Zobrazeno 1 - 10
of 526
pro vyhledávání: '"Martin O. Leach"'
Autor:
Egidio Iorio, Franca Podo, Martin O. Leach, Jason Koutcher, Francis G. Blankenberg, Joseph F. Norfray
Publikováno v:
European Radiology Experimental, Vol 5, Iss 1, Pp 1-14 (2021)
Abstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalli
Externí odkaz:
https://doaj.org/article/7eab32bd967a475aa537574c96e0a0eb
Autor:
Sebastian Curcean, M.B.B.S., Lin Cheng, PhD, Simona Picchia, MD, Nina Tunariu, MD, David Collins, PhD, Matthew Blackledge, PhD, Sanjay Popat, MD, Mary O’Brien, MD, Anna Minchom, MD, Martin O. Leach, PhD, Dow-Mu Koh, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 12, Pp 100253- (2021)
Introduction: We compared the magnetic resonance imaging total tumor volume (TTV) and median apparent diffusion coefficient (ADC) of malignant pleural mesothelioma (MPM) before and at 4 weeks after chemotherapy, to evaluate whether these are potentia
Externí odkaz:
https://doaj.org/article/572e9a8380774a418ac096766e983c19
Autor:
Matthew D. Blackledge, Nina Tunariu, Fabio Zugni, Richard Holbrey, Matthew R. Orton, Ana Ribeiro, Julie C. Hughes, Erica D. Scurr, David J. Collins, Martin O. Leach, Dow-Mu Koh
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Purpose: To characterize the voxel-wise uncertainties of Apparent Diffusion Coefficient (ADC) estimation from whole-body diffusion-weighted imaging (WBDWI). This enables the calculation of a new parametric map based on estimates of ADC and ADC uncert
Externí odkaz:
https://doaj.org/article/eaf996e6cb034a1c8afb3a03dc0e6d73
Autor:
Anant Shah, Teresa Delgado-Goni, Teresa Casals Galobart, Slawomir Wantuch, Yann Jamin, Martin O. Leach, Simon P. Robinson, Jeffrey Bamber, Mounia Beloueche-Babari
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Targeted therapies specific to the BRAF-MEK-ERK signaling pathway have shown great promise in the treatment of malignant melanoma in the last few years, with these drugs now commonly used in clinic. Melanoma cells treated using these agents
Externí odkaz:
https://doaj.org/article/70160c2970da4f94b357818550a07a16
Autor:
Matthew D. Blackledge, Jessica M. Winfield, Aisha Miah, Dirk Strauss, Khin Thway, Veronica A. Morgan, David J. Collins, Dow-Mu Koh, Martin O. Leach, Christina Messiou
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Multi-parametric MRI provides non-invasive methods for response assessment of soft-tissue sarcoma (STS) from non-surgical treatments. However, evaluation of MRI parameters over the whole tumor volume may not reveal the full extent of post
Externí odkaz:
https://doaj.org/article/437d6e4b1f514e6a9f1cbd58dd2ca830
Autor:
Jessica M. Winfield, Aisha B. Miah, Dirk Strauss, Khin Thway, David J. Collins, Nandita M. deSouza, Martin O. Leach, Veronica A. Morgan, Sharon L. Giles, Eleanor Moskovic, Andrew Hayes, Myles Smith, Shane H. Zaidi, Daniel Henderson, Christina Messiou
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Purpose: To evaluate repeatability of quantitative multi-parametric MRI in retroperitoneal sarcomas, assess parameter changes with radiotherapy, and correlate pre-operative values with histopathological findings in the surgical specimens.Materials an
Externí odkaz:
https://doaj.org/article/fcef8f9e2c234497b8d17ce725bc4caf
Autor:
Lauren C. J. Baker, Arti Sikka, Jonathan M. Price, Jessica K. R. Boult, Elise Y. Lepicard, Gary Box, Yann Jamin, Terry J. Spinks, Gabriela Kramer-Marek, Martin O. Leach, Suzanne A. Eccles, Carol Box, Simon P. Robinson
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Overexpression of EGFR is a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Patients with HNSCC who respond to EGFR-targeted tyrosine kinase inhibitors (TKIs) eventually develop acquired resistance. Strategies
Externí odkaz:
https://doaj.org/article/4b307fd5e38d4e0793909c5ae7e61df4
Autor:
Colleen Bailey, David J. Collins, Nina Tunariu, Matthew R. Orton, Veronica A. Morgan, Thorsten Feiweier, David J. Hawkes, Martin O. Leach, Daniel C. Alexander, Eleftheria Panagiotaki
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
PurposeTo examine the usefulness of rich diffusion protocols with high b-values and varying diffusion time for probing microstructure in bone metastases. Analysis techniques including biophysical and mathematical models were compared with the clinica
Externí odkaz:
https://doaj.org/article/aa24ac2098dc44dbb9211d79c844d27c
Autor:
Deborah K. Hill, Andreas Heindl, Konstantinos Zormpas-Petridis, David J. Collins, Leslie R. Euceda, Daniel N. Rodrigues, Siver A. Moestue, Yann Jamin, Dow-Mu Koh, Yinyin Yuan, Tone F. Bathen, Martin O. Leach, Matthew D. Blackledge
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Diffusion-weighted magnetic resonance imaging (DWI) enables non-invasive, quantitative staging of prostate cancer via measurement of the apparent diffusion coefficient (ADC) of water within tissues. In cancer, more advanced disease is often character
Externí odkaz:
https://doaj.org/article/8bccd82feb6548fa819ce2cb788c94bc
Autor:
Martyn N.J. Paley, Araminta Ledger, Martin O. Leach, Craig Cummings, Raymond Hughes, Ali Akgun
Publikováno v:
Technologies, Vol 1, Iss 3, Pp 44-53 (2013)
MRI-guidance is increasingly used for minimally-invasive procedures, such as biopsy, and requires real-time active tracking of surgical instruments. Although optical and MR-based fiducial tracking devices have been used, these systems rely on complex
Externí odkaz:
https://doaj.org/article/2129d8d7cafb4ed4acb9d002a89ed944