Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Martin Puhr"'
Autor:
Justus S. Israel, Laura-Maria Marcelin, Sherif Mehralivand, Jana Scholze, Jörg Hofmann, Matthias B. Stope, Martin Puhr, Christian Thomas, Holger H. H. Erb
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Introduction Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives tumour initiation and progression. Consequently, antagonising AR activity via anti-androgens is
Externí odkaz:
https://doaj.org/article/7393c3fec1f5417aa2839dba9436cbb5
Autor:
Justus Simon Israel, Laura-Maria Marcelin, Christian Thomas, Eva Szczyrbová, Susanne Fuessel, Martin Puhr, Johannes Linxweiler, Shivani Yalala, Wilbert T. Zwart, Aria Baniahmad, Jasper van Goubergen, Harri M. Itkonen, Adam Sharp, Edward O’Neill, Marc Pretze, Matthias Miederer, Holger H.H. Erb
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Continued exploration of the androgen receptor (AR) is crucial, as it plays pivotal roles in diverse diseases such as prostate cancer (PCa), serving as a significant therapeutic focus. Therefore, the Department of Urology Dresden hosted an i
Externí odkaz:
https://doaj.org/article/39e0ffdb610b4782878eda81fbb46bd2
Autor:
Sherif Mehralivand, Christian Thomas, Martin Puhr, Frank Claessens, Arjanneke F. van de Merbel, Anna Dubrovska, Guido Jenster, Christof Bernemann, Ulrich Sommer, Holger H. H. Erb
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-8 (2024)
Abstract The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linchpin of current PCa therapies. De
Externí odkaz:
https://doaj.org/article/2100acb6c028487ea1592470d98b2707
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Olesya Vakhrusheva, Holger H. H. Erb, Vitus Bräunig, Sascha D. Markowitsch, Patricia Schupp, Patrick C. Baer, Kimberly Sue Slade, Anita Thomas, Igor Tsaur, Martin Puhr, Zoran Culig, Jindrich Cinatl, Martin Michaelis, Thomas Efferth, Axel Haferkamp, Eva Juengel
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to exhibit tumor suppressive properties. Therefore, the therapeutic potential of artesunate (ART)
Externí odkaz:
https://doaj.org/article/e8bf3189c0f242e381ae779a1a745f9c
Autor:
Elisa Pardella, Erica Pranzini, Ilaria Nesi, Matteo Parri, Pietro Spatafora, Eugenio Torre, Angela Muccilli, Francesca Castiglione, Massimiliano Fambrini, Flavia Sorbi, Paolo Cirri, Anna Caselli, Martin Puhr, Helmut Klocker, Sergio Serni, Giovanni Raugei, Francesca Magherini, Maria Letizia Taddei
Publikováno v:
Cells, Vol 11, Iss 24, p 4026 (2022)
Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition of aggress
Externí odkaz:
https://doaj.org/article/328f75d594d349b1a118355d856c6e81
Autor:
Andreas Pircher, Martin Zieher, Andrea Eigentler, Renate Pichler, Georg Schäfer, Josef Fritz, Martin Puhr, Eberhard Steiner, Wolfgang Horninger, Helmut Klocker, Isabel Heidegger
Publikováno v:
Cancer Biology & Therapy, Vol 19, Iss 12, Pp 1153-1161 (2018)
Background: We investigated the role of diabetes mellitus (DM) and the molecular mechanisms of antidiabetic drugs in prostate cancer (PCa).Patients and Methods: 167 patients with both DM and PCa underwent radical prostatectomy (RPE). We divided our p
Externí odkaz:
https://doaj.org/article/6529ef5e40f3475b8a44262b907277d6
Autor:
Simone Meidhof, Simone Brabletz, Waltraut Lehmann, Bogdan‐Tiberius Preca, Kerstin Mock, Manuel Ruh, Julia Schüler, Maria Berthold, Anika Weber, Ulrike Burk, Michael Lübbert, Martin Puhr, Zoran Culig, Ulrich Wellner, Tobias Keck, Peter Bronsert, Simon Küsters, Ulrich T Hopt, Marc P Stemmler, Thomas Brabletz
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 6, Pp 831-847 (2015)
Abstract Therapy resistance is a major clinical problem in cancer medicine and crucial for disease relapse and progression. Therefore, the clinical need to overcome it, particularly for aggressive tumors such as pancreatic cancer, is very high. Aberr
Externí odkaz:
https://doaj.org/article/86d69cdad4a84da692d75fa5e3c574a3
Autor:
Hannes Neuwirt, Elisabeth Wabnig, Clemens Feistritzer, Iris E Eder, Christina Salvador, Martin Puhr, Zoran Culig, Petra Massoner, Martin Tiefenthaler, Michael Steurer, Guenther Konwalinka
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117806 (2015)
Akacid medical formulation (AMF) is an oligoguanidine that exerts biocidal activity against airborne and surface microorganisms including bacteria, viruses, fungi, and molds, while showing relatively low toxicity to humans. We have previously shown t
Externí odkaz:
https://doaj.org/article/16ae28c6ae26480c9b8884ba21951c0e
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 149:2259-2270
Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant modification of the tumour’s bioenergetics provides energy for tumour growth and progression. Otto Warburg first reported these metabolic and biochemical changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f3669b13cf01220143549f936937e9
https://doi.org/10.1007/s00432-022-04371-w
https://doi.org/10.1007/s00432-022-04371-w