Sex-specific effects of Cre expression in Syn1Cre mice

Autor: Maarouf Baghdadi, Andrea Mesaros, Martin Purrio, Linda Partridge

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The Cre-loxP system has been used to generate cell-type specific mutations in mice, allowing researchers to investigate the underlying biological mechanisms of disease. However, the Cre-recombinase alone can induce phenotypes that confound c

Externí odkaz: https://doaj.org/article/b028f22cecb945f2b689e00e34a8a555

Hexosamine pathway activation improves memory but does not extend lifespan in mice

Autor: Kira Allmeroth, Matías D. Hartman, Martin Purrio, Andrea Mesaros, Martin S. Denzel

Publikováno v: Aging Cell

Glucosamine feeding and genetic activation of the hexosamine biosynthetic pathway (HBP) have been linked to improved protein quality control and lifespan extension in various species. Thus, there is considerable interest in the potential health benef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cda61d687dd31fb2862b5d4410d37f6
https://doi.org/10.1111/acel.13711

Dnmt3a2/Dnmt3L Overexpression in the Dopaminergic System of Mice Increases Exercise Behavior through Signaling Changes in the Hypothalamus

Autor: Yvonne Hinze, Andrea Mesaros, Yayoi Obata, Martin Purrio, Bernd Neumaier, Gregor Burdeos, Ingo Voigt, Heike Endepols, Xiangru Xu, Alexander Drzezga, Patrick Giavalisco, Di Cui

Publikováno v: Int J Mol Sci
International Journal of Molecular Sciences, Vol 21, Iss 6297, p 6297 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 17
International journal of molecular sciences 21(17), 6297-(2020). doi:10.3390/ijms21176297

Dnmt3a2, a de novo DNA methyltransferase, is induced by neuronal activity and participates in long-term memory formation with the increased expression of synaptic plasticity genes. We wanted to determine if Dnmt3a2 with its partner Dnmt3L may influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0124934931280be12a95dd7fb4415d32
https://pubmed.ncbi.nlm.nih.gov/32878077

Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus

Autor: Werner Kilb, Maurice R. Elphick, Matthias Klugmann, Stephan Guggenhuber, Heiko J. Luhmann, Nadine Kaiser, Martin Purrio, Krisztina Monory, Rongqing Chen, Beat Lutz, Tibor Harkany, Melanie Wickert, Anne E. Harasta, Alán Alpár, Tobias Mattheus, Nina Schmitz

Publikováno v: Brain Struct Funct

The cannabinoid type 1 receptor (Cnr1, CB1R) mediates a plethora of physiological functions in the central nervous system as a presynaptic modulator of neurotransmitter release. The recently identified cannabinoid receptor-interacting protein 1a (Cnr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c637e2c0e49c97a685958de9174655
https://doi.org/10.1007/s00429-015-1027-6

Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission

Autor: Maria-Paz Viveros, Alejandro Aparisi Rey, Martin Purrio, Beat Lutz

Publikováno v: Neuropsychopharmacology

Biphasic effects of cannabinoids have been shown in processes such as feeding behavior, motor activity, motivational processes and anxiety responses. Using two different tests for the characterization of anxiety-related behavior (elevated plus-maze a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fcc96ea1530234ff0da05fa9762132
https://hdl.handle.net/21.11116/0000-000B-72BD-0