Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Martin Puskarjov"'
Autor:
Janine R Neumann, Suvarna Dash-Wagh, Alexander Jack, Andrea Räk, Kay Jüngling, Mohammad I K Hamad, Hans-Christian Pape, Michael R Kreutz, Martin Puskarjov, Petra Wahle
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211151 (2019)
The 30-amino acid peptide Y-P30 corresponds to the N-terminus of the primate-specific, sweat gland-derived dermcidin prepropeptide. Previous work has revealed that Y-P30 enhances the interaction of pleiotrophin and syndecans-2/3, and thus represents
Externí odkaz:
https://doaj.org/article/5c2988e9542a4f6f8a161ca1f6c5a2f6
Autor:
Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1073-1081.e3 (2019)
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/9eed9b7af8d2422995f9f960e42d3162
Publikováno v:
Acta Physiologica. 229
Aim To study brain-sparing physiological responses in a rodent model of birth asphyxia which reproduces the asphyxia-defining systemic hypoxia and hypercapnia. Methods Steady or intermittent asphyxia was induced for 15-45 min in anesthetized 6- and 1
Loss of non‐canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons
Publikováno v:
EMBO Rep
KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl-) extruder critical for hyperpolarizing GABA(A) receptor currents. Independently of its canonical function as a K-Cl co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5199543e80bb8bb52c2871214a9a25f
https://europepmc.org/articles/PMC7132201/
https://europepmc.org/articles/PMC7132201/
Autor:
Karl Deisseroth, Jenna Lindfors, Brian Hsueh, Patricia Seja, Inkeri Spoljaric, Juha Voipio, Ailey K. Crow, Martin Puskarjov, Kai Kaila, Eva Ruusuvuori, Pavel Uvarov, Albert Spoljaric, Mari A. Virtanen, Milla Summanen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The transition from placental to lung-based oxygen supply at mammalian birth involves an obligatory period of asphyxia, which is further aggravated by complications during delivery. This oxygen deprivation is a major threat to the fetal
Autor:
Kai Kaila, Laszlo Vutskits, Hubert Fiumelli, Adrian Briner, Kornél Demeter, Martin Puskarjov, Peter Blaesse, Claudia-Marvine Lacoh, Timea Bodogan, Martina Mavrovic
Publikováno v:
Anesthesiology, Vol. 126, No 5 (2017) pp. 855-867
Background General anesthetics potentiating γ-aminobutyric acid (GABA)–mediated signaling are known to induce a persistent decrement in excitatory synapse number in the cerebral cortex when applied during early postnatal development, while an oppo
Autor:
Donald Thevalingam, Daniel P. McCloskey, Edward F. Meehan, Martin Puskarjov, Michael Kress, Kai Kaila, Edmund C. Jenkins, Michael Zions
Publikováno v:
Current biology : CB. 30(11)
African naked mole-rats were likely the first mammals to evolve eusociality, and thus required adaptations to conserve energy and tolerate the low oxygen (O-2) and high carbon dioxide (CO2) of a densely populated fossorial nest. As hypercapnia is kno
Autor:
Kai Kaila, Kerstin Römermann, Pauliina Paavilainen, Trine Lisberg Toft-Bertelsen, Andi Kipper, Peter W. Feit, Inkeri Spoljaric, Wolfgang Löscher, Martin Puskarjov, Patricia Seja, Nanna MacAulay, Kathrin Töllner, Markus Kalesse, Philip Hampel, Claudia Brandt, Kasper Lykke
Correction Volume: 143 Pages: 349-350 DOI: 10.1016/j.neuropharm.2018.10.012 Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and NKCC2, has been t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb498b43ac7a92429d3b6c29ccfcc27
http://hdl.handle.net/10138/312515
http://hdl.handle.net/10138/312515
Autor:
Philip Hampel, Peter W. Feit, Trine Lisberg Toft-Bertelsen, Inkeri Spoljaric, Markus Kalesse, Kasper Lykke, Kerstin Römermann, Wolfgang Löscher, Patricia Seja, Kathrin Töllner, Martin Puskarjov, Andi Kipper, Pauliina Paavilainen, Nanna MacAulay, Kai Kaila, Claudia Brandt
Publikováno v:
Neuropharmacology. 143
Publikováno v:
SSRN Electronic Journal.
It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that chloride regulation is dominated by Cl- uptake on the Na-K-2Cl cotransporter NKCC1. Here we demonstrate robust enh