Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Martin R. Gluck"'
Autor:
Kelly A. Hogan, Lawrence Manzino, Patricia K. Sonsalla, Elizabeth Jayatilleke, Martin R. Gluck, Lily Y. Moy
Publikováno v:
Journal of Neurochemistry. 79:152-160
The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive oxygen species (ROS). Methamphetamine administration leads to increases in ROS formation and lipid peroxidation in rodent brain; however, the extent to which protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f2dc7e8cdc4860cb5d8b09d6cbf8884
https://doi.org/10.1046/j.1471-4159.2001.00549.x
https://doi.org/10.1046/j.1471-4159.2001.00549.x
Autor:
Gail D. Zeevalk, Martin R. Gluck
Publikováno v:
Journal of Neurochemistry. 91:788-795
A structure-potency study examining the ability of dopamine (DA), its major metabolites and related amine and acetate congeners to inhibit NADH-linked mitochondrial O(2) consumption was carried out to elucidate mechanisms by which DA could induce mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43affc9858776547cf906e1df402d789
https://doi.org/10.1111/j.1471-4159.2004.02747.x
https://doi.org/10.1111/j.1471-4159.2004.02747.x
Publikováno v:
Journal of Neurochemistry. 63:655-661
1-Methyl-4-phenylpyridinium (MPP+), the toxic agent in MPTP-induced dopaminergic neurotoxicity, is thought to act by inhibiting mitochondrial electron transport at complex I. This study examined this latter action further with a series of 4'-alkylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc5c7afdca8d9b09db785985064f80e
https://doi.org/10.1046/j.1471-4159.1994.63020655.x
https://doi.org/10.1046/j.1471-4159.1994.63020655.x
Publikováno v:
Parkinsonism & Related Disorders. 8:395-400
Glutaredoxin (Grx) is a specific and efficient catalyst of glutathione-dependent deglutathionylation of protein-SS-glutathione mixed disulfides. Grx has been identified in brain cytosol, but the presence of activity in subcellular organelles has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06c3e5fe9386adedc33ebcda313cfb2
https://doi.org/10.1016/s1353-8020(02)00020-2
https://doi.org/10.1016/s1353-8020(02)00020-2
Publikováno v:
American Journal of Psychiatry. 159:1165-1173
Pharmacological, clinical, and postmortem studies suggest altered gamma-aminobutyric acid (GABA)-ergic and glutamatergic function in patients with schizophrenia. The dorsolateral prefrontal cortex is one key locus of abnormality. The precise neuroche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfcae82b2c67742d59503fedc9a5ce3
https://doi.org/10.1176/appi.ajp.159.7.1165
https://doi.org/10.1176/appi.ajp.159.7.1165
Publikováno v:
Journal of Neurochemistry. 82:66-74
Examination of the downstream mediators responsible for inhibition of mitochondrial respiration by dopamine (DA) was investigated. Consistent with findings reported by others, exposure of rat brain mitochondria to 0.5 mm DA for 15 min at 30°C inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23c3f9657a9d464262fb44a329c4b2f
https://doi.org/10.1046/j.1471-4159.2002.00938.x
https://doi.org/10.1046/j.1471-4159.2002.00938.x
Publikováno v:
Biochemical and Biophysical Research Communications. 169:758-764
1-Methyl-4-phenylpyridinium ion, a major brain metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, is an inhibitor of Complex I of the mitochondrial respiratory chain. We have synthesized several analogs of 1-methyl-4-phenylpyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5844d6b34c201742b883932d2780516a
https://doi.org/10.1016/0006-291x(90)90396-5
https://doi.org/10.1016/0006-291x(90)90396-5
Autor:
Martin R Gluck
Parkinson s disease (PD) is a common chronic neurodegenerative disorder affecting one per one hundred adults over age 50. The underlying cause(s) of PD remain unknown. Dr. Cohen, the original recipient of the grant, titled Parkinson s Disease; the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7db871ad11654d713e91d41c65a0a8f
https://doi.org/10.21236/ada612171
https://doi.org/10.21236/ada612171
Autor:
Martin R Gluck
Dr G. Cohen: The original intent of the grant, as proposed by the principle investigator, Dr. 0. Cohen, was to examine the ability of monoamine oxidase- associated substrates such as dopamine and tyramine to inhibit mitochondrial respiration. The stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d27daaf0b3d84efc907bf1f13d0b44
https://doi.org/10.21236/ada418651
https://doi.org/10.21236/ada418651
Publikováno v:
Epilepsy research. 39(1)
The role of oxidative stress in seizure-induced brain injury was investigated in a kainic acid model of experimental epilepsy. Kainic acid (12.5 mg/kg) or saline was injected intraperitoneally into 12-week-old male Fischer 344 rats and sacrificed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfb2273f7a9a1d143eecdb2b42d1a5c
https://pubmed.ncbi.nlm.nih.gov/10690755
https://pubmed.ncbi.nlm.nih.gov/10690755