Zobrazeno 1 - 10
of 709
pro vyhledávání: '"Martin L. Yarmush"'
Autor:
Ziya Isiksacan, Nishaka William, Rahime Senturk, Luke Boudreau, Celine Wooning, Emily Castellanos, Salih Isiksacan, Martin L. Yarmush, Jason P. Acker, O. Berk Usta
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Red blood cell (RBC) transfusions facilitate many life-saving acute and chronic interventions. Transfusions are enabled through the gold-standard hypothermic storage of RBCs. Today, the demand for RBC units is unfulfilled, partially due to t
Externí odkaz:
https://doaj.org/article/be755210cf55478ca1f637dfa842c2ea
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Supercooled preservation (SCP) is a technology that involves cooling a substance below its freezing point without initiating ice crystal formation. It is a promising alternative to prolong the preservation time of cells, tissues, engineered tissue pr
Externí odkaz:
https://doaj.org/article/e344a2b713ed478eab6b10a1b1a2299e
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Chimeric Antigen Receptor (CAR) T-cell therapy is a highly effective treatment for B-cell malignancies but limited in use due to clinically significant hyperinflammatory toxicities. Understanding the pathophysiologic mechanisms which mediate
Externí odkaz:
https://doaj.org/article/8090a777854644f98529a5ffd4e57303
Autor:
Ileana Marrero - Berrios, S. Elina Salter, Rishabh Hirday, Charles P. Rabolli, Andrea Tan, Clark T. Hung, Rene S. Schloss, Martin L. Yarmush
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 1, Pp 100432- (2024)
Objective: Osteoarthritis (OA) is a chronic joint disease, with limited treatment options, characterized by inflammation and matrix degradation, and resulting in severe pain or disability. Progressive inflammatory interaction among key cell types, in
Externí odkaz:
https://doaj.org/article/224e4a215c244cfa83e88bb1f229144f
Autor:
A. Aslihan Gokaltun, Letao Fan, Luca Mazzaferro, Delaney Byrne, Martin L. Yarmush, Tianhong Dai, Ayse Asatekin, O. Berk Usta
Publikováno v:
Bioactive Materials, Vol 25, Iss , Pp 415-429 (2023)
Despite decades of efforts, state-of-the-art synthetic burn dressings to treat partial-thickness burns are still far from ideal. Current dressings adhere to the wound and necessitate debridement. This work describes the first “supramolecular hybrid
Externí odkaz:
https://doaj.org/article/a35a2967a1464c16ba1ea17553284c02
Autor:
Letao Fan, Aslihan Gokaltun, Sarah Maggipinto, Yoshinori Kitagawa, Jeevendra Martyn, Heidi Yeh, Basak E. Uygun, Martin L. Yarmush, O. Berk Usta
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 243-261 (2023)
Background & Aims: Alterations in mitochondrial morphology and function and increased oxidative stresses in hepatocytes are well established in nonalcoholic fatty liver disease (NAFLD). Patients can undergo lifestyle changes, especially in earlier NA
Externí odkaz:
https://doaj.org/article/eb0b08a16174407d815dc363b82b8e1b
Autor:
Nishaka William, Ziya Isiksacan, Olga Mykhailova, Carly Olafson, Martin L. Yarmush, O. Berk Usta, Jason P. Acker
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Adenosine triphosphate (ATP) levels guide many aspects of the red blood cell (RBC) hypothermic storage lesions. As a result, efforts to improve the quality of hypothermic-stored red cell concentrates (RCCs) have largely centered around de
Externí odkaz:
https://doaj.org/article/4519cfa76d9e4d64ba0519eac92f672b
Autor:
Shannon N. Tessier, Reinier J. de Vries, Casie A. Pendexter, Stephanie E. J. Cronin, Sinan Ozer, Ehab O. A. Hafiz, Siavash Raigani, Joao Paulo Oliveira-Costa, Benjamin T. Wilks, Manuela Lopera Higuita, Thomas M. van Gulik, Osman Berk Usta, Shannon L. Stott, Heidi Yeh, Martin L. Yarmush, Korkut Uygun, Mehmet Toner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The limited preservation duration of donor organs is a big problem. Here the authors report a method for the freezing of whole rat livers at temperatures between −10 °C to −15 °C for up to 5 days, based on freeze-tolerant wood frogs, and term t
Externí odkaz:
https://doaj.org/article/033d5d8cc0c846d7b139393dd1af1722
Publikováno v:
Bioengineering, Vol 9, Iss 5, p 219 (2022)
End-stage liver diseases lead to mortality of millions of patients, as the only treatment available is liver transplantation and donor scarcity means that patients have to wait long periods before receiving a new liver. In order to minimize donor org
Externí odkaz:
https://doaj.org/article/fe331c6a295940848e31de5669d108e4
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Supercooled water is susceptible to spontaneous freezing, and preventing this process is a challenge. Here, the authors use surface sealing with immiscible liquids to eliminate primary ice nucleation at the water/air interface, enabling deep supercoo
Externí odkaz:
https://doaj.org/article/1795edf96b9b4b04a506a1de7df517ee