Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Martin M, Bednar"'
Autor:
Eric McDade, Martin M. Bednar, H. Robert Brashear, David S. Miller, Paul Maruff, Christopher Randolph, Zahinoor Ismail, Maria C. Carrillo, Christopher J. Weber, Lisa J. Bain, Ann Marie Hake
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Alzheimer's disease (AD) is a continuum consisting of a preclinical stage that occurs decades before symptoms appear. As researchers make advances in investigating the continuum, the importance of developing drugs for secondary prevention is
Externí odkaz:
https://doaj.org/article/a1ef83d3bba8417fb95f0903fde9ba8b
Autor:
Polyna Khudyakov, Maria S. Quinton, Wei Yin, Saurabh Gupta, Deborah S. Hartman, Dimitrios Arkilo, Jie Lin, Laura Rosen, Jens R. Wendland, Jim Hazel, Martin M. Bednar
Publikováno v:
British Journal of Clinical Pharmacology. 87:4756-4768
Aims Dysregulation of histone methylation epigenetic marks may result in intellectual and developmental disability, as seen in Kabuki syndrome. Animal data suggest that increasing histone methylation by inhibiting lysine-specific demethylase 1A (LSD1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d95521bc2b88788b5b0a41298167ac
https://doi.org/10.1111/bcp.14912
https://doi.org/10.1111/bcp.14912
Autor:
David Miller, H. Robert Brashear, Christopher J. Weber, Christopher Randolph, Eric McDade, Paul Maruff, Lisa J. Bain, Martin M. Bednar, Zahinoor Ismail, Maria C. Carrillo, Ann Marie Hake
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's disease (AD) is a continuum consisting of a preclinical stage that occurs decades before symptoms appear. As researchers make advances in investigating the continuum, the importance of developing drugs for secondary prevention is garnerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4c84c3a8cd3e3a7a3882283d818300
http://europepmc.org/articles/PMC7453146
http://europepmc.org/articles/PMC7453146
Autor:
Jaren W. Landen, Niels Andreasen, Carol Cronenberger, Henrik Östlund, Martin M. Bednar, Anne Börjesson-Hanson, Pamela F. Schwartz, Catherine Sattler, Brendon Binneman
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction The safety, pharmacokinetics, and effect on peripheral and central amyloid β (Aβ) of multiple doses of ponezumab, an anti-Aβ monoclonal antibody, were characterized in subjects with mild-to-moderate Alzheimer's disease treated for 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05e9a2f46f21ad971447eaf9632b73e
http://europepmc.org/articles/PMC5651442
http://europepmc.org/articles/PMC5651442
Autor:
Sharon Cohen, Qinying Zhao, Carol Cronenberger, Aaron H. Burstein, Pamela F. Schwartz, William T. Duggan, Martin M. Bednar, Kejal Kantarci, Clifford R. Jack, Brendon Binneman, Scot Styren, Jae-Hong Lee, Jaren W. Landen, Clare B. Billing, Ken J. Sprenger, Catherine Sattler
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Multiple intravenous doses of ponezumab, an anti-amyloid antibody, were evaluated in subjects with mild-to-moderate Alzheimer's disease (AD). Methods In part A, 77 subjects were randomized to ponezumab 0.1, 0.5, or 1 mg/kg (75 treated) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5783ab75f707d14e03dc8c2932164ab
https://doi.org/10.1016/j.trci.2017.04.003
https://doi.org/10.1016/j.trci.2017.04.003
Autor:
Jessica Mancuso, N DeMartinis, Swapnil Gupta, Deepak Cyril D'Souza, Mohini Ranganathan, John D. Cahill, B Huguenel, F Gaudreault, Martin M. Bednar, Laura Zumpano, C L Shaffer, Mohamed Sherif
Publikováno v:
Molecular Psychiatry. 22:1633-1640
There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fa4cc5cbdd11b2c4d28e58823a8525
https://doi.org/10.1038/mp.2017.6
https://doi.org/10.1038/mp.2017.6
Autor:
Martin M, Bednar
Publikováno v:
Progress in molecular biology and translational science. 168
The failure to date of all disease modifying therapies for Alzheimer's disease and related dementias requires a serious rethinking of the field's approach to therapeutic interventions. This begins with the acknowledgement that the great majority of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bb7de7b1274ebbce65e01e3ab3b9229
https://pubmed.ncbi.nlm.nih.gov/31699322
https://pubmed.ncbi.nlm.nih.gov/31699322
Autor:
Martin M. Bednar
The failure to date of all disease modifying therapies for Alzheimer's disease and related dementias requires a serious rethinking of the field's approach to therapeutic interventions. This begins with the acknowledgement that the great majority of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ca6d318d5b477976aa9ce3bdd48744a
https://doi.org/10.1016/bs.pmbts.2019.10.001
https://doi.org/10.1016/bs.pmbts.2019.10.001
Autor:
Martin M. Bednar, Claire Leurent, James A. Goodman, Steven M. Greenberg, Monica Lindsay, Eric E. Smith, Yao Zhang, Ping He, Usharbudh Shivraj Sohur, Mahmut Edip Gurol, Anand Viswanathan, Jonathan R. Polimeni, Linda Frattura
Publikováno v:
Annals of Clinical and Translational Neurology, 6, 795-806
Annals of Clinical and Translational Neurology, 6, 4, pp. 795-806
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, 6, 4, pp. 795-806
Annals of Clinical and Translational Neurology
Contains fulltext : 207168.pdf (Publisher’s version ) (Open Access) Objective: Cerebral amyloid angiopathy (CAA) is caused by cerebrovascular deposition of beta-amyloid fragments leading to cerebrovascular dysfunction and other brain injuries. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6dfcb4685279750ab544fa32f67e61
http://hdl.handle.net/2066/207168
http://hdl.handle.net/2066/207168
Autor:
Franco, Di Cesare, Jessica, Mancuso, Phil, Woodward, Martin M, Bednar, Peter T, Loudon, Jin-Moo, Harris
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 25:642-649
Background The therapeutic potential of phosphodiesterase-5 inhibitor PF-03049423 was evaluated in a phase 2, multicenter, randomized, double-blind, placebo-controlled study of subjects with acute ischemic stroke (Clinical Trial Registration Informat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3533389c96991e62586954608448bb0d
https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.026
https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.026