Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Martin Leníček"'
Autor:
Stanislav Sevela, Eva Meisnerova, Marek Vecka, Lucie Vavrova, Jana Rychlikova, Martin Lenicek, Libor Vitek, Olga Novakova, Frantisek Novak
Publikováno v:
Nutrients, Vol 16, Iss 4, p 485 (2024)
(1) Objectives: Intestinal failure in home parenteral nutrition patients (HPNPs) results in oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to various lipid emulsions influences antioxidant status and
Externí odkaz:
https://doaj.org/article/da1465ea2ef945d58652a1f474e45cae
Autor:
Václav Šmíd, Karel Dvořák, Petr Šedivý, Vít Kosek, Martin Leníček, Monika Dezortová, Jana Hajšlová, Milan Hájek, Libor Vítek, Kamila Bechyňská, Radan Brůha
Publikováno v:
Hepatology Communications, Vol 6, Iss 6, Pp 1336-1349 (2022)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. n‐3 polyunsaturated fatty acids (n‐3‐PUFAs) have been reported to ameliorate the progression of NAFLD in experimental studies; however, clinical trials have yiel
Externí odkaz:
https://doaj.org/article/ac9851f6a8084a2786db1dc1a9a79346
Autor:
Martin Leníček, Václav Šmíd, Petr Pajer, Anna Nazarova, Karel Dvořák, Iva Subhanová, Radan Brůha, Libor Vítek
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract The patatin-like phospholipase domain containing 3 (PNPLA3) gene (viz. its I148M variant) is one of the key players in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We have identified a novel insertion/deletion variant of 111
Externí odkaz:
https://doaj.org/article/5581a4fd50f34deaa352f9233e04797f
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236372 (2020)
Enzymatic assays based on bacterial 3α-hydroxysteroid dehydrogenase are the method of choice for quantification of total bile acids (BAs) in serum. Although non-specific, it is generally considered precise and robust. The aim of this study was to in
Externí odkaz:
https://doaj.org/article/be6666e36c6641dcb4649fb975e15027
Autor:
Ümran Ay, Martin Leníček, Arno Classen, Steven W. M. Olde Damink, Carsten Bolm, Frank G. Schaap
Publikováno v:
Metabolites, Vol 12, Iss 2, p 176 (2022)
Biotransformation of host bile salts by gut microbes results in generation of secondary bile salt species that have biological and physicochemical properties that are distinct from the parent compounds. There is increased awareness that a bile salt
Externí odkaz:
https://doaj.org/article/7e259f4ec9044c8f9408ad6c54fcac88
Autor:
Jaromír Petrtýl, Karel Dvořák, Jan Stříteský, Martin Leníček, Alena Jirásková, Václav Šmíd, Martin Haluzík, Radan Brůha, Libor Vítek
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 2000 (2021)
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide. The aim of our study was to assess the role of bilirubin, and the heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter
Externí odkaz:
https://doaj.org/article/033bb2e8916540f4bfa7ade8cf3b9de0
Autor:
Petr Urbánek, Martin Leníček, Lucie Muchová, Iva Subhanová, Ladislav Dušek, Nikola Kaspříkova, Petr Hrabal, Radan Brůha, Libor Vítek
Publikováno v:
Annals of Hepatology, Vol 10, Iss 4, Pp 445-451 (2011)
Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense.Objective. To assess the effect of promotervariations of HMOX1
Externí odkaz:
https://doaj.org/article/59f7a99e9d904c218f305fb439efa650
Autor:
Martin Leníček, Viktor Komárek, Miluše Zimolová, Jan Kovář, Milan Jirsa, Milan Lukáš, Libor Vítek
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 12, Pp 2664-2667 (2008)
Cholesterol 7α-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evalu
Externí odkaz:
https://doaj.org/article/5381afe81b2f4f9380bf5faab610369a
Autor:
Kateřina Žížalová, Barbora Nováková, Marek Vecka, Jaromír Petrtýl, Věra Lánská, Květa Pelinková, Václav Šmíd, Radan Brůha, Libor Vítek, Martin Leníček
Publikováno v:
Liver International. 43:888-895
Severity of portal hypertension is usually quantified by measuring the hepatic venous pressure gradient (HVPG). However, due to its invasiveness, alternative markers are being sought. Bile acids (BA), being synthesized, metabolized, and transported b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27355f6964dc37536ff2f3a0d8c4808e
https://doi.org/10.1111/liv.15481
https://doi.org/10.1111/liv.15481
Autor:
Berivan Gurbuz, Nurdan Guldiken, Philipp Reuken, Lei Fu, Katharina Remih, Christian Preisinger, Radan Brůha, Martin Leníček, Jaromír Petrtýl, Johanna Reissing, Mahmoud Aly, Malin Fromme, Biaohuan Zhou, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Andreas Stallmach, Tony Bruns, Pavel Strnad
Publikováno v:
Hepatology international 17(3), 698-708 (2023). doi:10.1007/s12072-022-10473-x
Hepatology international 17(3), 698-708 (2023). doi:10.1007/s12072-022-10473-x
Published by Springer, Heidelberg
Published by Springer, Heidelberg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fe41aca814219d5d452f4d999a6550
