Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Martin Ondrej"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3971 (2020)
Mass spectrometry (MS) is a powerful and sensitive method often used for the identification of phosphoproteins. However, in phosphoproteomics, there is an identified need to compensate for the low abundance, insufficient ionization, and suppression e
Externí odkaz:
https://doaj.org/article/6c3d379fd6d2442986699e3550b86d98
Autor:
Barbora Šalovská, Hana Janečková, Ivo Fabrik, Radana Karlíková, Lucie Čecháková, Martin Ondrej, Marek Link, David Friedecký, Aleš Tichý
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199349 (2018)
Current anti-cancer strategy takes advantage of tumour specific abnormalities in DNA damage response to radio- or chemo-therapy. Inhibition of the ATR/Chk1 pathway has been shown to be synthetically lethal in cells with high levels of oncogene-induce
Externí odkaz:
https://doaj.org/article/b33611cc1f7e4cc3ba499710b069781a
Publikováno v:
Experimental Dermatology. 31:442-458
Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide
Publikováno v:
Cancer Genomics Proteomics
Background Autophagy is a crucial factor contributing to radioresistance during radiotherapy. Although Lys05 has proven its ability to improve the results of radiotherapy through the inhibition of autophagy, molecular mechanisms of this inhibition re
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 3971, p 3971 (2020)
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 3971, p 3971 (2020)
Mass spectrometry (MS) is a powerful and sensitive method often used for the identification of phosphoproteins. However, in phosphoproteomics, there is an identified need to compensate for the low abundance, insufficient ionization, and suppression e
Autor:
Vojtech Pavlik, Martin Ondrej, Ravi K. Amaravadi, Petr Jost, Dana Cizkova, Jaroslav Pejchal, Ales Bezrouk, Ales Tichy, Jeffrey D. Winkler, Lucie Cechakova
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 23
Volume 20
Issue 23
Autophagy inhibition through small-molecule inhibitors is one of the approaches to increase the efficiency of radiotherapy in oncological patients. A new inhibitor&mdash
Lys05&mdash
with the potential to accumulate within lysosomes and to b
Lys05&mdash
with the potential to accumulate within lysosomes and to b
Autor:
Kamila Ďurišová, Zuzana Šinkorová, Jiřina Vávrová, Petr Jost, Lucie Cechakova, Aleš Tichý, Jaroslav Pejchal, Martin Ondrej, Adela Kmochova
Publikováno v:
Journal of Applied Biomedicine. 16:66-74
The aim of this study was to compare the effects of DNA repair inhibitors in the context of radio-sensitization of human lung cells. The radio-sensitizing effects of NU7441 (1 mM), an inhibitor of DNA-dependent protein kinase (DNA-PK); KU55933 (10 μ
Autor:
Aleš Tichý, Ivo Fabrik, Marek Link, Radana Karlíková, Hana Janečková, Martin Ondrej, Barbora Salovska, Lucie Cechakova, David Friedecký
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199349 (2018)
PLoS ONE, Vol 13, Iss 7, p e0199349 (2018)
Current anti-cancer strategy takes advantage of tumour specific abnormalities in DNA damage response to radio- or chemo-therapy. Inhibition of the ATR/Chk1 pathway has been shown to be synthetically lethal in cells with high levels of oncogene-induce
Autor:
Klara Kubelkova, Kamila Durisova, Marketa Nemcova, Jaroslav Pejchal, Martin Ondrej, Jan Bures, Adela Kmochova, Ilja Tachecí, Ales Tichy, Anna Lierová, Sarka Pruchova, Kamil Kuca, Zuzana Šinkorová, Ilona Fatorova, Jirina Vavrova, Lucie Cechakova
Publikováno v:
Radiation research. 186(3)
We examined the effect of epidermal growth factor (EGF) treatment in mice that received bone marrow transplantation (BMT) after 11 Gy whole-body irradiation. C57Bl/6 mice were divided into three treatment groups: 0 Gy; 11 Gy ((60)Co, single dose, 0.5
Publikováno v:
Radiotherapy and Oncology. (2):265-275
Radiation-induced autophagy is believed to represent a radioprotective mechanism of cancer cells. Thus, its inhibition should support radiation treatment and increase its efficacy. On the other hand, there is evidence that radiation alone or in combi