorders such as psoriasis, and monoclonal antibodies against the IL-17A pathway are now well-established and very effective treatments. This article
Autor:
Karen Skriver, Signe A. Sjørup, Annette E. Langkilde, Evanthia Balouka, Caspar S. Christensen, Kathrine Carbel, Jens N. V. Decker, David N. Essenbæk, Justus F. Gräf, Camilla H. Jessen, Peter Kristensen, Christoffer Merrild, Tobias S. Mortensen, Isabella F. Nalepa, Bjørn W. Nordsteen, Sophie K. Svoren, Matthijs van Hall, Jan Weicher, Malene L. Wind, Danping Zhang, Daniel Saar, Helle Blæsild, Martin Stahlhut, Kim V. Andersen, Robert Dagil, Bente Vestergaard, Marie L. Ryberg, Birthe B. Kragelund
Publikováno v:
Skriver, K, Sjørup, S A, Langkilde, A E, Balouka, E, Christensen, C S, Carbel, K, Decker, J N V, Essenbæk, D N, Gräf, J F, Jessen, C H, Kristensen, P, Merrild, C, Mortensen, T S, Nalepa, I F, Nordsteen, B W, Svoren, S K, van Hall, M, Weicher, J, Wind, M L, Zhang, D, Saar, D, Blæsild, H, Stahlhut, M, Andersen, K V, Dagil, R, Vestergaard, B, Ryberg, M L & Kragelund, B B 2023, ' Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching ', The Biophysicist, vol. 4, no. 2, pp. 1-7 . https://doi.org/10.35459/tbp.2022.000221
Integrating research and teaching in a meaningful manner is a challenge. With the growing number of students in universities and the rapid advances and innovations across many fields and technologies, the one-on-one mentor relationship seems utopia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669a9ed5a40b98fd664ed05f62fe9599
https://curis.ku.dk/ws/files/340402867/Intrinsically_Disordered_Proteins_as_an.pdf
https://curis.ku.dk/ws/files/340402867/Intrinsically_Disordered_Proteins_as_an.pdf
Autor:
Ivaylo Jivkov Elenkov, Simon Feldbaek Nielsen, Kristina Butković, Sanja Koštrun, Dijana Pesic, Dack Kevin Neil, Tine Skak-Nielsen, Dinko Žiher, Martin Stahlhut, Adriana Petrinić Grba, Vlatka Bencetić Mihaljević, Ana Čikoš, Samra Kapić, Andrea Fajdetić, Renata Rupčić, Gordon Saxty, Maja Lambert, Jasna Padovan, Ivana Ozimec Landek, Karmen Brajša, Dubravko Jelić, Haakan Bladh, Ana Grgičević
Publikováno v:
Journal of Medicinal Chemistry. 64:8354-8383
Interleukin 17 (IL-17) cytokines promote inflammatory pathophysiology in many autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Such broad involvement of IL-17 in various autoimmune di
Autor:
Anna Ollerstam, Krister Henriksson, Patrick Stephen Johnson, Martin A. Carnerup, Martin Stahlhut, Dack Kevin Neil, Stefan Eirefelt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127402
Steroidal glucocorticoids (GR agonists) have been widely used for the topical treatment of skin disorders, including atopic dermatitis. They are a very effective therapy, but they are associated with both unwanted local effects in the skin (skin thin
Publikováno v:
REPRODUCTION. 150:11-20
Phosphodiesterases (PDEs) are important regulators of the intracellular cAMP concentration, which is a central second messenger that affects a multitude of intracellular functions. In the ovaries, cAMP exerts diverse functions, including regulation o
Autor:
Malene Bertelsen, Kristoffer Månsson, Thomas Högberg, Anke Soor, Morten Dahl Sørensen, Gunnar Grue-Sørensen, Karen Margrethe Engell, Martin Stahlhut, Per Vedsø, Xifu Liang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:54-60
Ingenol 3-benzoates were investigated with respect to chemical stability, pro-inflammatory effects, cell death induction and PKCδ activation. A correlation between structure, chemical stability and biological activity was found and compared to ingen
Autor:
Karen Margrethe Engell, Kristoffer Månsson, Martin Stahlhut, Malene Bertelsen, Xifu Liang, Gunnar Grue-Sørensen, Thomas Högberg, Anke Soor, Per Vedsø
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5624-5629
Ingenol mebutate is the active ingredient in Picato® a new drug for the treatment of actinic keratosis. A number of derivatives related to ingenol mebutate were prepared by chemical synthesis from ingenol with the purpose of investigating the SAR an
Autor:
Martin Stahlhut, Morten Schak Nielsen, Jørgen Petersen, Anne-Louise Kjølbye, James K. Hennan, Ketil Haugan, Niels-Henrik Holstein-Rathlou, Lene Nygaard Axelsen
Publikováno v:
Journal of Membrane Biology. 216:23-35
Much of our current knowledge about the physiological and pathophysiological role of gap junctions is based on experiments where coupling has been reduced by either chemical agents or genetic modification. This has brought evidence that gap junctions