Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Martin M. Lewinter"'
Autor:
Massimo Imazio, Allan L. Klein, Antonio Brucato, Antonio Abbate, Michael Arad, Paul C. Cremer, Antonella Insalaco, Martin M. LeWinter, Basil S. Lewis, David Lin, Sushil A. Luis, Stephen J. Nicholls, Paul Sutej, Yishay Wasserstrum, JoAnn Clair, Indra Agarwal, Sheldon Wang, John F. Paolini
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Background Rilonacept, a once‐weekly interleukin‐1 alpha and beta cytokine trap, reduced pericarditis recurrence in the phase 3 study, RHAPSODY (Rilonacept Inhibition of Interleukin‐1 Alpha and Beta for Recurrent Pericarditis: A Pivotal Symptom
Externí odkaz:
https://doaj.org/article/5b697727911f4cb89e0bb7e5b20b9221
Autor:
Antonio Brucato, Michelle Z. Lim‐Watson, Allan Klein, Massimo Imazio, David Cella, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, David Lin, Dor Lotan, Massimo Pancrazi, Lucia Trotta, Brittany Klooster, Leighann Litcher‐Kelly, Liangxing Zou, Matt Magestro, Alistair Wheeler, John F. Paolini
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)
Background Recurrent pericarditis is characterized by painful flares and inflammation, which negatively impact health‐related quality of life. RHAPSODY (rilonacept inhibition of interleukin‐1 alpha and beta for recurrent pericarditis: a pivotal s
Externí odkaz:
https://doaj.org/article/7862af8543b748e48f0455828f989d64
Autor:
David Lin, Allan Klein, David Cella, Anna Beutler, Fang Fang, Matt Magestro, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, Antonio Abbate, Andrew Ertel, Leighann Litcher-Kelly, Brittany Klooster, John F. Paolini
Publikováno v:
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Impact of recurrent pericarditis (RP) on patient health-related quality of life (HRQoL) was evaluated through qualitative patient interviews and as an exploratory endpoint in a Phase 2 trial evaluating the efficacy and safety of r
Externí odkaz:
https://doaj.org/article/ab3907060f944c99a33fcf27f303829b
Autor:
Daniel N. Silverman, Mehdi Rambod, Daniel L. Lustgarten, Robert Lobel, Martin M. LeWinter, Markus Meyer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 17 (2020)
Background Increases in heart rate are thought to result in incomplete left ventricular (LV) relaxation and elevated filling pressures in patients with heart failure with preserved ejection fraction (HFpEF). Experimental studies in isolated human myo
Externí odkaz:
https://doaj.org/article/bffe058803d94304b13f0c671a47b9b0
Autor:
Abraham Abernethy, Sadi Raza, Jie‐Lena Sun, Kevin J. Anstrom, Russell Tracy, Johannes Steiner, Peter VanBuren, Martin M. LeWinter
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 8 (2018)
BackgroundUnderlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction (HFpEF). In this study we tested the hypothesis that pro‐inflammatory biomarkers are elevated in patients with acutely decompensa
Externí odkaz:
https://doaj.org/article/7f49c8a3a9214b67a79a0c2d29ed8f07
Publikováno v:
Current Cardiology Reports. 24:915-923
Our goal in writing this review was to provide a comprehensive appraisal of current therapies for idiopathic recurrent pericarditis with a particular focus on the newest therapeutic agents. We sought to understand the role of the inflammasome in the
Autor:
Sushil Allen Luis, Martin M. LeWinter, Matthew Magestro, Maral DerSarkissian, Mei Sheng Duh, Rose Chang, Kalé Kponee-Shovein, Aruna Muthukumar, Xingdi Hu, Michelle Z. Lim-Watson, Allan L. Klein
Publikováno v:
Current Medical Research and Opinion. 38:1385-1389
To obtain a nationally representative annualized estimate of the prevalence of pericarditis (inflammation of the pericardium) in the United States (US) in order to better understand the potential burden on the health care system. Three nationally rep
Autor:
Martin M. LeWinter, Massimo Imazio, George Lazaros, Allan L. Klein, Antonio Abbate, Marco Gattorno, Antonio Brucato
Publikováno v:
European Heart Journal. 43:2946-2957
Anti-interleukin (IL)-1 agents have been developed for the treatment of autoinflammatory and rheumatic conditions, where overproduction of IL-1 is an important pathophysiologic process. IL-1α and IL-1β are the most studied members of the IL-1 famil
Autor:
Markus Meyer, Wolfgang R. Dostmann, J. Martin, Martin M. LeWinter, Michael J. Previs, Maren E. Arnold, Bradley M. Palmer
Publikováno v:
Am J Physiol Heart Circ Physiol
The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB-mediated increases in SERCA2a activity improve cardiac funct
Autor:
Antonio Brucato, Alistair Wheeler, Sushil A Luis, Antonio Abbate, Paul C Cremer, Fang Fang, Antonella Insalaco, Martin M Lewinter, Basil S Lewis, David Lin, Stephen J Nicholls, Jay B Chatfield, Allan L Klein, Massimo Imazio, John F Paolini
Publikováno v:
Circulation: Cardiovascular Quality and Outcomes. 15
Background: Post-episode tapering of Standard of Care (SoC) medication in patients with recurrent pericarditis (RP) varies considerably. Gradual tapering of corticosteroids (CS) is recommended in ESC guidelines (decreasing by 1-2.5 mg/day every 2-6 w