Výsledky vyhledávání - "Martin P Vidgeon-Hart"

Akademický článek

Perturbation of microRNAs in rat heart during chronic doxorubicin treatment.

Autor: Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40395 (2012)

Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff

Externí odkaz: https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0

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Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury

Autor: Ann M. Williams, Martin P. Vidgeon-Hart, Christopher A. Schofield, Metul Patel, Paul McGill, Carla F. Newman, Justyna M. Macina, Tracy Walker, Maxine A. Taylor, Melanie Z. Sakatis, Denise F. Vlachou

Publikováno v: Chemical Research in Toxicology. 34:2485-2499

Drug-induced liver injury is a leading cause of compound attrition during both preclinical and clinical drug development, and early strategies are in place to tackle this recurring problem. Human-relevant in vitro models that are more predictive of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d28a0d1ea9b48ae863da568dd1fc180
https://doi.org/10.1021/acs.chemrestox.1c00227

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Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment

Autor: Kelly M Gatfield, Miyoung Park, Il-Hong Bae, Martin P. Vidgeon-Hart, Gyeyoung Choi, Jin Kyu Choi, Chang Seok Lee, Angie Burns, Young-Ho Park, Rajni Fagg, Andrew J. Powell, Anita A. Naidoo

Publikováno v: Cell biology and toxicology. 34(2)

A recent hypothesis suggesting that the pharmacological target TRPV1 (transient receptor potential vanilloid subfamily, member 1) may function as a tumour suppressor, which potentially impacts the development of TRPV1 antagonist therapeutics for a ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ff9d90ca0af30b71395d215fae3db8
https://pubmed.ncbi.nlm.nih.gov/28815372

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The PPARγ agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B

Autor: Neil Upton, David Virley, Helen Chapman, Martin P. Vidgeon-Hart, Andrew D. Medhurst, Leann P. Quinn, M E Hows, Barry Crook

Publikováno v: British Journal of Pharmacology. 154:226-233

Background and purpose: The peroxisome proliferator-activated receptor-g (PPARg) agonist pioglitazone has previously been shown to attenuate dopaminergic cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59ade69cd1baf2af10434e18a932ba47
https://doi.org/10.1038/bjp.2008.78

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A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: Pharmacological validation with R-(−)-deprenyl

Autor: Neil Upton, Peter L. Woodhams, Helen Chapman, Martin P. Vidgeon-Hart, Marion J. Perren, Menelas N. Pangalos, Leann P. Quinn, David Virley, Kim Brackenborough

Publikováno v: Journal of Neuroscience Methods. 164:43-49

A beam-walking apparatus has been evaluated for its ability to detect motor impairments in mice acutely treated with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg, s.c., single or double administration). Mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317bc4e7bf001e7cdcbd8e710e80aaff
https://doi.org/10.1016/j.jneumeth.2007.03.021

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Hypercholesterolaemia and circulating levels of CXC chemokines in apoE*3 Leiden mice

Autor: David C. Grimsditch, Philip Overend, Annette Graham, Suzanne Parkin, Pieter H.E. Groot, G. Martin Benson, Martin P. Vidgeon-Hart, Nuala Murphy

Publikováno v: Atherosclerosis. 163:69-77

Hyperlipidaemia may accelerate the development of atherosclerosis by enhancing the expression of chemokines by cells within the arterial wall. Chemokines of the CC subfamily are clearly implicated in atherogenesis; however, recent reports suggest tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf73216e0f0454d283a1ab0884b0d98
https://doi.org/10.1016/s0021-9150(01)00755-9

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Perturbation of microRNAs in Rat Heart during Chronic Doxorubicin Treatment

Autor: Brian R. Berridge, Yasmina Bauer, Martin Letzkus, Philippe Couttet, Caterina Vacchi-Suzzi, Kevin Gerrish, Jonathan J. Lyon, Sandrine Bongiovanni, Francois Pognan, Olivier Grenet, Martin P. Vidgeon-Hart, Richard S. Paules, Frank Staedtler, Jonathan G. Moggs, Hisham K. Hamadeh

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91657dbcaff190b76c47698e687a601c
http://europepmc.org/articles/PMC3409211

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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Autor: Neil Upton, Simon T. Bate, Marion J. Perren, Flora Joyce, Jill C. Richardson, Tracey Ashmeade, Ainsley A. Culbert, David Virley, David Sunter, Zoe Seymour, Martin P. Vidgeon-Hart, Anna Babin, Perdita L. Pugh

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 4, Iss 1, p 8 (2007)

Background Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d23f497a6835ad219a7d2a9664abc1
https://pubmed.ncbi.nlm.nih.gov/17324270

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