Výsledky vyhledávání - "Martin Maxmilian Kaiser"

Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)

Autor: Gabriel Birkus, Miroslav Smola, Petra Břehová, Lubomír Rulíšek, Martin Maxmilian Kaiser, Michal Šála, Aleš Marek, Martin Dračínský, Andrea Brázdová, Barbora Novotna, Zlatko Janeba, Milan Dejmek, Joshua R. Smith, Markéta Pimková Polidarová, Radim Nencka, Ondřej Páv, Evzen Boura, Ondrej Gutten

Publikováno v: Journal of Medicinal Chemistry. 64:7596-7616

Cyclic dinucleotides (CDNs) are second messengers that bind to the stimulator of interferon genes (STING) and trigger the expression of type I interferons and proinflammatory cytokines. Here we evaluate the activity of 3',3'-c-di(2'F,2'dAMP) and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c7c8621ad313e02166230b7d6d0b2
https://doi.org/10.1021/acs.jmedchem.1c00301

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Development of Scalable Synthesis of 5-Butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a Dual Inhibitor of Nitric Oxide and Prostaglandin E2 Production

Autor: Miroslav Havránek, Zlatko Janeba, Ondřej Baszczyňski, Martin Maxmilian Kaiser, Viktor Kolman, Vladislav Kotek, Pavel Dosoudil

Publikováno v: Organic Process Research & Development. 24:1718-1724

We report a scalable efficient synthesis of 5-butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a dual inhibitor of nitric oxide and prostaglandin E2 production with potent anti-inflam...

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https://doi.org/10.1021/acs.oprd.0c00324

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Estimation of apparent binding constant of complexes of selected acyclic nucleoside phosphonates with β-cyclodextrin by affinity capillary electrophoresis

Autor: Veronika Šolínová, Hana Mikysková, Martin Maxmilian Kaiser, Antonín Holý, Zlatko Janeba, Václav Kašička

Publikováno v: ELECTROPHORESIS. 37:239-247

Affinity capillary electrophoresis (ACE) has been applied to estimation of apparent binding constant of complexes of (R,S)-enantiomers of selected acyclic nucleoside phosphonates (ANPs) with chiral selector β-cyclodextrin (βCD) in aqueous alkaline

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https://doi.org/10.1002/elps.201500337

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Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors ofPlasmodium falciparumand Human 6-Oxopurine Phosphoribosyltransferases

Autor: Tzu-Hsuan Wang, Michael D. Edstein, Lenka Poštová-Slavětínská, Dianne T. Keough, Martin Maxmilian Kaiser, Luke W. Guddat, Martin Dračínský, Dana Hocková, Eliška Procházková, Zlatko Janeba, Marina Chavchich

Publikováno v: ChemMedChem. 10:1707-1723

Acyclic nucleoside phosphonates (ANPs) are a promising class of antimalarial therapeutic drug leads that exhibit a wide variety of Ki values for Plasmodium falciparum (Pf) and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases [HG(X)PRT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbc2dd01704bb6a5049fdc59c5e4333
https://doi.org/10.1002/cmdc.201500322

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Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases

Autor: Luke W. Guddat, Martin Dračínský, Lenka Poštová-Slavětínská, Dianne T. Keough, Dana Hocková, Zlatko Janeba, Martin Maxmilian Kaiser, Ondřej Baszczyňski

Publikováno v: ChemMedChem. 12(14)

Acyclic nucleoside phosphonates (ANPs) are an important class of therapeutic drugs that act as antiviral agents by inhibiting viral DNA polymerases and reverse transcriptases. ANPs containing a 6-oxopurine unit instead of a 6-aminopurine or pyrimidin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ea976ebb3d3477edc89d93629c0c88
https://pubmed.ncbi.nlm.nih.gov/28628279

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An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli

Autor: Martin Maxmilian Kaiser, Martin Drančínský, Miroslav Otmar, Marcela Krečmerová, Petr Jansa, Blanka Králová, Jiří Blažek, Antonín Holý, Ondřej Baszczyňski

Publikováno v: Bioorganic & Medicinal Chemistry. 20:3111-3118

A new enzymatic method for the synthesis of β-galactosides of nucleosides and acyclic nucleoside analogues has been developed, using β-galactosidase from Escherichia coli as a catalyst and lactose as a sugar donor. The method is very rapid, feasibl

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https://doi.org/10.1016/j.bmc.2012.02.062

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A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid

Autor: Martin Dračínský, Martin Maxmilian Kaiser, Petr Jansa, Zlatko Janeba

Publikováno v: Tetrahedron

A convenient and efficient synthesis of a novel class of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid has been developed. The key step of the synthesis is the optimized oxidation of the 3-hydroxy-2-(phosphonomethoxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f1f92708782f69ee34298f7044e1b5
http://europepmc.org/articles/PMC7111817

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Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus

Autor: Petr Jansa, Ondřej Baszczyňski, Petra Břehová, Martin Maxmilian Kaiser, Michal Česnek, Zlatko Janeba, Robert Snoeck, Martin Dračínský, Graciela Andrei, Eliška Procházková

Publikováno v: Antiviral Chemistry & Chemotherapy, Vol 26 (2018)
Antiviral Chemistry and Chemotherapy
Antiviral Chemistry & Chemotherapy

While noncanonic xanthine nucleotides XMP/dXMP play an important role in balancing and maintaining intracellular purine nucleotide pool as well as in potential mutagenesis, surprisingly, acyclic nucleoside phosphonates bearing a xanthine nucleobase h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293c30d1d3b921dc53920c07440d743d
https://doi.org/10.1177/2040206618813050

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