Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Martin Picard"'
Autor:
Matthew C. L. Phillips, Martin Picard
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2024)
Abstract Neurodegenerative disorders are typically “split” based on their hallmark clinical, anatomical, and pathological features, but they can also be “lumped” by a shared feature of impaired mitochondrial biology. This leads us to present
Externí odkaz:
https://doaj.org/article/975a5dad0c274bd5b2465f336718f6ca
Autor:
Weichen Zhou, Kalpita R Karan, Wenjin Gu, Hans-Ulrich Klein, Gabriel Sturm, Philip L De Jager, David A Bennett, Michio Hirano, Martin Picard, Ryan E Mills
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002723 (2024)
The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has been linked to lifespan in nonhuman species and recently demonstrated to occur in rare instances from one human generation to the next. Here, we investigated numtoge
Externí odkaz:
https://doaj.org/article/eea7e63066f54cc38b1e1e976ca6657e
Autor:
Vladimir Adrien, Myriam Reffay, Nicolas Taulier, Alice Verchère, Laura Monlezun, Martin Picard, Arnaud Ducruix, Isabelle Broutin, Frédéric Pincet, Wladimir Urbach
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Molecular interactions are contingent upon the system’s dimensionality. Notably, comprehending the impact of dimensionality on protein–protein interactions holds paramount importance in foreseeing protein behaviour across diverse scenari
Externí odkaz:
https://doaj.org/article/dcc1cdc4396d456b8e500a4c65e83c99
Autor:
Ayelet M. Rosenberg, Manish Saggar, Anna S. Monzel, Jack Devine, Peter Rogu, Aaron Limoges, Alex Junker, Carmen Sandi, Eugene V. Mosharov, Dani Dumitriu, Christoph Anacker, Martin Picard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied at a brain-wide scale. Here we examined the
Externí odkaz:
https://doaj.org/article/941e18427e5a4b75b3dce7e14eca5d2e
Autor:
Vladimir Adrien, Myriam Reffay, Nicolas Taulier, Alice Verchère, Laura Monlezun, Martin Picard, Arnaud Ducruix, Isabelle Broutin, Frédéric Pincet, Wladimir Urbach
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/3883ba256a5845b981367485f1d10152
Autor:
Gabriel Sturm, Kalpita R. Karan, Anna S. Monzel, Balaji Santhanam, Tanja Taivassalo, Céline Bris, Sarah A. Ware, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J. McManus, Andres Cardenas, Jue Lin, Elissa S. Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G. Haller, Guy Lenaers, Douglas C. Wallace, Marie-Pierre St-Onge, Saeed Tavazoie, Vincent Procaccio, Brett A. Kaufman, Erin L. Seifert, Michio Hirano, Martin Picard
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-22 (2023)
A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a ce
Externí odkaz:
https://doaj.org/article/8f3a6949c7834f1f9cf472f8feac04b2
Autor:
Gabriel Sturm, Anna S. Monzel, Kalpita R. Karan, Jeremy Michelson, Sarah A. Ware, Andres Cardenas, Jue Lin, Céline Bris, Balaji Santhanam, Michael P. Murphy, Morgan E. Levine, Steve Horvath, Daniel W. Belsky, Shuang Wang, Vincent Procaccio, Brett A. Kaufman, Michio Hirano, Martin Picard
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-19 (2022)
Measurement(s) gene expression assay • DNA Methylation • Telomere Length • Seahorse Bioenergetics • mtDNA copy number • Whole Genome Sequencing • Cytokine • cell-free DNA • mtDNA sequencing • cell-free GDF15 • cell-free IL6 Techno
Externí odkaz:
https://doaj.org/article/d6a7639344dc491583d7e15621e35c15
Autor:
Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett, Philip L. De Jager
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Abstract Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden have both been asso
Externí odkaz:
https://doaj.org/article/838182d8c8224a2495fb01b890d7243e
Autor:
Johan Fernström, Synthia H. Mellon, Marlon A. McGill, Martin Picard, Victor I. Reus, Christina M. Hough, Jue Lin, Elissa S. Epel, Owen M. Wolkowitz, Daniel Lindqvist
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic activity—the Mitochondrial Health Index (MHI)—has previously been found to correlate with stres
Externí odkaz:
https://doaj.org/article/bb5e5046f7e5489088c9d6125ed82ea3
Autor:
Richard F Oppong, Antonio Terracciano, Martin Picard, Yong Qian, Thomas J Butler, Toshiko Tanaka, Ann Zenobia Moore, Eleanor M Simonsick, Krista Opsahl-Ong, Christopher Coletta, Angelina R Sutin, Myriam Gorospe, Susan M Resnick, Francesco Cucca, Sonja W Scholz, Bryan J Traynor, David Schlessinger, Luigi Ferrucci, Jun Ding
Publikováno v:
eLife, Vol 11 (2022)
Background: Mitochondrial DNA copy number (mtDNAcn) in tissues and blood can be altered in conditions like diabetes and major depression and may play a role in aging and longevity. However, little is known about the association between mtDNAcn and pe
Externí odkaz:
https://doaj.org/article/64ebb18f36834dd8a52e9975164dd757