Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Martin Pule"'
Autor:
Mathieu Ferrari, Matteo Righi, Vania Baldan, Patrycja Wawrzyniecka, Anna Bulek, Alexander Kinna, Biao Ma, Reyisa Bughda, Zulaikha Akbar, Saket Srivastava, Isaac Gannon, Mathew Robson, James Sillibourne, Ram Jha, Mohamed El-Kholy, Oliver Muhammad Amin, Evangelia Kokalaki, Mohammed Amin Banani, Rehan Hussain, William Day, Wen Chean Lim, Priyanka Ghongane, Jade R. Hopkins, Dennis Jungherz, Marco Herling, Martin Welin, Sachin Surade, Michael Dyson, John McCafferty, Derek Logan, Shaun Cordoba, Simon Thomas, Andrew Sewell, Paul Maciocia, Shimobi Onuoha, Martin Pule
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches.
Externí odkaz:
https://doaj.org/article/0a0cba1c19b24f4e8e75069f7a2b0924
Autor:
Rosie Woodruff, Farhaan Parekh, Katarina Lamb, Leila Mekkaoui, Christopher Allen, Katerina Smetanova, Jasmine Huang, Alex Williams, Gerardo Santiago Toledo, Koki Lilova, Claire Roddie, James Sillibourne, Martin Pule
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101123- (2023)
Base editing is a revolutionary gene-editing technique enabling the introduction of point mutations into the genome without generating detrimental DNA double-stranded breaks. Base-editing enzymes are commonly delivered in the form of modified linear
Externí odkaz:
https://doaj.org/article/d64ddca434ba43a18b1b128f94a63b4e
Autor:
Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew Robson, Katarina Lamb, Christopher Allen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 603-621 (2023)
The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TN
Externí odkaz:
https://doaj.org/article/3161044ecdb64eac92495eea73fe8a62
Autor:
Leila Mekkaoui, Jose G. Tejerizo, Sara Abreu, Lydie Rubat, Aleksandra Nikoniuk, William Macmorland, Claire Horlock, Sofia Matsumoto, Sarah Williams, Koval Smith, Juliet Price, Saket Srivastava, Rehan Hussain, Mohammad Amin Banani, William Day, Elena Stevenson, Meghan Madigan, Jie Chen, Ravin Khinder, Shahed Miah, Simon Walker, Michael Ade-Onojobi, Sabine Domining, James Sillibourne, Marianna Sabatino, Vladimir Slepushkin, Farzin Farzaneh, Martin Pule
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 116-128 (2023)
γ-Retroviral vectors (γ-RV) are powerful tools for gene therapy applications. Current clinical vectors are produced from stable producer cell lines which require minimal further downstream processing, while purification schemes for γ-RV produced b
Externí odkaz:
https://doaj.org/article/c3cb671a0496433383c9625ae6699248
Autor:
Claire Roddie, Karamjeet Sandhu, Eleni Tholouli, Paul Shaughnessy, Pere Barba Suñol, Manuel Nuno Direito de Morais Guerreiro, Mehrdad Abedi, Michael Bishop, Jean Yared, Armin Ghobadi, Deborah Yallop, Aaron Logan, Beitinjaneh Amer, Jeremy Pantin, Martha L Arellano, Sridhar Chaganti, Ram Malladi, Tobias Menne, Virginia Escamilla, Katharine Hodby, Krishna Gundabolu, Luke Mountjoy, Kristen Odwyer, Sameem Abedin, Hassan Alkhateeb, Bijal Shah, Silvia Basilico, Deborah Cluxton, Joanna Dawes, Pierre Lao-Sirieix, Meera Raymond, Justin Shang, Yanqing Hu, Gianfranco Pittari, Kapil Saxena, Wolfram Brugger, Y Zhang, Martin Pule, Daniel Park, Daniel De Angelo, Elias Jabbour
Publikováno v:
HemaSphere, Vol 7, p e998506d (2023)
Externí odkaz:
https://doaj.org/article/847828f94a674a0c9263a5a47141ff67
Autor:
Simon Thomas, Julia Taylor, Manuel Rodriguez-Justo, Kwee Yong, Mathieu Ferrari, Shimobi Onuoha, Sonja Zweegman, Rakesh Popat, Lydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie Cerec, Shaun Cordoba, Nushmia Khokhar, Vijay Peddareddigari, Muhammad Al-Hajj, Jim Cavet, Martin Pule
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background We used a proliferating ligand (APRIL) to construct a ligand-based third generation chimeric antigen receptor (CAR) able to target two myeloma antigens, B-cell maturation antigen (BCMA) and transmembrane activator and CAML interactor.Metho
Externí odkaz:
https://doaj.org/article/8067650d1c374058a81e8dfb09c80620
Autor:
Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs and ITSMs on inhibitory immune receptors. Consequently, SHP1 and SHP2 are key proteins in the transmission of inhibitor
Externí odkaz:
https://doaj.org/article/e38d52e6c99944609c3459b7f08fd187
Autor:
James E Sillibourne, Giulia Agliardi, Matteo Righi, Katerina Smetanova, Grant Rowley, Simon Speller, Abigail Dolor, Katarina Lamb, Christopher Allen, Rajeev Karattil, Farhaan Parekh, Frederick Arce Vargas, Simon Thomas, Shaun Cordoba, Martin Pule
Publikováno v:
BioTechniques, Vol 72, Iss 4, Pp 143-154 (2022)
The development of multicistronic vectors enabling differential transgene expression is a goal of gene therapy and poses a significant engineering challenge. Current approaches rely on the insertion of long regulatory sequences that occupy valuable s
Externí odkaz:
https://doaj.org/article/378103da300e46c791933431ae4e6844
Autor:
Alastair Hotblack, Evangelia K. Kokalaki, Morgan J. Palton, Gordon Weng-Kit Cheung, Iwan P. Williams, Somayya Manzoor, Thomas I. Grothier, Alice Piapi, Valeria Fiaccadori, Patrycja Wawrzyniecka, Harriet A. Roddy, Giulia Agliardi, Claire Roddie, Shimobi Onuoha, Simon Thomas, Shaun Cordoba, Martin Pule
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular
Externí odkaz:
https://doaj.org/article/dee4a8da64cb4a34bd085ebded529484
Autor:
Leila Mekkaoui, Emma Bentley, Mathieu Ferrari, Katarina Lamb, Katarzyna Ward, Rajeev Karattil, Zulaikha Akbar, Reyisa Bughda, James Sillibourne, Shimobi Onuoha, Giada Mattiuzzo, Yasu Takeuchi, Martin Pule
Publikováno v:
Bio-Protocol, Vol 11, Iss 16 (2021)
The use of recombinant lentivirus pseudotyped with the coronavirus Spike protein of SARS-CoV-2 would circumvent the requirement of biosafety-level 3 (BSL-3) containment facilities for the handling of SARS-CoV-2 viruses. Herein, we describe a fast and
Externí odkaz:
https://doaj.org/article/562d7684ec5d4b66a9d08a16484d69e1