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pro vyhledávání: '"Martin Spoden"'
Publikováno v:
International Journal of Peptide and Protein Research. 46:221-227
In order to study the role of the amino acid in position B25 and its environment in shortened insulins, a series of analogues was prepared with the following modifications: 1, Stepwise shortening of the B-chain including replacements of TyrB26 and Th
Autor:
Dietrich Brandenburg, Hans-Gregor Gattner, Cornelia Diaconescu, Monika Casaretto, Helmut Zahn, Martin Spoden, Axel Wollmer
Publikováno v:
Biological Chemistry Hoppe-Seyler. 368:709-716
After it has been shown that removal of residues B26-B30 leaves insulin with full biological activity, provided the new C-terminus is amidated (Fischer et al. (1985) Biol. Chem. Hoppe-Seyler 366, 521-525), it is demonstrated here that it does not eve