Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Martin Oft"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Discovered over 4 decades ago in the supernatants of activated T cells, interleukin-2 (IL-2) is a potent pleiotropic cytokine involved in the regulation of immune responses. It is required for effector T cell expansion and differentiation as well as
Externí odkaz:
https://doaj.org/article/5d4cfa6eb67d40a39707720e5b598a52
Autor:
Martin Oft, Mohammed Ali, Ryan Burgess, Michele Bauer, Deepti Rokkam, Navneet Ratti, Sandro Vivona, Patrick Lupardus, Paul-Joseph Aspuria, Marie Semana, Ivan Cheng, Mahalaksmi Ramadass, Henry Rosas, George Zheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/161db09967f94eabbee53cd6b0f72813
Autor:
Martin Oft, Michael Totagrande, Luis Zuniga, David B Rosen, Priyanka Balasubrahmanyam, Zhenya Koliesnik, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/3e0b02efc0da4cb49b22cd8ab1e23832
Autor:
Khalil Choucair, Jesse D. Kelso, Joseph R. Duff, Christine S. Cassidy, Mary T. Albrethsen, Mushtaq Ashraf, Cherian Verghese, Martin Oft, F. Charles Brunicardi, Lance Dworkin, John Nemunaitis
Publikováno v:
Case Reports in Oncology, Vol 12, Iss 1, Pp 297-303 (2019)
Anemia in cancer patients is associated with poor quality of life, reduced response to therapy, and decreased overall survival. We describe a case of a 56-year old woman with advanced metastatic non-small cell lung carcinoma who demonstrated marked r
Externí odkaz:
https://doaj.org/article/43dba1a00c91440cbddd6cc1d53768c5
Autor:
Ivan H Chan, Dennis Van Hoof, Marina Abramova, Melissa Bilardello, Elliot Mar, Brett Jorgensen, Scott McCauley, Harminder Bal, Martin Oft, Peter Van Vlasselaer, John B Mumm
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156229 (2016)
Interleukin-10 (IL-10) is a multifunctional cytokine that exerts potent context specific immunostimulatory and immunosuppressive effects. We have investigated the mechanism by which PEGylated rIL-10 regulates plasma cholesterol in mice and humans. In
Externí odkaz:
https://doaj.org/article/15d2efc8347b456ab596f17ca099b999
Autor:
Emma M. Lees, Paul Kirschmeier, Taiying Chen, Martin Oft, Yaolin Wang, Thierry Fischmann, William Windsor, Amin Nomeir, Ronald Doll, Michael P. Dwyer, Kamil Paruch, Wolfgang Seghezzi, Derek Wiswell, Deepa Prabhavalkar, Nicole Davis, Frances Shanahan, Timothy Guzi, David Parry
Cyclin-dependent kinases (CDK) are key positive regulators of cell cycle progression and attractive targets in oncology. SCH 727965 inhibits CDK2, CDK5, CDK1, and CDK9 activity in vitro with IC50 values of 1, 1, 3, and 4 nmol/L, respectively. SCH 727
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e0ea7d520b9834d95a3ebdda2b8725
https://doi.org/10.1158/1535-7163.c.6532211
https://doi.org/10.1158/1535-7163.c.6532211
Autor:
Emma M. Lees, Paul Kirschmeier, Taiying Chen, Martin Oft, Yaolin Wang, Thierry Fischmann, William Windsor, Amin Nomeir, Ronald Doll, Michael P. Dwyer, Kamil Paruch, Wolfgang Seghezzi, Derek Wiswell, Deepa Prabhavalkar, Nicole Davis, Frances Shanahan, Timothy Guzi, David Parry
Supplementary Table 1 from Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87743110b3af2214b732c04514d49e0
https://doi.org/10.1158/1535-7163.22486046
https://doi.org/10.1158/1535-7163.22486046
Autor:
Emma M. Lees, Paul Kirschmeier, Taiying Chen, Martin Oft, Yaolin Wang, Thierry Fischmann, William Windsor, Amin Nomeir, Ronald Doll, Michael P. Dwyer, Kamil Paruch, Wolfgang Seghezzi, Derek Wiswell, Deepa Prabhavalkar, Nicole Davis, Frances Shanahan, Timothy Guzi, David Parry
Supplementary Table 2 from Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07006feba4bdfc4da262db0f34fd80d5
https://doi.org/10.1158/1535-7163.22486043.v1
https://doi.org/10.1158/1535-7163.22486043.v1
Autor:
Maria Lia Palomba, Matthew G. Mei, Paolo F. Caimi, Matthew Cortese, Marco Davila, Greg Yadnik, Nestor Huang, David Mou, Martin Oft, Paul-Joseph Aspuria, Anita Mehta-Damani, Navneet Ratti, Naiyer Rizvi, Alex Azrilevich, Ran Reshef
Publikováno v:
Cancer Research. 83:CT125-CT125
Background: Chimeric antigen receptor T cell therapy (CAR T) has demonstrated remarkable clinical efficacy in hematological malignancies. However, compromised T cell effector function, proliferation, and persistence can limit CAR T from reaching thei
Autor:
Martin Oft, Navneet Ratti, Sandro Vivona, Jan Emmerich, Romina Riener, Ievgen O. Koliesnik, Scott McCauley, Michele Bauer, Marie Semana, Deepti Rokkam, Bhargavi Jayaraman, Rene de Waal Malefyt, Paul-Joseph Aspuria, Michael Totagrande, Anita Mehta-Damani, Patrick J. Lupardus, Rob A. Kastelein
Publikováno v:
Cancer Research. 83:1801-1801
High-dose Interleukin-2 (IL-2) monotherapy induces complete responses in cancer patients but its use is limited by acute vascular toxicities including capillary leak syndrome and severe hypotension 1,2. IL-2 activates lymphocytes and NK-cells through