Zobrazeno 1 - 10 of 145 pro vyhledávání: '"Martin P Barr"'
3
Akademický článek
Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells.
Autor: Magdalena Circu, James Cardelli, Martin P Barr, Kenneth O'Byrne, Glenn Mills, Hazem El-Osta
Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184922 (2017)
Lung cancer is the leading cause of cancer-related deaths. Most patients develop resistance to platinum within several months of treatment. We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can rest
Externí odkaz: https://doaj.org/article/4991f40102d04804a67760c369a679f2
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4
Akademický článek
Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature.
Autor: Martin P Barr, Steven G Gray, Andreas C Hoffmann, Ralf A Hilger, Juergen Thomale, John D O'Flaherty, Dean A Fennell, Derek Richard, John J O'Leary, Kenneth J O'Byrne
Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54193 (2013)
IntroductionInherent and acquired cisplatin resistance reduces the effectiveness of this agent in the management of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms underlying this process may result in the development of no
Externí odkaz: https://doaj.org/article/18af4cd6dbdb4d73aa78e1b2488d6a3e
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5
Akademický článek
Genomic Landscape of NSCLC in the Republic of Ireland
Autor: Rachel J. Keogh, MB BCH BAO, Martin P. Barr, PhD, Anna Keogh, MB BCH BAO, David McMahon, MB BCH BAO, Cathal O’Brien, PhD, Stephen P. Finn, MD, Jarushka Naidoo, MBBCH, MHS
Publikováno v: JTO Clinical and Research Reports, Vol 5, Iss 2, Pp 100627- (2024)
Introduction: The identification of genomic “targets” through next-generation sequencing (NGS) of patient’s NSCLC tumors has resulted in a rapid expansion of targeted treatment options for selected patients. This retrospective study aims to ide
Externí odkaz: https://doaj.org/article/7485f09829ab430c9cdf25af69656df9
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6
Akademický článek
Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation
Autor: Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng, Haozhe Piao
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-17 (2018)
Abstract Background Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain protein Ajuba regulates β-catenin and YAP signaling and is
Externí odkaz: https://doaj.org/article/02f78c6471d44c7aba6c7327a036c477
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7
Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses
Autor: Eimear Mylod, Ellen Mckenna, Maria Davern, Martin P Barr, Noel E Donlon, Becky AS Bibby, Anshul Bhardwaj, John V Reynolds, Joanne Lysaght, Stephen G. Maher, Melissa J. Conroy
Publikováno v: Clinical and Experimental Medicine. 23:411-425
Introduction: The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study investigated the su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719b0d3baec4e9a4cb3c837601267483
https://doi.org/10.1007/s10238-022-00811-6
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9
The DNA damage repair-related gene PKMYT1 is a potential biomarker in various malignancies
Autor: Changjian Shao, Yuanyong Wang, Minghong Pan, Kai Guo, Tamas F. Molnar, Florian Kocher, Andreas Seeber, Martin P. Barr, Alfons Navarro, Jing Han, Zhiqiang Ma, Xiaolong Yan
Publikováno v: Transl Lung Cancer Res
BACKGROUND: Protein kinase membrane associated tyrosine/threonine 1 (PKMYT1) regulates cell cycle and is a part of DNA damage repair (DDR)-related signaling. Recent studies have identified a role for PKMYT1 in tumor immunity and DDR. Thus, we initiat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9658bfcc9d77a90d0721daf616762e2c
https://doi.org/10.21037/tlcr-21-973
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10
Liquid biopsy: a multi-parametric analysis of mutation status, circulating tumor cells and inflammatory markers in EGFR-mutated NSCLC
Autor: Martin P. Barr, Anne-Marie Baird, Sophia Halliday, Petra Martin, Emma H. Allott, James Phelan, Greg Korpanty, Linda Coate, Cathal O’Brien, Steven G. Gray, Jane S. Y. Sui, Brian Hayes, Sinead Cuffe, Stephen P. Finn
Publikováno v: Barr, M P, Baird, A-M, Halliday, S, Martin, P, Allott, E H, Phelan, J, Korpanty, G, Coate, L, O'Brien, C, Gray, S G, Sui, J S Y, Hayes, B, Cuffe, S & Finn, S P 2022, ' Liquid biopsy: a multi-parametric analysis of mutation status, circulating tumor cells and inflammatory markers in EGFR-mutated NSCLC ', Diagnostics, vol. 12, no. 10, 2360 . https://doi.org/10.3390/diagnostics12102360
Diagnostics; Volume 12; Issue 10; Pages: 2360
The liquid biopsy has the potential to improve patient care in the diagnostic and therapeutic setting in non-small cell lung cancer (NSCLC). Consented patients with epidermal growth factor receptor ( EGFR) positive disease ( n = 21) were stratified i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5666c2c821a71a85fa75536444dde520
https://pure.qub.ac.uk/en/publications/36bc6cdb-61bc-407d-b7f9-a0fd0e6af6e9
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