Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Martin Machyna"'
Autor:
Alla Bulashevska, Zsófia Nacsa, Franziska Lang, Markus Braun, Martin Machyna, Mustafa Diken, Liam Childs, Renate König
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments. The convergence of immunogenomics, bioinformatics, and artificial intelligence (AI) has pro
Externí odkaz:
https://doaj.org/article/6bac69f6699b4b50b13fc7e5c1602254
Autor:
Edward Courchaine, Sara Gelles-Watnick, Martin Machyna, Korinna Straube, Sarah Sauyet, Jade Enright, Karla M. Neugebauer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Cajal bodies are membraneless organelles scaffolded by coilin protein. Here, coilin–coilin and coilin–Nopp140 interaction sites are identified and perturbed, revealing coilin’s capacity to form long fibrils and be remodeled into spherical struc
Externí odkaz:
https://doaj.org/article/7eeb5d4cbc71440580714fc8aff5e6da
Autor:
Franziska Hufsky, Ana B. Abecasis, Artem Babaian, Sebastian Beck, Liam Brierley, Simon Dellicour, Christian Eggeling, Santiago F. Elena, Udo Gieraths, Anh D. Ha, Will Harvey, Terry C. Jones, Kevin Lamkiewicz, Gabriel L. Lovate, Dominik Lücking, Martin Machyna, Luca Nishimura, Maximilian K. Nocke, Bernard Y. Renard, Shoichi Sakaguchi, Lygeri Sakellaridi, Jannes Spangenberg, Maria Tarradas-Alemany, Sandra Triebel, Yulia Vakulenko, Rajitha Yasas Wijesekara, Fernando González-Candelas, Sarah Krautwurst, Alba Pérez-Cataluña, Walter Randazzo, Gloria Sánchez, Manja Marz
Publikováno v:
Viruses, Vol 15, Iss 10, p 2031 (2023)
The 2023 International Virus Bioinformatics Meeting was held in Valencia, Spain, from 24–26 May 2023, attracting approximately 180 participants worldwide. The primary objective of the conference was to establish a dynamic scientific environment con
Externí odkaz:
https://doaj.org/article/43ba92c81ca34be08ad62fd1c2642010
Autor:
Giulia Biancon, Poorval Joshi, Joshua T. Zimmer, Torben Hunck, Yimeng Gao, Mark D. Lessard, Edward Courchaine, Andrew E.S. Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D. Simon, Karla M. Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Mol Cell
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9732eb1548edc00558760338c886ade
https://europepmc.org/articles/PMC8988922/
https://europepmc.org/articles/PMC8988922/
Autor:
Korinna Straube, Edward M. Courchaine, Martin Machyna, Jade Enright, Sarah Sauyet, Karla M. Neugebauer
Cajal bodies (CBs) are ubiquitous nuclear membraneless organelles (MLOs) that promote efficient biogenesis of RNA-protein complexes. Depletion of the CB scaffolding protein coilin is lethal for vertebrate embryogenesis, making CBs a strong model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26b6681b9a1234a19458f468f93680f
https://doi.org/10.1101/2021.08.01.454609
https://doi.org/10.1101/2021.08.01.454609
Autor:
Toma Tebaldi, Mark D. Lessard, Joshua T. Zimmer, Gabriella Viero, Poorval Joshi, Valentina Botti, Ashley Qin, Karla M. Neugebauer, Giulia Biancon, Torben Hunck, Rana Gbyli, Lea Kiefer, Andrew Es Barentine, Joerg Bewersdorf, Edward M. Courchaine, Yuanbin Song, Matthew D. Simon, Nils Neuenkirchen, Stephanie Halene, Martin Machyna, Haifan Lin, Amisha Patel, Yimeng Gao
Somatic mutations in splicing factors are of significant interest in myeloid malignancies and other cancers. U2AF1, together with U2AF2, is essential for 3’ splice site recognition. U2AF1 mutations result in aberrant splicing, but the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3ecf3e301da6963e53d2e34aaabe26
https://doi.org/10.1101/2021.04.22.441020
https://doi.org/10.1101/2021.04.22.441020
Publikováno v:
Nature structuralmolecular biology. 27(3)
Understanding the targeting and spreading patterns of long non-coding RNAs (lncRNAs) on chromatin requires a technique that can detect both high-intensity binding sites and reveal genome-wide changes in spreading patterns with high precision and conf
Autor:
Giulia Biancon, Poorval Joshi, Joshua T Zimmer, Torben Hunck, Yimeng Gao, Mark D Lessard, Edward Courchaine, Andrew ES Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D Simon, Karla M Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Blood. 138:321-321
Somatic mutations in splicing factor genes are drivers of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The splicing factors U2AF1 and U2AF2 form the U2AF heterodimer that is critical in the 3' splice site (3'SS) recognition and i
Autor:
Torben Hunck, Giulia Biancon, Rana Gbyli, Toma Tebaldi, Anastasia Ardasheva, Nils Neuenkirchen, Xiaoying Fu, Haifan Lin, Valentina Botti, Karla M. Neugebauer, Josh Zimmer, Matthew D. Simon, Amisha Patel, Martin Machyna, Gabriella Viero, Poorval Joshi, Stephanie Halene, Yimeng Gao, Ashley Taylor, Ashley Qin
Publikováno v:
Blood. 136:3-4
Spliceosomal gene mutations function as drivers of hematologic malignancies and other cancers with an occurrence of more than 50% in myelodysplastic syndromes and secondary acute myeloid leukemia. Hotspot mutations S34F and Q157R in the two zinc fing
Publikováno v:
Nature Structural & Molecular Biology. 27:400-400