Výsledky vyhledávání - "Martin N. Kenworthy"

Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

Autor: Christopher John Squire, Simone Tomasi, Julie Reilly, Kevin William Leslie, Denise Watt, Lianne Frodsham, David J. Klauber, Michael David Golden, Claire S. MacLeod, Martin N. Kenworthy, Andrew S. Wells, Rebecca E. Meadows, Susan Hard, Keith R. Mulholland

Publikováno v: Organic Process Research & Development. 17:1123-1130

ω-Transaminase enzyme chemistry provides an excellent methodology to build synthetically useful chiral amines from their corresponding ketones. An application of this methodology, providing a long-term commercial manufacturing route to a JAK2 kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebc65a2e80bdcc5e235569e3cc72e9bc
https://doi.org/10.1021/op400133d

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The Preparation of α-Alkylidene-γ-Butyrolactones Using a Telescoped Intramolecular Michael/Olefination (TIMO) Sequence: Synthesis of (+)-Paeonilactone B

Autor: Mark S. Scott, Richard J. K. Taylor, Michael G. Edwards, Martin N. Kenworthy, Alexis Perry, Adrian C. Whitwood, Russell R. A. Kitson

Publikováno v: European Journal of Organic Chemistry. 2008:4769-4783

A novel telescoped intramolecular Michael addition/proton transfer/HWE olefination sequence has been developed to provide rapid access to α-alkylidene-γ-butyrolactones. This methodology has been applied to prepare a range of tetrahydrobenzofuran-2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ddd63839299264db3deea0c6e0946b9
https://doi.org/10.1002/ejoc.200800558

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The preparation of simplified scyphostatin analogues using a tethered aminohydroxylation (TA) strategy

Autor: Martin N. Kenworthy, Richard J. K. Taylor, Graeme D. McAllister

Publikováno v: Tetrahedron Letters. 45:6661-6664

The first tethered aminohydroxylation reaction employing a tertiary alcohol is reported as part of a route to prepare analogues of the naturally occurring sphingomyelinase inhibitor, scyphostatin. The tethered aminohydroxylation of 1-allylcyclohexano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68aa7b9b3ededc80fbf7ceacc1aaf88c
https://doi.org/10.1016/j.tetlet.2004.07.012

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Cyclisations of Organolithiums onto Aromatic Rings

Autor: Jonathan Clayden, Martin N. Kenworthy

Publikováno v: Synthesis. 2004:1721-1736

A review on synthesis of bicyclic and polycyclic arom. compds. contg. condensed five-membered rings by cyclization of lithiated arom. hydrocarbons and their functional derivs. An intramol. nucleophilic attack of lithiated arom. and alkylarom. compds.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61b78dc96c41811b03b3b10418c36fcd
https://doi.org/10.1055/s-2004-829138

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Highly Functionalized Organolithium Reagents for Enantiomerically Pure α-Amino Acid Synthesis

Autor: John Paul Kilburn, Richard J. K. Taylor, Martin N. Kenworthy

Publikováno v: Organic Letters. 6:19-22

[reaction: see text] Highly functionalized l-serine-derived organolithium reagents have been generated and reacted with a variety of electrophiles, delivering novel enantiomerically pure adducts. These adducts were then converted into homochiral amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58840f82c226bd46b93e0e7a5166317a
https://doi.org/10.1021/ol0360039

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Dearomatizing Annelation of Five-Membered Rings to Naphthalenes by Organolithium Cyclization

Autor: Martin N. Kenworthy, Jonathan Clayden

Publikováno v: Organic Letters. 4:787-790

[reaction: see text] gamma-Lithiopropylnaphthalenes and their oxa- and aza-tethered analogues cyclize by nucleophilic addition of the organolithium to the naphthalene ring. The resulting benzyllithiums react stereoselectively with electrophiles to gi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063a3bb81a09f1494e794f55da14f9b9
https://doi.org/10.1021/ol0172626

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Axial chirality in xanthene-4,5-dicarboxamides: 1,9-stereocontrol mediated by remote interactions between conformationally constrained amide groups

Autor: Jonathan Clayden, Madeleine Helliwell, Latifa H. Youssef, Martin N. Kenworthy

Publikováno v: Tetrahedron Letters. 41:5171-5175

Tertiary 9,9-dimethylxanthene-4,5-dicarboxamides have a C 2 -symmetric, axially chiral ground state due to remote interactions between the conformationally constrained tertiary amide substituents. Double ortholithiation–alkylation blocks amide rota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::058b0d4a3027dd8eecda6ad60cd02885
https://doi.org/10.1016/s0040-4039(00)00833-9

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