Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Martin P. Maguire"'
Autor:
Asher Zilberstein, Allison L. Zulli, Alfred P. Spada, Persons Paul E, Daniel L. Cheney, Myers Michael R, Karen J. Mitchell, Carol Franks, Susan E. Johnson, Natalie N. Setzer, Cuong Ly, Martin P. Maguire
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:421-424
We have identified moderately potent and selective inhibitors of CSF-1R tyrosine kinase activity.1 A preliminary SAR study resulted in the identification of compounds 11 and 20 as the most potent analogues in the series (IC50 = 0.18 μM). The 3-D-con
Publikováno v:
Journal of Medicinal Chemistry. 37:2129-2137
A series of 63 3-substituted quinoline derivatives has been prepared and tested for inhibition of cell-free platelet derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The compounds were generally prepared either by a Friedlander con
Publikováno v:
The Journal of Organic Chemistry. 59:4186-4193
The nucleosides S-adenosylmethionine (SAM, AdoMet) and S-adenosylhomocysteine (SAH, AdoHcy) are involved in a number of important enzyme systems. The direct or indirect inhibition of these enzymes is currently of high interest, particularly in the ar
Publikováno v:
ChemInform. 25
A series of 63 3-substituted quinoline derivatives has been prepared and tested for inhibition of cell-free platelet derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The compounds were generally prepared either by a Friedlander con
Autor:
Carol Franks, Asher Zilberstein, Myers Michael R, Martin P. Maguire, Persons Paul E, Alfred P. Spada, Allison L. Zulli, K. J. Mitchell, Susan E. Johnson, Natalie N. Setzer, Cuong Ly, Daniel L. Cheney
Publikováno v:
ChemInform. 28
Publikováno v:
Biochemical Pharmacology. 43:2471-2477
The inhibition mechanisms of the epidermal growth factor (EGF) receptor tyrosine kinase and the cAMP-dependent kinase activities by erbstatin and its analogue, RG 14921, were studied by kinetic analysis. Both compounds were slow-binding inhibitors of
Publikováno v:
The Journal of Organic Chemistry. 55:948-955
Synthese de l'antibiotique du titre a partir du D-ribose, du L-ormithine, et de l'adenine. Determination de la stereochimie de la partie pyrrolidine par rayon X
Autor:
Suresh K. Balani, Tricia J. Vos, Jennifer Lee Che, Martin P. Maguire, Ping Li, Luis E Rodriguez, Cheryl A. Farrer, Michael A. Patane, Christopher F. Claiborne, Stacey V Drabic, Andrei Caracoti, David Yowe, Nancy E. Forsyth, Diana Lamppu, Ingrid B J K Joseph, Hang Zeng, Robert A. Horlick, Mingshi Dai
Publikováno v:
Journal of medicinal chemistry. 47(7)
The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body
Autor:
Glenda Bilder, Natalie Setzer, Barbara Hanney, Helen Galzcinski, Myers Michael, Spada Alfred P, Saul Needle, Dilip Amin, Wei He, Martin P. Maguire, Allison L Zulli
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
Novel substituted 2-anilino- and 2-cycloalkylaminoquinoxalines have been found to be useful and selective inhibitors of PDGF-R autophosphorylation. Replacement of an anilino-substituent with substituted cyclohexylamino- or norbornylamino substituents
Autor:
T. Ross Kelly, Martin P. Maguire
Publikováno v:
Tetrahedron. 41:3033-3036
A five-step synthesis of the unusual marine alkaloid aaptamine ( 1 ) from veratrole is described (Scheme 1).