Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Martin Ott"'
Autor:
Verena Kohler, Andreas Kohler, Lisa Larsson Berglund, Xinxin Hao, Sarah Gersing, Axel Imhof, Thomas Nyström, Johanna L. Höög, Martin Ott, Claes Andréasson, Sabrina Büttner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality control compartment that handles misfolded proteins produced by the cytosolic pro
Externí odkaz:
https://doaj.org/article/5dbf4037911449959b5703bfa8fbcbd3
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionPatients who should benefit from anti-amyloid therapies (AAT) are found across all geriatric settings. Yet, it remains unclear how the use of AAT in patients with geriatric syndromes, such as frailty and polypharmacy, has so far been disc
Externí odkaz:
https://doaj.org/article/4e43a1831bb6412c9719e64dd9b61abf
Autor:
Jutta Diessl, Jens Berndtsson, Filomena Broeskamp, Lukas Habernig, Verena Kohler, Carmela Vazquez-Calvo, Arpita Nandy, Carlotta Peselj, Sofia Drobysheva, Ludovic Pelosi, F.-Nora Vögtle, Fabien Pierrel, Martin Ott, Sabrina Büttner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis
Externí odkaz:
https://doaj.org/article/4dc9625ee56c416c8681a2d756ae7db0
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The pyruvate dehydrogenase complex (PDHc) is a large multienzyme complex that converts pyruvate into acetyl-coenzyme A and in E. coli the core of the PDHc is formed by 24 copies of dihydrolipoyl transacetylase. Here, the authors present the cryo-EM s
Externí odkaz:
https://doaj.org/article/3ce4dfc9c80943b38a2d9c01e7957c65
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101359- (2022)
Summary: Many aspects of mitochondrial gene expression are still unknown, which can be attributed to limitations in molecular tools. Here, we present a protocol to introduce reporter genes into the mitochondrial genome of budding yeast, Saccharomyces
Externí odkaz:
https://doaj.org/article/0838ec9d3c194f8ca4a120d0661c083d
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100219- (2020)
Summary: Proximity-dependent biotin identification (BioID) permits biotinylation of proteins interacting directly, indirectly, or just localized in proximity of a protein of interest (bait). Here, we describe how BioID coupled to proteomics and netwo
Externí odkaz:
https://doaj.org/article/5178227096074d2491dc6f6be8c0def4
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
The mitochondrial respiratory chain is assembled into supercomplexes. Previously, two respiratory supercomplex-associated proteins, Rcf1 and Rcf2, were identified in Saccharomyces cerevisiae, which were initially suggested to mediate supercomplex for
Externí odkaz:
https://doaj.org/article/62c6c06f1d8b45cda2f5113bcd02d94a
Autor:
Tamara Suhm, Lukas Habernig, Magdalena Rzepka, Jayasankar Mohanakrishnan Kaimal, Claes Andréasson, Sabrina Buettner, Martin Ott
Publikováno v:
Microbial Cell, Vol 5, Iss 3, Pp 158-164 (2018)
The mitochondrial genome is responsible for the production of a handful of polypeptides that are core subunits of the membrane-bound oxidative phosphorylation system. Until now the mechanistic studies of mitochondrial protein synthesis inside cells h
Externí odkaz:
https://doaj.org/article/edadacf5656247bbaefb62b1027d7ff6
Autor:
Kirsten Kehrein, Ramon Schilling, Braulio Vargas Möller-Hergt, Christian A. Wurm, Stefan Jakobs, Tobias Lamkemeyer, Thomas Langer, Martin Ott
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 843-853 (2015)
Mitochondria contain their own genetic system that provides subunits of the complexes driving oxidative phosphorylation. A quarter of the mitochondrial proteome participates in gene expression, but how all these factors are orchestrated and spatially
Externí odkaz:
https://doaj.org/article/07c9ab385620431ea2f55dc32b24fb0d
Publikováno v:
Cells, Vol 7, Iss 10, p 172 (2018)
The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either synthesized in the cytosol and imported into the different compartments of the organelle or directly produced in the mitochondrial matrix. To ensure
Externí odkaz:
https://doaj.org/article/7039cf0574cb4134bea097212d7940a7