Výsledky vyhledávání - "Martin Lensch"

Toward Comprehensive Analysis of the Galectin Network in Chicken: Unique Diversity of Galectin-3 and Comparison of its Localization Profile in Organs of Adult Animals to the Other Four Members of this Lectin Family

Autor: Wolf D. Lehmann, Dolores Solís, Sabine André, Joachim C. Manning, Michaela Lohr, Martin Lensch, Joerg Seidler, Hans-Joachim Gabius, Dieter Kübler, Lara López-Merino, Herbert Kaltner

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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18 pags, 11 figs, 2 tabs. -- Additional Supporting Information may be found in the online version of this article
Characterization of all members of a gene family established by gene divergence is essential to delineate distinct or overlapping e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c3fcba613648dbc00aa32db1e9c4a5
https://doi.org/10.1002/ar.21341

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Analysis of MonoPEGylated Human Galectin-2 by Small-Angle X-ray and Neutron Scattering: Concentration Dependence of PEG Conformation in the Conjugate

Autor: Martin Lensch, Vasil M Garamus, Conan J. Fee, Tracey Hanley, Hans-Joachim Gabius, Lizhong He, Anton P. J. Middelberg, Hui Wang

Publikováno v: Biomacromolecules. 11:3504-3510

Protein conjugation with polyethylene glycol (PEG) is a valuable means for improving stability, solubility, and bioavailability of pharmaceutical proteins. Using human galectin-2 (hGal-2) and 5 kDa PEG as a model system we first produced a PEG-hGal-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985b78377c01442909cad8fd4a0233ad
https://doi.org/10.1021/bm100999a

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Carbamate-Linked Lactose: Design of Clusters and Evidence for Selectivity to Block Binding of Human Lectins to (Neo)Glycoproteins with Increasing Degree of Branching and to Tumor Cells

Autor: Valentin Wittmann, Nicolai V. Bovin, Martin Lensch, Daniel Specker, Herbert Kaltner, Sabine André, Hans-Joachim Gabius

Publikováno v: Bioconjugate Chemistry. 20:1716-1728

Various pathogenic processes are driven by protein(lectin)-glycan interactions, especially involving beta-galactosides at branch ends of cellular glycans. These emerging insights fuel the interest to design potent inhibitors to block lectins. As a st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60f4206546f313fa4ca7eaefe6cd237
https://doi.org/10.1021/bc900152w

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Single-Site Cys-Substituting Mutation of Human Lectin Galectin-2: Modulating Solubility in Recombinant Production, Reducing Long-Term Aggregation, and Enabling Site-Specific MonoPEGylation

Autor: Anton P. J. Middelberg, Lizhong He, Hans-Joachim Gabius, Martin Lensch, Conan J. Fee, Hui Wang

Publikováno v: Biomacromolecules. 9:3223-3230

The effector capacity of endogenous lectins on cell adhesion/growth prompts studies to turn them into pharmaceutically stable forms. Using human galectin-2 as a proof-of-principle model, we first introduced mutations at the site of one of the two Cys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2f92e8c5985d14666e868649dc35e6
https://doi.org/10.1021/bm800801b

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Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresia/luteolysis in contrast to pro-apoptotic galectins-1 and -7

Autor: Sabine André, Fred Sinowatz, Herbert Kaltner, Martin Lensch, Hans-Joachim Gabius, Michaela Lohr

Publikováno v: Histochemistry and Cell Biology. 130:567-581

Galectin-3 is a multifunctional protein with modular design. A distinct expression profile was determined in various murine organs when set into relation to homodimeric galectins-1 and -7. Fittingly, the signature of putative transcription-factor-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10591fcfff82dae381f1c8b0427ec392
https://doi.org/10.1007/s00418-008-0465-0

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Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes

Autor: Herbert Kaltner, Martin Herrmann, Peter Kern, Alexandra Beer, Connie Schulze, Hans-Joachim Gabius, Kerstin Sarter, Sabine André, Udo S. Gaipl, Martin Lensch, Sandra Franz

Publikováno v: Cytometry Part A. :139-147

Changes in the glycomic profile can significantly affect the cells' communication with the environment. Plant lectins have so far been used to address the issue as to whether the courses of apoptosis or necrosis are associated with such alterations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9326da3f4afc10e840a525082f89ab17
https://doi.org/10.1002/cyto.a.20510

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Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

Autor: Michaela Lohr, Martina Schnölzer, Jürgen Kopitz, Herbert Kaltner, Martin Lensch, José L. Saiz, Michael Mürnseer, Joachim C. Manning, Sabine André, Hans-Joachim Gabius, Dolores Solís

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Prototype galectins are versatile modulators of cell adhesion and growth via their reactivity to certain carbohydrate and protein ligands. These functions and the galectins' marked developmental regulation explain their attractiveness as models to di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecea73d6013de74088fcc26c2b194bfe
https://doi.org/10.1042/bj20070419

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Gene-expression signature of adhesion/growth-regulatory tissue lectins (galectins) in transitional cell cancer and its prognostic relevance

Autor: Hans-Joachim Gabius, P. Alken, M. Hatzinger, Specht K, Martin Lensch, Sigrun Langbein, Sabine André, Jasmin Katrin Badawi, Herbert Kaltner, Brinck U, Brade J

Publikováno v: Histopathology, 51(5), 681-690. Wiley-Blackwell

Aims: Lectins, and especially galectins, appear to be important in malignancy-associated processes. The aim was to analyse comprehensively the presence of galectins in urothelial tumours. Methods and results: Non-cross-reactive antibodies against sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632b4be92b9395b25ada9542355a1e89
https://doi.org/10.1111/j.1365-2559.2007.02852.x

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Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation

Autor: Albert M. Wu, Tanuja Singh, Sabine André, Hans-Joachim Gabius, Martin Lensch, June H. Wu

Publikováno v: Glycobiology. 16:524-537

Cell-surface glycans are functional docking sites for tissue lectins such as the members of the galectin family. This interaction triggers a wide variety of responses; hence, there is a keen interest in defining its structural features. Toward this a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc33409508150a6a300ede0b611eac81
https://doi.org/10.1093/glycob/cwj102

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Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence

Autor: Hans-Joachim Gabius, Martin Lensch, Michaela Lohr, Sabine André, Roland Russwurm, Herbert Kaltner, Michel Vidal

Publikováno v: The International Journal of Biochemistry & Cell Biology. 38:1741-1758

Presence of species-specific gene divergence in a protein family prompts to thoroughly study structural aspects and expression profiles of the products. We herein focus on two members of an adhesion/growth-regulatory group of endogenous lectins, i.e.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f694d11a0c6e03007d716ccc20b8d0
https://doi.org/10.1016/j.biocel.2006.04.004

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