Výsledky vyhledávání - "Martin Letzkus"

Akademický článek

Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials

Autor: Martin Letzkus, Evert Luesink, Sandrine Starck‐Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson, Frank Staedtler

Publikováno v: Clinical and Translational Medicine, Vol 3, Iss 1, Pp n/a-n/a (2014)

Abstract Background Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases influence the freque

Externí odkaz: https://doaj.org/article/a89ba6399fa14393a9f39439963303b9

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Akademický článek

Perturbation of microRNAs in rat heart during chronic doxorubicin treatment.

Autor: Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40395 (2012)

Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff

Externí odkaz: https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0

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Akademický článek

Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples.

Autor: Ting Gong, Nicole Hartmann, Isaac S Kohane, Volker Brinkmann, Frank Staedtler, Martin Letzkus, Sandrine Bongiovanni, Joseph D Szustakowski

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27156 (2011)

Large-scale molecular profiling technologies have assisted the identification of disease biomarkers and facilitated the basic understanding of cellular processes. However, samples collected from human subjects in clinical trials possess a level of co

Externí odkaz: https://doaj.org/article/da815292e99e455aa67f4a3c9eaaaff0

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Akademický článek

Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment.

Autor: Ramin Radpour, Zeinab Barekati, Corina Kohler, Martin M Schumacher, Thomas Grussenmeyer, Paul Jenoe, Nicole Hartmann, Suzette Moes, Martin Letzkus, Johannes Bitzer, Ivan Lefkovits, Frank Staedtler, Xiao Yan Zhong

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27355 (2011)

BACKGROUND: The contribution of aberrant DNA methylation in silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza

Externí odkaz: https://doaj.org/article/8131c0f3b5f44e2f97abbbc442451221

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IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis

Publikováno v: Journal of Allergy and Clinical Immunology. 144:750-763

Background Hyperactivity of the IL-23/IL-17 axis is central to plaque psoriasis pathogenesis. Secukinumab, a fully human mAb that selectively inhibits IL-17A, is approved for treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b90526d4e73be54560617fc2aa646c3
https://doi.org/10.1016/j.jaci.2019.04.029

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Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: A randomized, double‐blind, placebo‐controlled study

Autor: Martin Letzkus, Michael T. Beste, Martin Metz, Veit J. Erpenbeck, Petra Staubach, Janine Gericke, Nicole Hartmann, Andrea Bauer, Randolf Brehler, Sergio Kaiser, Marcus Maurer, Rebecca I. Torene

Publikováno v: Allergy. 74:141-151

Introduction and objectives. Chronic spontaneous urticaria (CSU), including severe and treatment-refractory CSU, shows a strong response to omalizumab, a humanized recombinant monoclonal anti-IgE antibody. The effect of omalizumab on gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71528eef4d5fd793a43b1ab22a932ab7
https://doi.org/10.1111/all.13547

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The effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients

Autor: Diego Albrecht, Thomas Jax, Rudi Stinkens, Nicolaas C. Schaper, Ellen E. Blaak, Jens Jordan, Bas Havekes, Johan W. E. Jocken, Marcus May, Christoph Schindler, B. W. van der Kolk, Martin Letzkus, Nicole Hartmann, Thomas Langenickel, T. Heise, Gijs H. Goossens, Sergio Kaiser, Stefan Engeli

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports, 8:3933. Nature Publishing Group

Increased activation of the renin-angiotensin system is involved in the onset and progression of cardiometabolic diseases, while natriuretic peptides (NP) may exert protective effects. We have recently demonstrated that sacubitril/valsartan (LCZ696),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948e05840550d0d7735bdbc4ecc3f2c8
http://europepmc.org/articles/PMC5834447

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Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome

Autor: Roberta Caorsi, Rebecca I. Torene, Sandrine Starck-Schwertz, Marco Cattalini, Laura Obici, Marco Gattorno, N. R. Nirmala, V. Tormey, Helen J. Lachmann, Ken Abrams, Martin Letzkus, Nicole Hartmann

Publikováno v: Annals of the Rheumatic Diseases

ObjectiveTo explore whether gene expression profiling can identify a molecular mechanism for the clinical benefit of canakinumab treatment in patents with tumour necrosis factor receptor-associated periodic syndrome (TRAPS).MethodsBlood samples were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab722bb88f55794f9695f2f33aa3c0c8
http://hdl.handle.net/10379/14182

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Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis

Autor: Martin Letzkus, Jens-Michael Jensen, Ehrhardt Proksch, Jeanne Kehren, Regina Fölster-Holst, Sandrine Bongiovanni, Thomas Schwarz, Andreas Scherer, Michael Weichenthal, Matthias Bräutigam, M. Zuehlsdorf, Frank Staedtler, Christine Wanke

Publikováno v: Allergy. 67:413-423

To cite this article: Jensen JM, Scherer A, Wanke C, Brautigam M, Bongiovanni S, Letzkus M, Staedtler F, Kehren J, Zuehlsdorf M, Schwarz T, Weichenthal M, Folster-Holst R, Proksch E. Gene expression is differently affected by pimecrolimus and betamet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c06fa293c55657db41c06126da0a9ae
https://doi.org/10.1111/j.1398-9995.2011.02747.x

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