Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Martin R. Jakobsen"'
Autor:
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling
Externí odkaz:
https://doaj.org/article/d5f211afbe2146aea0d8433928886c3f
Autor:
Lamin B. Cham, Jesper D. Gunst, Mariane H. Schleimann, Giacomo S. Frattari, Miriam Rosas-Umbert, Line K. Vibholm, Renée M. van der Sluis, Martin R. Jakobsen, Rikke Olesen, Lin Lin, Martin Tolstrup, Ole S. Søgaard
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107628- (2023)
Summary: Human plasmacytoid dendritic cells (pDCs) play a central role in initiating and activating host immune responses during infection. To understand how the transcriptome of pDCs is impacted by HIV-1 infection and exogenous stimulation, we isola
Externí odkaz:
https://doaj.org/article/c71981a857e54b519eb37f5423105348
Autor:
Aida S. Hansen, Lea S. Jensen, Kristine R. Gammelgaard, Kristoffer G. Ryttersgaard, Christian Krapp, Jesper Just, Kasper L. Jønsson, Pia B. Jensen, Thomas Boesen, Mogens Johannsen, Anders Etzerodt, Bent W. Deleuran, Martin R. Jakobsen
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract A key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumour recognition and hence hereof tumour eradication, the majori
Externí odkaz:
https://doaj.org/article/243433d9b85349ca81ff3bd193a23e6f
Autor:
Ditte Køster, Johanne Hovgaard Egedal, Søren Lomholt, Malene Hvid, Martin R. Jakobsen, Ulf Müller-Ladner, Hermann Eibel, Bent Deleuran, Tue Wenzel Kragstrup, Elena Neumann, Morten Aagaard Nielsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Fibroblast-like synoviocytes (FLS) play an important pathological role in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). These cells have primarily been characterized in the RA synovial membrane. Here we aim to phe
Externí odkaz:
https://doaj.org/article/534b11d35cf043f5b6353f63fbcc17d0
Autor:
Jesper G. Pedersen, Johanne H. Egedal, Thomas A. Packard, Karthiga Thavachelvam, Guorui Xie, Renée Marije van der Sluis, Warner C. Greene, Nadia R. Roan, Martin R. Jakobsen
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28 in vitro stimulation protocol to render CD4+
Externí odkaz:
https://doaj.org/article/645cdc5c0c3440dcb09dfb4688ca1a1b
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Dendritic cells (DCs) play a critical role in mediating innate and adaptive immune responses. Since their discovery in the late 1970's, DCs have been recognized as the most potent antigen-presenting cells (APCs). DCs have a superior capacity for acqu
Externí odkaz:
https://doaj.org/article/9ffa81afbf7e4e31a996d0c9fe86d8b5
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2092-2104.e10 (2019)
Summary: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the human
Externí odkaz:
https://doaj.org/article/23fcf6a2dd424c5193317bfaa8ba1f2e
Autor:
Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus
Externí odkaz:
https://doaj.org/article/00f2e460d4a44590a591e3a422a9f087
Autor:
Jacqueline K. Flynn, Geza Paukovics, Kieran Cashin, Katharina Borm, Anne Ellett, Michael Roche, Martin R. Jakobsen, Melissa J. Churchill, Paul R. Gorry
Publikováno v:
Viruses, Vol 6, Iss 2, Pp 709-726 (2014)
CD4+ T cells are principal targets for human immunodeficiency virus type 1 (HIV-1) infection. CD4+ T cell subsets are heterogeneous cell populations, divided by functional and phenotypic differences into naïve and memory T cells. The memory CD4+ T c
Externí odkaz:
https://doaj.org/article/8b31d71c2f8e493495258edab61a00e6