Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Martin Lochner"'
Autor:
Daniel Bátora, Ágnes Dienes-Nagy, Liming Zeng, Christian E. Gerber, Jérôme P. Fischer, Martin Lochner, Jürg Gertsch
Publikováno v:
Food Chemistry: X, Vol 23, Iss , Pp 101592- (2024)
Tannins are chemically diverse polyphenols in plant-derived products that not only show diverse biological activities but also play a crucial role in determining the sensory attributes of food and beverages. Therefore, their accurate and cost-effecti
Externí odkaz:
https://doaj.org/article/d5fcab5656db494b9c7ac8e066ac4186
Autor:
Sven Kappel, Korollus Melek, Daniela Ross-Kaschitza, Barbara Hauert, Christian E. Gerber, Martin Lochner, Christine Peinelt
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Upon activation at low pH, TMEM206 conducts Cl− ions across plasma and vesicular membranes. In a (patho)physiological context, TMEM206 was reported to contribute to acid-induced cell death in neurons, kidney and cervical epithelial ce
Externí odkaz:
https://doaj.org/article/503c6247f68848779b4f4a3c5e221059
Autor:
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re
Externí odkaz:
https://doaj.org/article/248fd0638f5942beb0219612bf9fe670
Autor:
Barbara Preti, Jean-Sébastien Rougier, Irida Papapostolou, Florian Bochen, Christian E. Gerber, Hugues Abriel, Martin Lochner, Christine Peinelt
Publikováno v:
CHIMIA, Vol 76, Iss 12 (2022)
The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecu
Externí odkaz:
https://doaj.org/article/344d922443754d068dbe864dca6661ba
Autor:
Prakash Arullampalam, Barbara Preti, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sébastien Rougier, Hugues Abriel
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: The Transient Receptor Potential Melastatin member 4 (TRPM4) gene encodes a calcium-activated non-selective cation channel expressed in several tissues. Mutations in TRPM4 have been reported in patients with different types of cardiac con
Externí odkaz:
https://doaj.org/article/21cf137dbdef48c6a253499e00e162a1
Autor:
Achille Schild, Rajesh Bhardwaj, Nicolas Wenger, Dominic Tscherrig, Palanivel Kandasamy, Jan Dernič, Roland Baur, Christine Peinelt, Matthias A. Hediger, Martin Lochner
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5604 (2020)
Calcium ions regulate a wide array of physiological functions including cell differentiation, proliferation, muscle contraction, neurotransmission, and fertilization. The endoplasmic reticulum (ER) is the major intracellular Ca2+ store and cellular e
Externí odkaz:
https://doaj.org/article/5e40f6c15bbf4406b19eff638db0b261
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2458 (2020)
Store-operated heteromeric Orai1/Orai3 channels have been discussed in the context of aging, cancer, and immune cell differentiation. In contrast to homomeric Orai1 channels, they exhibit a different pharmacology upon application of reactive oxygen s
Externí odkaz:
https://doaj.org/article/bc282235f2e34f0785d6caec27a8d1fb
Publikováno v:
CHIMIA, Vol 68, Iss 4 (2014)
The 5-HT3 receptor is one of several ion channels responsible for the transmission of nerve impulses in the peripheral and central nervous systems. Until now, it has been difficult to characterize transmembrane receptors with classical structural bio
Externí odkaz:
https://doaj.org/article/262537a0607946c9aa1e2ddde2c91ed9
Autor:
Martin Lochner
Publikováno v:
CHIMIA, Vol 64, Iss 4 (2010)
Ion channels are transmembrane protein complexes that are found in virtually all cells. They fulfill a crucial physiological function by facilitating communication between and within cells. Consequently, impaired channel function, e.g. due to mutatio
Externí odkaz:
https://doaj.org/article/4d5ab6a7e10f4be7b858bd75f93640f8
Autor:
Martin Lochner
Publikováno v:
CHIMIA, Vol 58, Iss 6 (2004)
Externí odkaz:
https://doaj.org/article/f13d6de267824f3d97855ebff8e50176