Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Martin M Matzuk"'
Autor:
Yuki Oyama, Haruhiko Miyata, Keisuke Shimada, Yoshitaka Fujihara, Keizo Tokuhiro, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa
Publikováno v:
Asian Journal of Andrology, Vol 24, Iss 3, Pp 266-272 (2022)
Gene expression analyses suggest that more than 1000–2000 genes are expressed predominantly in mouse and human testes. Although functional analyses of hundreds of these genes have been performed, there are still many testis-enriched genes whose fun
Externí odkaz:
https://doaj.org/article/7f88ba8a95df47dfb5206782c6123575
Autor:
Kaori Nozawa, Zian Liao, Yuhkoh Satouh, Ting Geng, Masahito Ikawa, Diana Monsivais, Martin M Matzuk
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0289083 (2023)
Wee1-like protein kinase 2 (WEE2) is an oocyte-specific protein tyrosine kinase involved in the regulation of oocyte meiotic arrest in humans. As such, it has been proposed as a candidate for non-hormonal female contraception although pre-clinical mo
Externí odkaz:
https://doaj.org/article/9c7081c042f6466f8c4619d20bec97a6
Autor:
Seiya Oura, Samina Kazi, Audrey Savolainen, Kaori Nozawa, Julio Castañeda, Zhifeng Yu, Haruhiko Miyata, Ryan M Matzuk, Jan N Hansen, Dagmar Wachten, Martin M Matzuk, Renata Prunskaite-Hyyryläinen
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008954 (2020)
The flagellum is essential for sperm motility and fertilization in vivo. The axoneme is the main component of the flagella, extending through its entire length. An axoneme is comprised of two central microtubules surrounded by nine doublets, the nexi
Externí odkaz:
https://doaj.org/article/c65b11ab4c4a4126bee3f3b215d7ad15
Autor:
Martin R L Paine, Jaeyeon Kim, Rachel V Bennett, R Mitchell Parry, David A Gaul, May D Wang, Martin M Matzuk, Facundo M Fernández
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154837 (2016)
High-grade serous carcinoma (HGSC) is the most common and deadliest form of ovarian cancer. Yet it is largely asymptomatic in its initial stages. Studying the origin and early progression of this disease is thus critical in identifying markers for ea
Externí odkaz:
https://doaj.org/article/293e5bfe8f6e427fa34f378f7ae246b2
Autor:
Kalpana Kannan, Cristian Coarfa, Kimal Rajapakshe, Shannon M Hawkins, Martin M Matzuk, Aleksandar Milosavljevic, Laising Yen
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004216 (2014)
Ovarian cancer is the fifth leading cause of cancer death in women. Almost 70% of ovarian cancer deaths are due to the high-grade serous subtype, which is typically detected only after it has metastasized. Characterization of high-grade serous cancer
Externí odkaz:
https://doaj.org/article/957ab4ae8d464651a58cacfe92212c4d
Autor:
Caterina Clementi, Swamy K Tripurani, Michael J Large, Mark A Edson, Chad J Creighton, Shannon M Hawkins, Ertug Kovanci, Vesa Kaartinen, John P Lydon, Stephanie A Pangas, Francesco J DeMayo, Martin M Matzuk
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003863 (2013)
Implantation of a blastocyst in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in
Externí odkaz:
https://doaj.org/article/adc21490ea394fb780da440a56cbc1aa
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72689 (2013)
The spermatogonial stem cell (SSC) compartment is maintained by self-renewal of stem cells as well as fragmentation of differentiating spermatogonia through abscission of intercellular bridges in a random and stochastic manner. The molecular mechanis
Externí odkaz:
https://doaj.org/article/8982b7c590ff48ed84ee08c39a465bf7
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38914 (2012)
Stem cells have a potential of gene therapy for regenerative medicine. Among various stem cells, spermatogonial stem cells have a unique characteristic in which neighboring cells can be connected by intercellular bridges. However, the roles of interc
Externí odkaz:
https://doaj.org/article/983c3047b3874a1582f180d995e7b03f
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002320 (2011)
The transforming growth factor β (TGFβ) superfamily proteins are principle regulators of numerous biological functions. Although recent studies have gained tremendous insights into this growth factor family in female reproduction, the functions of
Externí odkaz:
https://doaj.org/article/e1ceb6010fe94cb2b9cb868864499847
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17066 (2011)
Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. We previously reported the identification of TEX14 as the first essential intercellular bridge protein, the demonstration that intercellular bridge
Externí odkaz:
https://doaj.org/article/254435e6dbbe4c1ba26782c8d645d545