Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martin Lepší"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Accurate estimation of protein–ligand binding affinity is the cornerstone of computer-aided drug design. We present a universal physics-based scoring function, named SQM2.20, addressing key terms of binding free energy using semiempirical
Externí odkaz:
https://doaj.org/article/517c9f3900db4a11a34a83b1a51e58d9
Autor:
Marcela Pávová, Paul Eduardo Reyes-Gutiérrez, Jaroslav Kozák, Juraj Dobiaš, Yevgen Yurenko, Martin Lepšík, Filip Teplý, Jan Weber
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The secondary structure of nucleic acids containing quartets of guanines, termed G-quadruplexes, is known to regulate the transcription of many genes. Several G-quadruplexes can be formed in the HIV-1 long terminal repeat promoter region and
Externí odkaz:
https://doaj.org/article/dc4ed802e78c41dc9e285b6807d85f86
Autor:
Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 515-526 (2022)
Cathepsin K (CatK) is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is unknown. We in
Externí odkaz:
https://doaj.org/article/c51df7b09c7a427fa4eefb8b01b73746
Autor:
Jiří Dostál, Jiří Brynda, Lucie Vaňková, Syeda Rehana Zia, Iva Pichová, Olga Heidingsfeld, Martin Lepšík
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 914-921 (2021)
Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C. parapsilosis (Sapp1p) is
Externí odkaz:
https://doaj.org/article/1cbee76a9c124aa0ab6b2f3f0de9c5a3
Autor:
Jakub Gemperle, Rozálie Hexnerová, Martin Lepšík, Petr Tesina, Michal Dibus, Marian Novotný, Jan Brábek, Václav Veverka, Daniel Rosel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract CAS is a docking protein downstream of the proto-oncogene Src with a role in invasion and metastasis of cancer cells. The CAS SH3 domain is indispensable for CAS-mediated signaling, but structural aspects of CAS SH3 ligand binding and regula
Externí odkaz:
https://doaj.org/article/9f3efa9a9d654d38ab0c7c109782bb44
Autor:
Haresh Ajani, Adam Pecina, Saltuk M. Eyrilmez, Jindřich Fanfrlík, Susanta Haldar, Jan Řezáč, Pavel Hobza, Martin Lepšík
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 4022-4029 (2017)
Externí odkaz:
https://doaj.org/article/7a99820a4bb542748f3b81fb8c367007
Autor:
Iva Machová, Martin Hubálek, Martin Lepšík, Lucie Bednárová, Markéta Pazderková, Vladimír Kopecký, Jan Snášel, Jiří Dostál, Iva Pichová
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170373 (2017)
Mycobacterium tuberculosis (MTb), the causative agent of tuberculosis, can persist in macrophages for decades, maintaining its basic metabolic activities. Phosphoenolpyruvate carboxykinase (Pck; EC 4.1.1.32) is a key player in central carbon metaboli
Externí odkaz:
https://doaj.org/article/8b39c3a24d804c8aa7cdc914dd6e067a
Publikováno v:
Phytotaxa. 594:43-52
A new nemophilous tetraploid bramble species, Rubus lentianus of the series Radula, occurring in Central Europe (Upper Austria and Lower Bavaria), is described. Deeply incised terminal leaflets of primocane leaves and a long, abruptly narrowing apex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e2aa55adad6ce0754b6408ec085518f
https://doi.org/10.11646/phytotaxa.594.1.2
https://doi.org/10.11646/phytotaxa.594.1.2
Publikováno v:
Curtis's Botanical Magazine. 39:705-715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c47791ce3339c2cfac8d59da3856b6
https://doi.org/10.1111/curt.12480
https://doi.org/10.1111/curt.12480
Publikováno v:
Folia Geobotanica. 57:213-228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bc434ec020b9e655fa331bc82af5d4a
https://doi.org/10.1007/s12224-022-09420-3
https://doi.org/10.1007/s12224-022-09420-3