Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Martin S King"'
Autor:
Eva Pyrihová, Martin S King, Alannah C King, M Rey Toleco, Mark van der Giezen, Edmund RS Kunji
Publikováno v:
eLife, Vol 13 (2024)
Stramenopiles form a clade of diverse eukaryotic organisms, including multicellular algae, the fish and plant pathogenic oomycetes, such as the potato blight Phytophthora, and the human intestinal protozoan Blastocystis. In most eukaryotes, glycolysi
Externí odkaz:
https://doaj.org/article/040840958fc04129a766c27f135ad4e1
Autor:
Homa Majd, Martin S King, Shane M Palmer, Anthony C Smith, Liam DH Elbourne, Ian T Paulsen, David Sharples, Peter JF Henderson, Edmund RS Kunji
Publikováno v:
eLife, Vol 7 (2018)
Substrates of most transport proteins have not been identified, limiting our understanding of their role in physiology and disease. Traditional identification methods use transport assays with radioactive compounds, but they are technically challengi
Externí odkaz:
https://doaj.org/article/3d8a53754a354007b923756d93ee1ba3
Autor:
Frank Maldarelli, Sarah Palmer, Martin S King, Ann Wiegand, Michael A Polis, JoAnn Mican, Joseph A Kovacs, Richard T Davey, Diane Rock-Kress, Robin Dewar, Shuying Liu, Julia A Metcalf, Catherine Rehm, Scott C Brun, George J Hanna, Dale J Kempf, John M Coffin, John W Mellors
Publikováno v:
PLoS Pathogens, Vol 3, Iss 4, p e46 (2007)
Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of
Externí odkaz:
https://doaj.org/article/d12783e8e17c4822bde2560ae3f5522f
Autor:
Vasiliki Mavridou, Martin S. King, Sotiria Tavoulari, Jonathan J. Ruprecht, Shane M. Palmer, Edmund R. S. Kunji
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The mitochondrial ADP/ATP carrier transports adenine nucleotides. Here, authors identify the residues involved in substrate binding. One set forms the central substrate binding site and two asparagine/arginine pairs help to guide the substrates durin
Externí odkaz:
https://doaj.org/article/a4a0d085f23f4c14a0e50b7bdf2ecf0d
Autor:
Scott A. Jones, Prerana Gogoi, Jonathan J. Ruprecht, Martin S. King, Yang Lee, Thomas Zögg, Els Pardon, Deepak Chand, Stefan Steimle, Danielle M. Copeman, Camila A. Cotrim, Jan Steyaert, Paul G. Crichton, Vera Moiseenkova-Bell, Edmund R. S. Kunji
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial inner me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392b3065dd9b3ad5eedf86e515683f81
https://doi.org/10.1126/sciadv.adh4251
https://doi.org/10.1126/sciadv.adh4251
Autor:
Martin S. King, Sotiria Tavoulari, Vasiliki Mavridou, Alannah C. King, John Mifsud, Edmund R. S. Kunji
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8971 (2020)
Cryptosporidiumparvum is a clinically important eukaryotic parasite that causes the disease cryptosporidiosis, which manifests with gastroenteritis-like symptoms. The protist has mitosomes, which are organelles of mitochondrial origin that have only
Externí odkaz:
https://doaj.org/article/a0a16d23e2044cf1a465d5bf2ec4cb58
Autor:
Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji
Publikováno v:
Molecular Metabolism, 60
Molecular metabolism, 60:101469. ELSEVIER SCIENCE BV
Molecular metabolism, 60:101469. ELSEVIER SCIENCE BV
OBJECTIVE: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. A range of struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2d9533a0720af38d74135f59a47705
https://pubmed.ncbi.nlm.nih.gov/35278701
https://pubmed.ncbi.nlm.nih.gov/35278701
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1863:148731
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f75277526a59f48c005efe085f408b
https://doi.org/10.1016/j.bbabio.2022.148731
https://doi.org/10.1016/j.bbabio.2022.148731
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2168
There are very few generic methods to assess the stability and functional properties of membrane proteins solubilized in detergent. For this purpose, a thiol-reactive fluorochrome N-[4-(7-diethylamino-4-methyl-3-coumarinyl)phenyl]maleimide (CPM) can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b9437cc46d715750a06320e027fab2c
https://pubmed.ncbi.nlm.nih.gov/33582989
https://pubmed.ncbi.nlm.nih.gov/33582989
Publikováno v:
Theranostics, 11, 11, pp. 5077-5091
Theranostics
Theranostics, 11, 5077-5091
Theranostics
Theranostics, 11, 5077-5091
An increasing number of commonly prescribed drugs are known to interfere with mitochondrial function, causing cellular toxicity, but the underlying mechanisms are largely unknown. Although often not considered, mitochondrial transport proteins form a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0938d3c72e4542ace4b7836c6563765a
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/232028
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/232028