Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Martin Poirier"'
Autor:
David F Fischer, Sipke Dijkstra, Kimberly Lo, Johnny Suijker, Ana C P Correia, Patricia Naud, Martin Poirier, Michela A Tessari, Ivette Boogaard, Geraldine Flynn, Mijke Visser, Marieke B A C Lamers, George McAllister, Ignacio Munoz-Sanjuan, Douglas Macdonald
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266812 (2022)
Huntington's disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant huntingtin protein (mHTT) containing an expanded polyglutamine tract in the amino terminus. A num
Externí odkaz:
https://doaj.org/article/d40329dcbdbd4ce6b214f506ecdfe85c
Autor:
Mark Wissel, Martin Poirier, Christina Satterwhite, John Lin, Rafiq Islam, Jennifer Zimmer, Ardeshir Khadang, Jennifer Zemo, Todd Lester, Marianne Fjording, Amanda Hays, Nicola Hughes, Fabio Garofolo, Rudolf Guilbaud, Elizabeth Groeber, Heidi Renfrew, Kelly Colletti, Mathilde Yu, Jenny Lin, Xinping Fang, Santosh Shah, Wei Garofolo, Sumit Kar, Roger Hayes, John Pirro, Cheikh Kane, Marsha Luna, Allan Xu, Stephanie Cape, Mark O'Dell, Robert Wheller, Hanna Ritzen, Jennifer Vance, Esme Farley, Katie Matys, Edward Tabler, William Mylott, Moucun Yuan, Shane Karnik, Troy Voelker, Ira DuBey, Clark Williard, Jing Shi, Jim Yamashita
Publikováno v:
Bioanalysis. 14(12)
Gene therapy, cell therapy and vaccine research have led to an increased use of qPCR/ddPCR in bioanalytical laboratories. CROs are progressively undertaking the development and validation of qPCR and ddPCR assays. Currently, however, there is limited
Autor:
Rafiq Islam, Jennifer Vance, Martin Poirier, Jennifer Zimmer, Ardeshir Khadang, Dave Williams, Jennifer Zemo, Todd Lester, Marianne Fjording, Amanda Hays, Nicola Hughes, Fabio Garofolo, Curtis Sheldon, Rudolf Guilbaud, Christina Satterwhite, Kelly Colletti, Elizabeth Groeber, Heidi Renfrew, Mathilde Yu, Jenny Lin, Xinping Fang, Mark Wissel, Thomas Beadnell, John Lin, Santosh Shah, Wei Garofolo, Natasha Savoie, Roger Hayes, John Pirro, Cheikh Kane, Marsha Luna, Allan Xu, Stephanie Cape, Mark O'Dell, Robert Wheller, Hanna Ritzen, Esme Farley, Lisa Kierstead, William Mylott, Edward Tabler, Moucun Yuan, Shane Karnik, Troy Voelker, Ira DuBey, Clark Williard, Kelly Dong, Jing Shi, Jim Yamashita
Publikováno v:
Bioanalysis. 14(4)
Gene therapy, cell therapy and vaccine research have led to an increased need to perform cellular immunity testing in a regulated environment to ensure the safety and efficacy of these treatments. The most common method for the measurement of cellula
Autor:
Rohit Srikonda, Kjetil Abelsen, Martin Poirier, Martin Karlstad, Curt Kling, Massimiliano Russo
Publikováno v:
Volume 3: Structures, Safety, and Reliability.
The operating boundaries and associated watch circles of an offshore drilling campaign are traditionally assessed by technical analysis including simulations of rig, riser and conductor/casing response to determine the mechanical limits and confirm t
Autor:
Martin Poirier
Publikováno v:
Documentation et bibliothèques. 44:79-91
Cet article relate la mise en place, pour le département Recherche et Développement de l’Institut de Recherche et Coordination Acoustique/Musique (IRCAM) à Paris, d’une base de notices bibliographiques d’articles scientifiques sur la musique
Autor:
Marc-André Poupart, James Gillard, Pierre L. Beaulieu, George Kukolj, Sylvie Goulet, Martin Poirier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:196-200
Previously described SAR of benzimidazole-based non-nucleoside finger loop (Thumb Pocket I) inhibitors of HCV NS5B polymerase was expanded. Prospecting studies using parallel synthesis techniques allowed the rapid identification of novel cinnamic aci
Publikováno v:
Journal of Immunotoxicology. 3:157-164
The human monoclonal antibody CP-870,893 is a CD40 receptor agonist currently being developed for the treatment of cancer. A bioassay to measure neutralizing antibodies (Nab) to CP-870,893 in 5% human serum matrix was developed and validated utilizin
Autor:
Vida Gorys, Youla S. Tsantrizos, Christian Brochu, Anne-Marie Faucher, Jean-Marie Ferland, Pierre L. Beaulieu, Ted Halmos, Stephen H. Kawai, Martin Poirier, Jean-Simon Duceppe, Murray D. Bailey, Ghiro Elise, Montse Llinas-Brunet, Bruno Simoneau
Publikováno v:
Organic Letters. 6:2901-2904
The synthesis of BILN 2061, an NS3 protease inhibitor with proven antiviral effect in humans, was accomplished in a convergent manner from four building blocks. The procedure described here was suitable for the preparation of multigram quantities of
Autor:
Marc-André Poupart, Ghiro Elise, Youla S. Tsantrizos, Nathalie Goudreau, Catherine Chabot, Dale R. Cameron, Sylvie Goulet, Martin Poirier
Publikováno v:
The Journal of Organic Chemistry. 66:4743-4751
The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been
Autor:
Dominik Wernic, Gulrez Fazal, Vida Gorys, Montse Llinas-Brunet, Ghiro Elise, Diane Thibeault, Marc-André Poupart, Jean Rancourt, Murray D. Bailey, Daniel Lamarre, Ted Halmos, Roger Maurice, Martin Poirier, Sylvie Goulet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2267-2270
Structure-activity studies on a hexapeptide N-terminal cleavage product of a dodecamer substrate led to the identification of very potent and highly specific inhibitors of the HCV NS3 protease/NS4A cofactor peptide complex. The largest increase in po