Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Martin Melcher"'
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003430 (2013)
During blood stage infection, Plasmodium falciparum infected erythrocytes (IE) bind to host blood vessels. This virulence determinant enables parasites to evade spleen-dependent killing mechanisms, but paradoxically in some cases may reduce parasite
Externí odkaz:
https://doaj.org/article/287b3d6669de49d2a81320fa18e38957
Autor:
Sowmya Sampath, Chris Carrico, Joel Janes, Sairam Gurumoorthy, Claire Gibson, Martin Melcher, Chetan E Chitnis, Ruobing Wang, William R Schief, Joseph D Smith
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003420 (2013)
Glycan masking is an emerging vaccine design strategy to focus antibody responses to specific epitopes, but it has mostly been evaluated on the already heavily glycosylated HIV gp120 envelope glycoprotein. Here this approach was used to investigate t
Externí odkaz:
https://doaj.org/article/14ff8003af05497592930148dcb25170
Autor:
Joel H Janes, Christopher P Wang, Emily Levin-Edens, Inès Vigan-Womas, Micheline Guillotte, Martin Melcher, Odile Mercereau-Puijalon, Joseph D Smith
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002032 (2011)
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family plays a central role in antigenic variation and cytoadhesion of P. falciparum infected erythrocytes. PfEMP1 proteins/var genes are classified into three main subfamilies (UpsA,
Externí odkaz:
https://doaj.org/article/b6e5d923273545a9a9d046647aaca645
Autor:
David A. Fidock, Eric Hanssen, Rebecca A. Muhle, Shannon Kenny, Joseph D. Smith, Matthew W. A. Dixon, Steven Batinovic, Coralie Ode Millet, Martin Melcher, Mauro Maiorca, Leann Tilley, Paul J. McMillan
Publikováno v:
Cellular Microbiology. 15:1401-1418
The human malaria parasite, Plasmodium falciparum, modifies the red blood cells (RBCs) that it infects by exporting proteins to the host cell. One key virulence protein, P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1), is trafficked to the surf
Autor:
Rebecca A. Muhle, Inès Vigan-Womas, Joseph D. Smith, Odile Mercereau-Puijalon, Susan M. Kraemer, Marion Avril, Philipp P. Henrich, Martin Melcher, David A. Fidock
Publikováno v:
Cellular Microbiology. 12:1446-1462
Summary Transport of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) variants to the red blood cell (RBC) surface enables malarial parasite evasion of host immunity by modifying the antigenic and adhesive properties of infected RBCs. In
Publikováno v:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 6:61-69
A variety of different cell lineages of the hematopoietic system are activated during inflammatory processes. These cells not only contribute to the beneficial outcome of an immune response, but can also cause pathology such as autoimmunity as a cons
Autor:
Arie P. Otte, Thijs Hendrix, Richard George Antonius Bernardus Sewalt, Dieter Schweizer, Martin Melcher, Monika Lachner, Karien M. Hamer, Mark Vargas, Jan L. den Blaauwen, Thomas Jenuwein
Publikováno v:
Molecular and Cellular Biology. 22:5539-5553
Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of gene activity. Two distinct human PcG complexes have been characterized. The EED/EZH2 PcG complex utilizes histone deace
Autor:
Alexander Schleiffer, Josef Loidl, Michael F. Jantsch, Dieter Schweizer, Martin Melcher, Pawel Pasierbek
Publikováno v:
Genes & Development. 15:1349-1360
We have studied four Caenorhabditis elegans homologs of the Rad21/Scc1/Rec8 sister-chromatid cohesion protein family. Based on the RNAi phenotype and protein localization, it is concluded that one of them, W02A2.6p, is the likely worm ortholog of yea
Autor:
Philipp Selenko, Thomas Jenuwein, Manfred Schmid, Götz Laible, Martin Melcher, Louise Aagaard
Publikováno v:
Molecular and Cellular Biology. 20:3728-3741
Higher-order chromatin is essential for epigenetic gene control and for the structural organization of chromosomes at centromeres and telomeres (21, 26, 35, 36). Despite these important functions, only very few components of higher-order chromatin, p
Autor:
Brian J. Haas, Caitlin A. Tolzmann, Martin Melcher, Malcolm J. Gardner, Joseph D. Smith, Jean E. Feagin, Xiaohong Zhang
Publikováno v:
Eukaryotic cell. 10(11)
Splicing of mRNA is an ancient and evolutionarily conserved process in eukaryotic organisms, but intron-exon structures vary. Plasmodium falciparum has an extreme AT nucleotide bias (>80%), providing a unique opportunity to investigate how evolutiona