Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Martin Mikl"'
Autor:
Miriam I. Rosenberg, Erez Greenstein, Martin Buchkovich, Ayelet Peres, Eric Santoni-Rugiu, Lei Yang, Martin Mikl, Zalman Vaksman, David L. Gibbs, Dan Reshef, Amy Salovin, Meredith S. Irwin, Arlene Naranjo, Igor Ulitsky, Pedro A. de Alarcon, Katherine K. Matthay, Victor Weigman, Gur Yaari, Jessica A. Panzer, Nir Friedman, John M. Maris
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112879- (2023)
Summary: Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainst
Externí odkaz:
https://doaj.org/article/506516905d124cd99326d2bc5f05f4f1
A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing
Autor:
Roi Isaac, Yaron Vinik, Martin Mikl, Shani Nadav-Eliyahu, Hadas Shatz-Azoulay, Adi Yaakobi, Natalie DeForest, Amit R. Majithia, Nicholas J.G. Webster, Yaron Shav-Tal, Eytan Elhanany, Yehiel Zick
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105270- (2022)
Summary: The seven-transmembrane superfamily member 3 protein (TM7SF3) is a p53-regulated homeostatic factor that attenuates cellular stress and the unfolded protein response. Here we show that TM7SF3 localizes to nuclear speckles; eukaryotic nuclear
Externí odkaz:
https://doaj.org/article/d368cbd385c84aec818ba9cba0005b80
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes. Here the authors present an approach that can assess the frameshifting potential of a sequence and
Externí odkaz:
https://doaj.org/article/82e2217d97d24ceda90271fe670fb62c
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Alternative splicing is regulated by multiple mechanisms. Here the authors employed designed splice site libraries and massively parallel reporter assays to dissect the regulatory complexity and cell-to-cell variability of splicing decisions and to b
Externí odkaz:
https://doaj.org/article/95b4244dfa974dfc918f1c413b6e0f69
Autor:
Martin Mikl, Carrie R. Cowan
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1380-1390 (2014)
Cell polarity in one-cell C. elegans embryos guides asymmetric cell division and cell-fate specification. Shortly after fertilization, embryos establish two antagonistic cortical domains of PAR proteins. Here, we find that the conserved polarity fact
Externí odkaz:
https://doaj.org/article/a29d60ae39e14cc7898e84f4b8035796
Autor:
Marlène Jagut, Patricia Hamminger, Alexander Woglar, Sophia Millonigg, Luis Paulin, Martin Mikl, Maria Rosaria Dello Stritto, Lois Tang, Cornelia Habacher, Angela Tam, Miguel Gallach, Arndt von Haeseler, Anne M Villeneuve, Verena Jantsch
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002412 (2016)
During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are ind
Externí odkaz:
https://doaj.org/article/cd3b020c8f314c0b802f8532a5545f5e
Autor:
Martin Mikl, Davide Eletto, Malak Nijim, Minkyoung Lee, Atefeh Lafzi, Farah Mhamedi, Orit David, Simona Baghai Sain, Kristina Handler, Andreas E Moor
Publikováno v:
Nucleic Acids Research
Asymmetric subcellular mRNA localization allows spatial regulation of gene expression and functional compartmentalization. In neurons, localization of specific mRNAs to neurites is essential for cellular functioning. However, it is largely unknown ho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human viruses such as HIV and SARS coronavirus and is critical for their replication. Here, we
Autor:
Martin Mikl, Yehiel Zick, Eytan Elhanany, Natali DeForest, Yaron Vinik, Hadas Shatz-Azoulay, Roi Isaac, Adi Yaakobi, Amit R. Majithia, Nicholas J. G. Webster
Publikováno v:
SSRN Electronic Journal.
The seven-transmembrane superfamily member 3 protein (TM7SF3) is a p53-regulated homeostatic factor that attenuates the development of cellular stress and unfolded protein response. Here we show that TM7SF3 localizes to nuclear speckles; eukaryotic n
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Most human genes are alternatively spliced, allowing for a large expansion of the proteome. The multitude of regulatory inputs to splicing limits the potential to infer general principles from investigating native sequences. Here, we create a rationa