Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

Autor: Christina Dahl, Christer Lundell-Ek, Henrik J. Ditzel, Jann Mortensen, Karine N. Dzhandzhugazyan, Line Bille Madsen, Johnny Jon Fang, Helle Broholm, Walter Fischer, Morten F. Gjerstorff, Tim Lundby, Ian Law, Per Guldberg, Rikke Sick Andersen, Martin Roland Jensen, Alexei F. Kirkin, Aase Wagner

Publikováno v: Kirkin, A F, Dzhandzhugazyan, K N, Guldberg, P, Fang, J J, Andersen, R S, Dahl, C, Mortensen, J, Lundby, T, Wagner, A, Law, I, Broholm, H, Madsen, L, Lundell-Ek, C, Gjerstorff, M F, Ditzel, H J, Jensen, M R & Fischer, W 2018, ' Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells ', Nature Communications, vol. 9, 785 . https://doi.org/10.1038/s41467-018-03217-9
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Kirkin, A F, Dzhandzhugazyan, K N, Guldberg, P, Fang, J J, Andersen, R S, Dahl, C, Mortensen, J, Lundby, T, Wagner, A, Law, I, Broholm, H, Madsen, L, Lundell-Ek, C, Gjerstorff, M F, Ditzel, H J, Jensen, M R & Fischer, W 2018, ' Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells ', Nature Communications, vol. 9, no. 1, 785 . https://doi.org/10.1038/s41467-018-03217-9

In cancer cells, cancer/testis (CT) antigens become epigenetically derepressed through DNA demethylation and constitute attractive targets for cancer immunotherapy. Here we report that activated CD4+ T helper cells treated with a DNA-demethylating ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2073161fab54b049c7d89cd5b4119cc
https://doi.org/10.1038/s41467-018-03217-9

Transcriptional regulation of the four promoters of the agarase gene (dagA) of Streptomyces coelicolor A3 (2)

Autor: Luis Servín-González, Janet White, Martin Roland Jensen, Mervyn J. Bibb

Publikováno v: Microbiology. 140:2555-2565

The agarase gene (dagA) of Streptomyces coelicolor A3(2) is transcribed from four promoters that are recognized by at least three, and probably four, different RNA polymerase holoenzymes, each containing a different sigma factor. S1 nuclease protecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba730f9f30416c14b81c85afa6fce9d
https://doi.org/10.1099/00221287-140-10-2555

Escherichia coli minichromosomes: Random segregation and absence of copy number control

Autor: Martin Roland Jensen, Anders Løbner-Olesen, Knud V. Rasmussen

Publikováno v: Journal of Molecular Biology. 215:257-265

Minichromosomes, i.e. plasmids that can replicate from an integrated oriC, have been puzzling because of their high copy numbers compared to that of the chromosomal oriC, their lack of incompatibility with the chromosome and their high loss frequenci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0199e9d348b7809a1776c034b61a800b
https://doi.org/10.1016/s0022-2836(05)80344-4

Comparison of different signal peptides for secretion of heterologous proteins in fission yeast

Autor: Søren Kjærulff, Martin Roland Jensen

Publikováno v: Biochemical and biophysical research communications. 336(3)

In the fission yeast Schizosaccharomyces pombe, there are relatively few signal peptides available and most reports of their activity have not been comparative. Using sequence information from the S. pombe genome database we have identified three put

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684e9991039917c03d7425de4af2b93f
https://pubmed.ncbi.nlm.nih.gov/16157307