In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis

Autor: Sapna Desai, Danuta Ewa Irena Mossakowska, Scott P. Webster, Duncan S. Holmes, Andrew McBride, Jonathan A. Fallowfield, Kate Simpson, Martin P. Ruediger, Mark J. Bamford, Rebecca L. Aucott, Jeremy Griggs, John P. Iredale, Ivan Caballero-Hernandez, Anna M. Hoy, Theresa J. Pell

Publikováno v: McBride, A, Hoy, A M, Bamford, M J, Mossakowska, D E, Ruediger, M P, Griggs, J, Desai, S, Simpson, K, Caballero-Hernandez, I, Iredale, J P, Pell, T, Aucott, R L, Holmes, D S, Webster, S P & Fallowfield, J A 2017, ' In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis ', Scientific Reports, vol. 7, no. 1, pp. 10806 . https://doi.org/10.1038/s41598-017-10521-9
Scientific Reports
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

The peptide hormone human relaxin-2 (H2-RLX) has emerged as a potential therapy for cardiovascular and fibrotic diseases, but its short in vivo half-life is an obstacle to long-term administration. The discovery of ML290 demonstrated that it is possi

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https://doi.org/10.1038/s41598-017-10521-9