Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Martin Scobie"'
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108907- (2024)
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoa
Externí odkaz:
https://doaj.org/article/62a8b016c8c04843b50875f18c4706f6
Autor:
Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov Wallner, Martin Scobie, Andreas Schmidt, Annika Jenmalm-Jensen, Ulrika Warpman Berglund, Thomas Helleday
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 11642-11656 (2019)
Externí odkaz:
https://doaj.org/article/3f7274d022194d0ca6d4993a4d0905a5
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulatio
Externí odkaz:
https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4
Autor:
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleday
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3407-3416 (2016)
Externí odkaz:
https://doaj.org/article/358a7d08f38141fcb0e96d5b50776480
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8af88760aa3d4c38b6df8ba59624e3f1
Autor:
Luke R. Odell, Bobo Skillinghaug, Christof Matt, Peng Wu, Tobias Koolmeister, Matthieu Desroses, Sabin Llona‐Minguez, Olov Wallner, Thomas Helleday, Martin Scobie
Publikováno v:
European Journal of Organic Chemistry.
Autor:
Maurice Michel, Carlos Benítez-Buelga, Patricia A. Calvo, Bishoy M. F. Hanna, Oliver Mortusewicz, Geoffrey Masuyer, Jonathan Davies, Olov Wallner, Kumar Sanjiv, Julian J. Albers, Sergio Castañeda-Zegarra, Ann-Sofie Jemth, Torkild Visnes, Ana Sastre-Perona, Akhilesh N. Danda, Evert J. Homan, Karthick Marimuthu, Zhao Zhenjun, Celestine N. Chi, Antonio Sarno, Elisée Wiita, Catharina von Nicolai, Anna J. Komor, Varshni Rajagopal, Sarah Müller, Emily C. Hank, Marek Varga, Emma R. Scaletti, Monica Pandey, Stella Karsten, Hanne Haslene-Hox, Simon Loevenich, Petra Marttila, Azita Rasti, Kirill Mamonov, Florian Ortis, Fritz Schömberg, Olga Loseva, Josephine Stewart, Nicholas D’Arcy-Evans, Tobias Koolmeister, Martin Henriksson, Dana Michel, Ana de Ory, Lucia Acero, Oriol Calvete, Martin Scobie, Christian Hertweck, Ivan Vilotijevic, Christina Kalderén, Ana Osorio, Rosario Perona, Alexandra Stolz, Pål Stenmark, Ulrika Warpman Berglund, Miguel de Vega, Thomas Helleday
Publikováno v:
Science. 376:1471-1476
Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with
Autor:
Ulrika Warpman Berglund, Thomas Helleday, Julian Walfridsson, Päivi Östling, Mathew J. Garnett, Kim Theilgaard-Mönch, Sören Lehmann, Teresa Sandvall, Olov Wallner, Martin Henriksson, Tobias Koolmeister, Martin Scobie, Torkild Visnes, Nona Struyf, Thea Kristin Våtsveen, Montserrat Estruch, Anders Centio, Stefanie Friedrich, Azita Rasti, Camilla Göktürk, Elisee Wiita, Helge Gad, Akhilesh Nagesh Danda, Brinton Seashore-Ludlow, Yaser Heshmati, Andreas Höglund, Ingrid Almlöf, Viktoriia Tsuber, Tom Erkers, Therese M. Pham, José Manuel Calderón-Montaño, Kumar Sanjiv
Supplementary figures and tables and material and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280d78da8fe2c0fa692e2c21f2cc0ef
https://doi.org/10.1158/0008-5472.22490525
https://doi.org/10.1158/0008-5472.22490525
Autor:
Ulrika Warpman Berglund, Thomas Helleday, Julian Walfridsson, Päivi Östling, Mathew J. Garnett, Kim Theilgaard-Mönch, Sören Lehmann, Teresa Sandvall, Olov Wallner, Martin Henriksson, Tobias Koolmeister, Martin Scobie, Torkild Visnes, Nona Struyf, Thea Kristin Våtsveen, Montserrat Estruch, Anders Centio, Stefanie Friedrich, Azita Rasti, Camilla Göktürk, Elisee Wiita, Helge Gad, Akhilesh Nagesh Danda, Brinton Seashore-Ludlow, Yaser Heshmati, Andreas Höglund, Ingrid Almlöf, Viktoriia Tsuber, Tom Erkers, Therese M. Pham, José Manuel Calderón-Montaño, Kumar Sanjiv
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested to drive leukemogenesis and is thus a potential novel target for treating AML. MTH1 prevents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc3a2e4a790d48cfedb4902184be996
https://doi.org/10.1158/0008-5472.c.6533174.v1
https://doi.org/10.1158/0008-5472.c.6533174.v1
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop