Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Martin M. Knight"'
Autor:
Stefaan W. Verbruggen, Joanne Nolan, Michael P. Duffy, Oliver M.T. Pearce, Christopher R. Jacobs, Martin M. Knight
Publikováno v:
Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)
Abstract Bone metastases are a common cause of suffering in breast and prostate cancer patients, however, the interaction between bone cells and cancer cells is poorly understood. Using a series of co‐culture, conditioned media, human cancer sphero
Externí odkaz:
https://doaj.org/article/76aa04d7a7fa4f45a303ab43a8ff8637
Autor:
Mary-Kate Hayward, Michael D. Allen, Jennifer J. Gomm, Iain Goulding, Clare L. Thompson, Martin M. Knight, John F. Marshall, J. Louise Jones
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Women with ductal carcinoma in situ (DCIS) have an increased risk of progression to invasive breast cancer. Although not all women with DCIS will progress to invasion, all are treated as such, emphasising the need to identify prognostic biom
Externí odkaz:
https://doaj.org/article/df3865fd8d414597839305295fcc1d88
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 1, Pp 15-26 (2020)
Externí odkaz:
https://doaj.org/article/cabccde3e194480ba4e5a1e80ecacf45
Autor:
Waqas Badar, Husna Ali, Olivia N. Brooker, Elis Newham, Tim Snow, Nicholas J. Terrill, Gianluca Tozzi, Peter Fratzl, Martin M. Knight, Himadri S. Gupta
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
The bone-cartilage unit (BCU) is a universal feature in diarthrodial joints, which is mechanically-graded and subjected to shear and compressive strains. Changes in the BCU have been linked to osteoarthritis (OA) progression. Here we report existence
Externí odkaz:
https://doaj.org/article/add426dc05554ea29f693210e835672a
Autor:
Robin M. Delaine-Smith, Eleni Maniati, Beatrice Malacrida, Sam Nichols, Reza Roozitalab, Roanne R. Jones, Laura S.M. Lecker, Oliver M.T. Pearce, Martin M. Knight, Frances R. Balkwill
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102674- (2021)
Summary: In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand
Externí odkaz:
https://doaj.org/article/6068ad32821044adbec1edf7e797e977
Autor:
Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M.T. Pearce
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102676- (2021)
Summary: Guided by a multi-level “deconstruction” of omental metastases, we developed a tetra (four cell)-culture model of primary human mesothelial cells, fibroblasts, adipocytes, and high-grade serous ovarian cancer (HGSOC) cell lines. This mul
Externí odkaz:
https://doaj.org/article/99a346004e8b4e63bd0a6643a5d15ba8
Autor:
Rebecca V. Walker, Jennifer L. Keynton, Daniel T. Grimes, Vrinda Sreekumar, Debbie J. Williams, Chris Esapa, Dongsheng Wu, Martin M. Knight, Dominic P. Norris
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The molecular role of ciliary Polycystin-2 (PC2) in cyst formation and polycystic kidney disease (ADKPD) is unclear. Here, the authors identify a PC2 mutant lacking ciliary localisation but with active Ca2+ channel function in mice, that is sufficien
Externí odkaz:
https://doaj.org/article/547e1a8754cb4905b8faf5dab5e28885
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/f6c7c46be7ef4ecfbd37a128ed3ce39f
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and disease hold great promise for improving fundamental research, drug
Externí odkaz:
https://doaj.org/article/0ec38aad05f64e0093bd6c4e9eb2081a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4313 (2021)
Primary cilia and associated intraflagellar transport are essential for skeletal development, joint homeostasis, and the response to mechanical stimuli, although the mechanisms remain unclear. Polycystin-2 (PC2) is a member of the transient receptor
Externí odkaz:
https://doaj.org/article/03efa0c4b34a42b3968fb5bafa18be76