Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Martin S Winkler"'
Autor:
Irina Soltau, Eileen Mudersbach, Markus Geissen, Edzard Schwedhelm, Martin S Winkler, Maria Geffken, Sven Peine, Gerhard Schoen, E Sebastian Debus, Axel Larena-Avellaneda, Guenter Daum
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168302 (2016)
Atherosclerotic changes of arteries are the leading cause for deaths in cardiovascular disease and greatly impair patient's quality of life. Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates potentially pro-as well as anti-athe
Externí odkaz:
https://doaj.org/article/37e5f5da0c354e7a81a769f9a4a4fac7
Autor:
Martin S. Winkler, Marcin F. Osuchowski, Didier Payen, Antoni Torres, Steffen Dickel, Tomasz Skirecki
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-9 (2022)
Abstract The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established. This may constitute a harbinger
Externí odkaz:
https://doaj.org/article/d92257ae52944d7ba25583a50b151b7b
Autor:
Martin Lier, Stefan Nessler, Christine Stadelmann, Meike Pressler, Leif Saager, Onnen Moerer, Markus Roessler, Konrad Meissner, Martin S. Winkler
Publikováno v:
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 29, Iss 1, Pp 1-8 (2021)
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious airborne virus inducing pandemic coronavirus disease 2019 (COVID-19). This is most relevant for medical staff working under harmful conditions in
Externí odkaz:
https://doaj.org/article/75f07f3a1ee8482aa233986f6ebc10e1
Autor:
Markus Hoffmann, Anzhalika Sidarovich, Prerna Arora, Nadine Krüger, Inga Nehlmeier, Amy Kempf, Luise Graichen, Martin S. Winkler, Daniela Niemeyer, Christine Goffinet, Christian Drosten, Sebastian Schulz, Hans-Martin Jäck, Stefan Pöhlmann
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT SARS-CoV-2 variants of concern (VOC) acquired mutations in the spike (S) protein, including E484K, that confer resistance to neutralizing antibodies. However, it is incompletely understood how these mutations impact viral entry into host cel
Externí odkaz:
https://doaj.org/article/b456191be4ea4ac29d1a309a4697f9af
Autor:
Prerna Arora, Amy Kempf, Inga Nehlmeier, Luise Graichen, Martin S. Winkler, Martin Lier, Sebastian Schulz, Hans-Martin Jäck, Anne Cossmann, Metodi V. Stankov, Georg M.N. Behrens, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110754- (2022)
Summary: Rapid spread of SARS-CoV-2 variants C.1.2 and B.1.621 (Mu variant) in Africa and the Americas, respectively, as well as a high number of mutations in the viral spike proteins raised concerns that these variants might pose an elevated threat
Externí odkaz:
https://doaj.org/article/1fb852d0d9bb437db843675916e4b705
Autor:
Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Markus H. Gräler, Ralf A. Claus
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair. As demonstrat
Externí odkaz:
https://doaj.org/article/ffd281b80d554c438e499f3120e6ff91
Autor:
Prerna Arora, Lu Zhang, Cheila Rocha, Luise Graichen, Inga Nehlmeier, Amy Kempf, Anne Cossmann, Gema Morillas Ramos, Eva Baier, Björn Tampe, Onnen Moerer, Steffen Dickel, Martin S. Winkler, Georg M. N. Behrens, Stefan Pöhlmann, Markus Hoffmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14057 (2022)
Recently, a recombinant SARS-CoV-2 lineage, XD, emerged that harbors a spike gene that is largely derived from the Omicron variant BA.1 in the genetic background of the Delta variant. This finding raised concerns that the recombinant virus might exhi
Externí odkaz:
https://doaj.org/article/14c4ce1145744cba81384e99b38a7b6f
Autor:
Gillis Greiwe, Moritz Flick, Alexander Hapfelmeier, Martin S. Winkler, Rainer Nitzschke, Daniel Frings, Bernd Saugel
Publikováno v:
European Journal of Anaesthesiology. 40:436-441
Autor:
Martin S. Winkler, Tomasz Skirecki, Frank M. Brunkhorst, Sara Cajander, Jean-Marc Cavaillon, Ricard Ferrer, Stefanie B. Flohé, Alberto García-Salido, Evangelos J. Giamarellos-Bourboulis, Massimo Girardis, Matthijs Kox, Gunnar Lachmann, Ignacio Martin-Loeches, Mihai G. Netea, Thibaud Spinetti, Joerg C. Schefold, Antoni Torres, Florian Uhle, Fabienne Venet, Sebastian Weis, André Scherag, Ignacio Rubio, Marcin F. Osuchowski
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103291- (2021)
Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been de
Externí odkaz:
https://doaj.org/article/98f8d9930d774bf882699ae84368420a
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1841 (2021)
In critically ill patients, liver dysfunction often results in coagulopathy and encephalopathy and is associated with high mortality. Extracorporeal clearance of hepatotoxic metabolites, including bilirubin and ammonia, aims to attenuate further hepa
Externí odkaz:
https://doaj.org/article/0fe09fa3f6384df0a8ce0f2195cabcef