Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Martin S. Denzel"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect
Externí odkaz:
https://doaj.org/article/239d229d7b824a359ee93d56ac13b688
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in
Externí odkaz:
https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
Autor:
Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann, Martin S. Denzel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Mutations in the hexosamine pathway key enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) improve protein quality control and extend C. elegans lifespan. Here the authors present the crystal structures of full-length human GFAT-1 alone
Externí odkaz:
https://doaj.org/article/e59e6a5f14a34fdf901be6fbcaf41cc6
Autor:
Moritz Horn, Sarah I. Denzel, Balaji Srinivasan, Kira Allmeroth, Isabelle Schiffer, Vignesh Karthikaisamy, Stephan Miethe, Peter Breuer, Adam Antebi, Martin S. Denzel
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Activation of the hexosamine pathway (HP) through gain-of-function mutations in its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) ameliorates proteotoxicity and increases lifespan in Caenorhabditis elegans. He
Externí odkaz:
https://doaj.org/article/087241d9385f4ca39e67a6ce52c26b55
Autor:
Barbara Ranscht, Robert D. Cardiff, Lawrence Shapiro, Gregory Shostak, Lionel W. Hebbard, Martin S. Denzel
Supplementary Data from Adiponectin Deficiency Limits Tumor Vascularization in the MMTV-PyV-mT Mouse Model of Mammary Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02257586e9823b243aea980b7eae03b4
https://doi.org/10.1158/1078-0432.22439314
https://doi.org/10.1158/1078-0432.22439314
Autor:
Barbara Ranscht, Robert D. Cardiff, Lawrence Shapiro, Gregory Shostak, Lionel W. Hebbard, Martin S. Denzel
Purpose: High levels of the fat-secreted cytokine adiponectin (APN) are present in the circulation of healthy people, whereas low levels correlate with an increased incidence of breast cancer in women. The current study experimentally probes the phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfc7653cbff85df556ea0edc66c21ab
https://doi.org/10.1158/1078-0432.c.6516802.v1
https://doi.org/10.1158/1078-0432.c.6516802.v1
Autor:
Laura E. Wester, Anne Lanjuin, Emanuel H.W. Bruckisch, Maria C. Perez-Matos, Peter G. Stine, Caroline Heintz, Martin S. Denzel, William B. Mair
Publikováno v:
Cell Rep Methods
Here, we introduce a single-copy knockin translating ribosome immunoprecipitation (SKI TRIP) toolkit, a collection of Caenorhabditis elegans strains engineered by CRISPR in which tissue-specific expression of FLAG-tagged ribosomal subunit protein RPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a426d2278e05a3c826cc19af3f87d
https://europepmc.org/articles/PMC10088236/
https://europepmc.org/articles/PMC10088236/
Autor:
Vasudha Tandon, Rita Moreno, Kira Allmeroth, Jean Quinn, Sandra E. Wiley, Lynden G. Nicely, Martin S. Denzel, Joanne Edwards, Laureano de la Vega, Sourav Banerjee
Publikováno v:
Biosci Rep.
Preserving proteostasis is a major survival mechanism for cancer. Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) is a key oncogenic kinase that directly activates the transcription factor heat-shock factor 1 (HSF1) and the 26S p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c2db095d9e03c1e0cfaadaa653e515
https://hdl.handle.net/21.11116/0000-000C-969A-D21.11116/0000-000C-969C-B
https://hdl.handle.net/21.11116/0000-000C-969A-D21.11116/0000-000C-969C-B
Publikováno v:
Nature Aging. 1:760-768
Healthy aging requires the coordination of numerous stress signaling pathways that converge on the protein homeostasis network. The integrated stress response (ISR) is activated by diverse stimuli, leading to phosphorylation of the eukaryotic transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd2511a2dca3e8264a2ed3e38fd8812
https://doi.org/10.1038/s43587-021-00112-9
https://doi.org/10.1038/s43587-021-00112-9
Publikováno v:
Aging Cell
Glucosamine feeding and genetic activation of the hexosamine biosynthetic pathway (HBP) have been linked to improved protein quality control and lifespan extension in various species. Thus, there is considerable interest in the potential health benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cda61d687dd31fb2862b5d4410d37f6
https://doi.org/10.1111/acel.13711
https://doi.org/10.1111/acel.13711