Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Martin Mense"'
Autor:
Edward J. Sanderlin, Melissa M. Keenan, Martin Mense, Alexey S. Revenko, Brett P. Monia, Shuling Guo, Lulu Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Currently, there is no therapy for patients with cystic fibrosis caused by nonsense mutations. Here the authors show that CFTR mRNAs with nonsense codons are predominantly degraded by the SMG6-mediated branch of the NMD pathway, providing potential t
Externí odkaz:
https://doaj.org/article/0bd6da00b0e3497583db276b1d3e35c5
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz:
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
Autor:
Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.
Externí odkaz:
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Autor:
Cody J. Aros, David W Shia, Changfu Yao, Kathrin Plath, Preethi Vijayaraj, Eszter K. Vladar, Gianni Carraro, Arunima Purkayastha, Martin Mense, Emily J. Wilson, Jason Ernst, Justin Langerman, Barry R. Stripp, Aleks Szymaniak, Guangzhu Zhang, Shan Sabri, Ben A Calvert, Tammy M. Rickabaugh, Amy L. Ryan, Brigitte N. Gomperts, Bindu Konda, Edo Israely, Andrew J. Lund, Zareeb Lorenzana, Junjie Lu, John Mahoney, Scott H. Randell, Michael Mulligan, Priyanka Bhatt
Publikováno v:
Nat Med
Nature medicine, vol 27, iss 5
Nature medicine, vol 27, iss 5
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000 people. People with CF experience multi-organ dysfunction resulting from aberrant electrolyte transport across polarized epithelia due to mutations in the cy
Autor:
Gregory A. Newby, Luke H. Rhym, Hermann Bihler, Zhiping Weng, Martin Mense, Tingting Jiang, Wen Xue, Xiao-Ou Zhang, Y. Cheng, Jordana M. Henderson, H. Valley, Yueying Cao, Anton P. McCaffrey, Daniel G. Anderson, David R. Liu, Qin Wang, Kevin Coote
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain
Autor:
Edward Sanderlin, Shuling Guo, Alexey S. Revenko, Melissa M. Keenan, Martin Mense, Lulu Huang, Brett P. Monia
Cystic fibrosis is caused by loss of function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in severe lung disease. Nearly 10% of cystic fibrosis patients have at least one CFTR allele with a nonsense muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd631e113470b378c96730c1c6cf515
https://doi.org/10.21203/rs.3.rs-800274/v1
https://doi.org/10.21203/rs.3.rs-800274/v1
Autor:
B. Bostwick, Ning Peng, E. Mendenhall, M. Du, Eric Wong, David M. Bedwell, Kim M. Keeling, R. Green, K. Thrasher, Martin Mense, C. Coppola, Venkateshwar Mutyam, M. Suto, Eric J. Sorscher, Jerome Mahiou, L. Fu, J. Wangen, J. Chen, B. Mathew, Yao Li, A. Rab, Hermann Bihler, Jeong S. Hong, Steven M. Rowe, K. Liu, J. Sharma, J. Saltz, Feng Liang, L. Tang, C. Augelli-Szafran
Publikováno v:
Journal of Cystic Fibrosis. 20:S250-S251
Publikováno v:
Journal of Cystic Fibrosis. 20:S282-S283
Autor:
Martin Mense, Calvin U. Cotton, J. Harrington, N. Allaire, Andrey Sivachenko, J. Conte, B. Tabak, Hermann Bihler, E. Wilson, A. LaPan, H. Valley
Publikováno v:
Journal of Cystic Fibrosis. 20:S302-S303