Zobrazeno 1 - 10
of 484
pro vyhledávání: '"Martin O, Leach"'
Autor:
Mihaela Rata, Khurum Khan, David J Collins, Dow-Mu Koh, Nina Tunariu, Maria Antonietta Bali, James d’Arcy, Jessica M Winfield, Simona Picchia, Nicola Valeri, Ian Chau, David Cunningham, Matteo Fassan, Martin O Leach, Matthew R Orton
Publikováno v:
Cancer Imaging, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Diffusion weighted imaging (DWI) with intravoxel incoherent motion (IVIM) modelling can inform on tissue perfusion without exogenous contrast administration. Dynamic-contrast-enhanced (DCE) MRI can also characterise tissue perfusi
Externí odkaz:
https://doaj.org/article/54d6e0e5e80f43fc874ccfe2a6ae6ee5
Autor:
Martin O Leach, Stefan Winzeck, Christina Messiou, Martin Kaiser, Andrea Rockall, Ben Glocker, Laura Satchwell, Linda Wedlake, Emily Greenlay, Xingfeng Li, Tara Barwick, Theodore Barfoot, Simon Doran, Dow Mu Koh, Talha Qaiser, Eric Aboagye
Publikováno v:
BMJ Open, Vol 12, Iss 10 (2022)
Introduction Whole-body MRI (WB-MRI) is recommended by the National Institute of Clinical Excellence as the first-line imaging tool for diagnosis of multiple myeloma. Reporting WB-MRI scans requires expertise to interpret and can be challenging for r
Externí odkaz:
https://doaj.org/article/936d6bb85ab04412a16ec1ae345806aa
Autor:
Egidio Iorio, Franca Podo, Martin O. Leach, Jason Koutcher, Francis G. Blankenberg, Joseph F. Norfray
Publikováno v:
European Radiology Experimental, Vol 5, Iss 1, Pp 1-14 (2021)
Abstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalli
Externí odkaz:
https://doaj.org/article/7eab32bd967a475aa537574c96e0a0eb
Autor:
Sebastian Curcean, M.B.B.S., Lin Cheng, PhD, Simona Picchia, MD, Nina Tunariu, MD, David Collins, PhD, Matthew Blackledge, PhD, Sanjay Popat, MD, Mary O’Brien, MD, Anna Minchom, MD, Martin O. Leach, PhD, Dow-Mu Koh, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 12, Pp 100253- (2021)
Introduction: We compared the magnetic resonance imaging total tumor volume (TTV) and median apparent diffusion coefficient (ADC) of malignant pleural mesothelioma (MPM) before and at 4 weeks after chemotherapy, to evaluate whether these are potentia
Externí odkaz:
https://doaj.org/article/572e9a8380774a418ac096766e983c19
Autor:
Matthew D. Blackledge, Nina Tunariu, Fabio Zugni, Richard Holbrey, Matthew R. Orton, Ana Ribeiro, Julie C. Hughes, Erica D. Scurr, David J. Collins, Martin O. Leach, Dow-Mu Koh
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Purpose: To characterize the voxel-wise uncertainties of Apparent Diffusion Coefficient (ADC) estimation from whole-body diffusion-weighted imaging (WBDWI). This enables the calculation of a new parametric map based on estimates of ADC and ADC uncert
Externí odkaz:
https://doaj.org/article/eaf996e6cb034a1c8afb3a03dc0e6d73
Autor:
Anant Shah, Teresa Delgado-Goni, Teresa Casals Galobart, Slawomir Wantuch, Yann Jamin, Martin O. Leach, Simon P. Robinson, Jeffrey Bamber, Mounia Beloueche-Babari
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Targeted therapies specific to the BRAF-MEK-ERK signaling pathway have shown great promise in the treatment of malignant melanoma in the last few years, with these drugs now commonly used in clinic. Melanoma cells treated using these agents
Externí odkaz:
https://doaj.org/article/70160c2970da4f94b357818550a07a16
Autor:
Matthew D. Blackledge, Jessica M. Winfield, Aisha Miah, Dirk Strauss, Khin Thway, Veronica A. Morgan, David J. Collins, Dow-Mu Koh, Martin O. Leach, Christina Messiou
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Multi-parametric MRI provides non-invasive methods for response assessment of soft-tissue sarcoma (STS) from non-surgical treatments. However, evaluation of MRI parameters over the whole tumor volume may not reveal the full extent of post
Externí odkaz:
https://doaj.org/article/437d6e4b1f514e6a9f1cbd58dd2ca830
Autor:
Jessica M. Winfield, Aisha B. Miah, Dirk Strauss, Khin Thway, David J. Collins, Nandita M. deSouza, Martin O. Leach, Veronica A. Morgan, Sharon L. Giles, Eleanor Moskovic, Andrew Hayes, Myles Smith, Shane H. Zaidi, Daniel Henderson, Christina Messiou
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Purpose: To evaluate repeatability of quantitative multi-parametric MRI in retroperitoneal sarcomas, assess parameter changes with radiotherapy, and correlate pre-operative values with histopathological findings in the surgical specimens.Materials an
Externí odkaz:
https://doaj.org/article/fcef8f9e2c234497b8d17ce725bc4caf
Autor:
Mounia Beloueche-Babari, Martin O. Leach, Paul Workman, Richard Marais, Harold G. Parkes, Slawomir Wantuch, Maria Falck Miniotis, Teresa Delgado-Goni
Supplementary material and methods: -Western blotting -Quantitative real-time PCR (qRT-PCR) -Reactive oxygen species (ROS) production assay -NMR metabolic analyses of cells -NMR data acquisition and processing -Measurements of ADP/ATP ratios Suppleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19221ae3f8d6c4299eaccdc099e7c74d
https://doi.org/10.1158/1535-7163.22508643.v1
https://doi.org/10.1158/1535-7163.22508643.v1
Autor:
Anthony W. Tolcher, Johann S. de Bono, Daniel M. Sullivan, Michelle D. Garrett, Martin O. Leach, Nandita M. deSouza, Karen Swales, Simon P. Heaton, Shaun Decordova, Ruth Riisnaes, Lisa Lupinacci, Robert A. Beckman, Ernestina Tetteh, Liliana Delgado, Richard Baird, David Olmos, Kyriakos P. Papadopoulos, Ivy Fearen, Andrea Biondo, Nina Tunariu, Amita Patnaik, Li Yan, Timothy A. Yap
Purpose: Multiple cancers harbor genetic aberrations that impact AKT signaling. MK-2206 is a potent pan-AKT inhibitor with a maximum tolerated dose (MTD) previously established at 60 mg on alternate days (QOD). Due to a long half-life (60–80 hours)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371b991de3bf1445c0c528ebbb3b29a7
https://doi.org/10.1158/1078-0432.c.6523710.v1
https://doi.org/10.1158/1078-0432.c.6523710.v1