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of 8
pro vyhledávání: '"Martin Meagher"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14678 (2022)
A six-subunit ATPase ring forms the central hub of the replication forks in all domains of life. This ring performs a helicase function to separate the two complementary DNA strands to be replicated and drives the replication machinery along the DNA.
Externí odkaz:
https://doaj.org/article/a80db5d37a9b4e46ae5b2995ded9fbe9
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combin
Externí odkaz:
https://doaj.org/article/da3d2f86275a48fca8e4523d176c6988
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Cells strongly regulate DNA replication to ensure genomic stability and prevent several diseases, including cancers. Eukaryotes and archaea strictly control DNA-replication initiation by the regulated loading of hexameric minichromosome maintenance (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7149235a9ce28374bf31f3fa6e50237
https://doi.org/10.1107/s2053230x21005331
https://doi.org/10.1107/s2053230x21005331
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
The DNA translocation activity of the minichromosome maintenance (MCM) complex powers DNA strand separation of the replication forks of eukaryotes and archaea. Here we illustrate an atomic level mechanism for this activity with a crystal structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c47cf8d2809c392e2bb1167814d76c
https://doaj.org/article/da3d2f86275a48fca8e4523d176c6988
https://doaj.org/article/da3d2f86275a48fca8e4523d176c6988
Autor:
Eric J. Enemark, Martin Meagher
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:545-551
The crystal structure of the N-terminal domain of thePyrococcus furiosusminichromosome maintenance (MCM) protein as a double hexamer is described. The MCM complex is a ring-shaped helicase that unwinds DNA at the replication fork of eukaryotes and ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffca5f029b5d9f1771d90c87f45525ca
https://doi.org/10.1107/s2053230x1600858x
https://doi.org/10.1107/s2053230x1600858x
Autor:
Shih-Chieh, Chiang, Martin, Meagher, Nick, Kassouf, Majid, Hafezparast, Peter J, McKinnon, Rachel, Haywood, Sherif F, El-Khamisy
Publikováno v:
Science Advances
Mitochondrial protein-linked DNA repair promotes gene transcription and protects from free radical–induced DNA damage.
Breakage of one strand of DNA is the most common form of DNA damage. Most damaged DNA termini require end-processing in prep
Breakage of one strand of DNA is the most common form of DNA damage. Most damaged DNA termini require end-processing in prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::092473163c5b6e1ad63f9ee31dac980f
https://pubmed.ncbi.nlm.nih.gov/28508041
https://pubmed.ncbi.nlm.nih.gov/28508041
Autor:
Martin, Meagher, Robert N, Lightowlers
Publikováno v:
Biochimie
In recent years, our knowledge surrounding mammalian mitochondrial DNA (mtDNA) damage and repair has increased significantly. Greater insights into the factors that govern mtDNA repair are being elucidated, thus contributing to an increase in our und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2fe052516ca391e1390ff2cb083610a
https://pubmed.ncbi.nlm.nih.gov/24161509
https://pubmed.ncbi.nlm.nih.gov/24161509
Autor:
Martin Meagher, Philippa D. Hepplewhite, Eve M. Simcox, Douglass M. Turnbull, Amy K. Reeve, Nichola Z. Lax, Evelyn Jaros
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(26)
Mitochondrial defects within substantia nigra (SN) neurons are implicated in the pathogenesis of Parkinson's disease. SN neurons show increased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunction, although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b676a04dc10134fb130e1691ff9ed022
https://pubmed.ncbi.nlm.nih.gov/24114880
https://pubmed.ncbi.nlm.nih.gov/24114880