Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Martin R, Sprick"'
Autor:
Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity
Externí odkaz:
https://doaj.org/article/e4d4ca03df544a909e2ed53aef5fd83a
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-2 (2021)
Abstract Ovarian cancer has the worst prognosis of all gynecological cancers with high‐grade serous ovarian cancer (HGSOC) accounting for the majority of ovarian cancer deaths. Therapy resistance and the selection of effective therapies for patient
Externí odkaz:
https://doaj.org/article/b3265540fef94034b9ed82f7661efcd6
Autor:
Mandar Deepak Muzumdar, Pan-Yu Chen, Kimberly Judith Dorans, Katherine Minjee Chung, Arjun Bhutkar, Erin Hong, Elisa M. Noll, Martin R. Sprick, Andreas Trumpp, Tyler Jacks
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an import
Externí odkaz:
https://doaj.org/article/4d398db26f7f440fbdb14fc260d45e14
Autor:
Sebastian Horn, Michelle A. Hughes, Ramon Schilling, Carsten Sticht, Tencho Tenev, Michaela Ploesser, Pascal Meier, Martin R. Sprick, Marion MacFarlane, Martin Leverkus
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 785-797 (2017)
Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD. By elucidating the function of the caspase-8 homolog, caspase-1
Externí odkaz:
https://doaj.org/article/0ad9bd0b10b4416e8f23ed9dcbc41e81
Autor:
Andreas Trumpp, Martin R. Sprick, Wilko Weichert, Oliver Strobel, Janel L. Kopp, Ilse Rooman, H. Efsun Arda, Dieter Weichenhan, Katja Steiger, Benedikt Brors, Christoph Plass, Thilo Hackert, Nicole Pfarr, Matthias Schlesner, Roland Eils, Hsi-Yu Yen, Elisa Donato, Manuel Rodríguez-Paredes, Matthias M. Gaida, Soheila Zarei, Elyne Backx, Alex Y.L. Lee, Karnjit Sarai, Alexander Muckenhuber, Steffi O. Kossi, Vera Thiel, Manuel Reitberger, Jacob Insua-Rodríguez, Mattia Falcone, Vanessa Vogel, Corinna Klein, Silke Weisenburger, Mariam Safavi, Magdalena Büscher, Nathalia A. Giese, Charles D. Imbusch, Zuguang Gu, Elisa Espinet
MC2vsMC1 DMRs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785836b13a490de9f0896841ccdfcf61
https://doi.org/10.1158/2159-8290.22536154
https://doi.org/10.1158/2159-8290.22536154
Autor:
Andreas Trumpp, Martin R. Sprick, Wilko Weichert, Oliver Strobel, Janel L. Kopp, Ilse Rooman, H. Efsun Arda, Dieter Weichenhan, Katja Steiger, Benedikt Brors, Christoph Plass, Thilo Hackert, Nicole Pfarr, Matthias Schlesner, Roland Eils, Hsi-Yu Yen, Elisa Donato, Manuel Rodríguez-Paredes, Matthias M. Gaida, Soheila Zarei, Elyne Backx, Alex Y.L. Lee, Karnjit Sarai, Alexander Muckenhuber, Steffi O. Kossi, Vera Thiel, Manuel Reitberger, Jacob Insua-Rodríguez, Mattia Falcone, Vanessa Vogel, Corinna Klein, Silke Weisenburger, Mariam Safavi, Magdalena Büscher, Nathalia A. Giese, Charles D. Imbusch, Zuguang Gu, Elisa Espinet
Supplementary Figures S1 to S15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6bcfdd799ab0ad68bc5c33c677dcd0
https://doi.org/10.1158/2159-8290.22536175.v1
https://doi.org/10.1158/2159-8290.22536175.v1
Autor:
Frank Winkler, Wolfgang Wick, Matthias Preusser, Patricia S. Steeg, Andreas Trumpp, Miriam Ratliff, Carina M. Thome, Petra Rübmann, Lulu Huang, Miriam Gömmel, Gergely Solecki, Michael O. Breckwoldt, Natalia Becker, Felix Sahm, Zuszanna Bago-Horvath, Laura L. Michel, Frederic Marmé, Brunhilde Gril, Manuel Feinauer, Susanne Wünsche, Matthias Osswald, Tobias Kessler, Christian Eisen, Martin R. Sprick, Katharina Gunkel, Ayseguel Ilhan-Mutlu, Matthia A. Karreman, Yunxiang Liao, Anna. S. Berghoff
Specific biological properties of those circulating cancer cells that are the origin of brain metastases (BM) are not well understood. Here, single circulating breast cancer cells were fate-tracked during all steps of the brain metastatic cascade in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4430eee691997f3dfbf7daec9f854e4b
https://doi.org/10.1158/1541-7786.c.6545246.v1
https://doi.org/10.1158/1541-7786.c.6545246.v1
Autor:
Andreas Trumpp, Martin R. Sprick, Wilko Weichert, Oliver Strobel, Janel L. Kopp, Ilse Rooman, H. Efsun Arda, Dieter Weichenhan, Katja Steiger, Benedikt Brors, Christoph Plass, Thilo Hackert, Nicole Pfarr, Matthias Schlesner, Roland Eils, Hsi-Yu Yen, Elisa Donato, Manuel Rodríguez-Paredes, Matthias M. Gaida, Soheila Zarei, Elyne Backx, Alex Y.L. Lee, Karnjit Sarai, Alexander Muckenhuber, Steffi O. Kossi, Vera Thiel, Manuel Reitberger, Jacob Insua-Rodríguez, Mattia Falcone, Vanessa Vogel, Corinna Klein, Silke Weisenburger, Mariam Safavi, Magdalena Büscher, Nathalia A. Giese, Charles D. Imbusch, Zuguang Gu, Elisa Espinet
Extended Data Figures 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c97adeb289208dbcf1166e0d17a68
https://doi.org/10.1158/2159-8290.22536181
https://doi.org/10.1158/2159-8290.22536181
Autor:
Andreas Trumpp, Martin R. Sprick, Wilko Weichert, Oliver Strobel, Janel L. Kopp, Ilse Rooman, H. Efsun Arda, Dieter Weichenhan, Katja Steiger, Benedikt Brors, Christoph Plass, Thilo Hackert, Nicole Pfarr, Matthias Schlesner, Roland Eils, Hsi-Yu Yen, Elisa Donato, Manuel Rodríguez-Paredes, Matthias M. Gaida, Soheila Zarei, Elyne Backx, Alex Y.L. Lee, Karnjit Sarai, Alexander Muckenhuber, Steffi O. Kossi, Vera Thiel, Manuel Reitberger, Jacob Insua-Rodríguez, Mattia Falcone, Vanessa Vogel, Corinna Klein, Silke Weisenburger, Mariam Safavi, Magdalena Büscher, Nathalia A. Giese, Charles D. Imbusch, Zuguang Gu, Elisa Espinet
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia, which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified epithelial cells from human PDAC and normal pancreas and derived their genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ff5ab73e90d65d7b26c0856dff1192
https://doi.org/10.1158/2159-8290.c.6548059.v1
https://doi.org/10.1158/2159-8290.c.6548059.v1
Autor:
Frank Winkler, Wolfgang Wick, Matthias Preusser, Patricia S. Steeg, Andreas Trumpp, Miriam Ratliff, Carina M. Thome, Petra Rübmann, Lulu Huang, Miriam Gömmel, Gergely Solecki, Michael O. Breckwoldt, Natalia Becker, Felix Sahm, Zuszanna Bago-Horvath, Laura L. Michel, Frederic Marmé, Brunhilde Gril, Manuel Feinauer, Susanne Wünsche, Matthias Osswald, Tobias Kessler, Christian Eisen, Martin R. Sprick, Katharina Gunkel, Ayseguel Ilhan-Mutlu, Matthia A. Karreman, Yunxiang Liao, Anna. S. Berghoff
Supplementary Figure 3 shows PKH26 intensity and depth of the cell in relation to the successful establishment of a metastasis. Further, the brain metastatic cascade for PKH26 low (slow cycling) and PKH26 (high) (ultra slow cycling) cells is illustra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c4f4c45bd22576427dc0818fd7bd65
https://doi.org/10.1158/1541-7786.22526921.v1
https://doi.org/10.1158/1541-7786.22526921.v1