Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Martin Pook"'
Autor:
Mai Abdel Mouti, Siwei Deng, Martin Pook, Jessica Malzahn, Aniko Rendek, Stefania Militi, Reshma Nibhani, Zahir Soonawalla, Udo Oppermann, Chang-il Hwang, Siim Pauklin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Pancreatic cancer (PC), one of the most aggressive and life-threatening human malignancies, is known for its resistance to cytotoxic therapies. This is increasingly ascribed to the subpopulation of undifferentiated cells, known as pancreatic
Externí odkaz:
https://doaj.org/article/e03882910170417599161aa3b318306e
Autor:
Kapilraj Periyasamy, Maria Maloverjan, Abhijit Biswas, Anu Remm, Martin Pook, Ana Rebane, Margus Pooga
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
mRNA-based vaccines and candidate therapeutics have great potential in various medical fields. For the delivery of mRNA into target cells and tissues, lipid formulations are often employed. However, this approach could cause the activation of immune
Externí odkaz:
https://doaj.org/article/c7f7dcd1de354dcd9c5404eec0e10733
Autor:
Keerthana Chithanathan, Monika Jürgenson, Mithu Guha, Ling Yan, Tamara Žarkovskaja, Martin Pook, Nathaniel Magilnick, Mark P. Boldin, Ana Rebane, Li Tian, Alexander Zharkovsky
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b (miR-146a/b), both of which are known to suppress immune responses in a variety of conditions. Here, we studied how constitutive deficiency of miR-146b (Mir146b-/-) affects
Externí odkaz:
https://doaj.org/article/28cdd8f7d6cb4b09bc5d34cb564b556a
Autor:
Egle-Helene Ervin, Martin Pook, Indrek Teino, Valmar Kasuk, Annika Trei, Margus Pooga, Toivo Maimets
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On the other hand, RNA int
Externí odkaz:
https://doaj.org/article/50205bb260684d2cbb3e422b4eefcc20
Autor:
Ljudmila Klepinina, Aleksandr Klepinin, Laura Truu, Vladimir Chekulayev, Heiki Vija, Kaisa Kuus, Indrek Teino, Martin Pook, Toivo Maimets, Tuuli Kaambre
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245348 (2021)
The ability of butyrate to promote differentiation of cancer cells has important implication for colorectal cancer (CRC) prevention and therapy. In this study, we examined the effect of sodium butyrate (NaBT) on the energy metabolism of colon adenoca
Externí odkaz:
https://doaj.org/article/4bdc7c2e72e34189ac95531ad5bdfcc0
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138346 (2015)
Laminin isoforms laminin-511 and -521 are expressed by human embryonic stem cells (hESC) and can be used as a growth matrix to culture these cells under pluripotent conditions. However, the expression of these laminins during the induction of hESC di
Externí odkaz:
https://doaj.org/article/c95b2c9357f64e6a9002648ef8ce9930
Publikováno v:
Stem Cells International, Vol 2014 (2014)
Transcription factors NANOG, OCT4, and SOX2 regulate self-renewal and pluripotency in human embryonic stem (hES) cells; however, their expression profiles during early differentiation of hES cells are unclear. In this study, we used multiparameter fl
Externí odkaz:
https://doaj.org/article/9ab50573cdac458b91086b7a178258d1
Publikováno v:
International Journal of Cell Biology, Vol 2014 (2014)
As cyclin-dependent kinases (CDKs) regulate cell cycle progression and RNA transcription, CDKs are attractive targets for creating cancer cell treatments. In this study we investigated the effects of the small molecular agent NU6140 (inhibits CDK2 an
Externí odkaz:
https://doaj.org/article/0e5362c80e754ff2ab7b495fe0d68bd1
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19114 (2011)
Nocodazole is a known destabiliser of microtubule dynamics and arrests cell-cycle at the G2/M phase. In the context of the human embryonic stem cell (hESC) it is important to understand how this arrest influences the pluripotency of cells. Here we re
Externí odkaz:
https://doaj.org/article/a2a656c8cc444fa7b5564323ff06d380
Autor:
Arnold Kristjuhan, Helen Vaher, Annika Trei, Inge Varik, Tõnis Org, Laura Pajusaar, Toivo Maimets, Indrek Teino, Antti Matvere, Martin Pook, Keyt Uudeküll
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9052, p 9052 (2020)
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9052, p 9052 (2020)
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which mediates the effects of a variety of environmental stimuli in multiple tissues. Recent advances in AHR biology have underlined its importance in cells with high develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33c6e3c038ace6e50be91b91ba5af1d
http://europepmc.org/articles/PMC7731104
http://europepmc.org/articles/PMC7731104